A5030241361- Dermatology and Skin Diseases
- Mycobacterium research and diagnosis
- IL-33, ST2, and ILC Pathways
- Ferroptosis and cancer prognosis
- Pharmacological Effects of Natural Compounds
- Inflammatory Bowel Disease
- Asthma and respiratory diseases
- Cancer Immunotherapy and Biomarkers
- Galectins and Cancer Biology
Beijing University of Chinese Medicine
2021-2024
Chronic inflammation can promote cancer development as observed in inflammation‐induced colorectal (CRC). However, the poor treatment outcomes emphasize need for effective treatment. Astragalus polysaccharide (APS), a vital component of natural drug Astragalus, has anti-tumor effects by inhibiting cell proliferation and enhancing immune function. In this study, we found that APS effectively suppressed CRC through activating CD8+ T cells reversing its inhibitory state tumor microenvironment...
Background: Hudi enteric-coated capsule (HDC) is a Chinese medicine prescribed to treat ulcerative colitis (UC).However, its anti-inflammatory active ingredients and mechanisms remain unknown.This study aimed investigate the components of HDC explore potential against UC by integrating network pharmacology experimental verification.Methods: A DSS-induced murine model was established validate efficacy detecting disease activity index (DAI) histopathological changes.Network pharmacological...
Abstract With the concept of gut–lung axis reinforced in recent years, emerging evidence has shown that intestinal homeostasis is vital for lung health. Nevertheless, impacts on tracts and their mechanism are rarely studied. Our results showed papain-induced asthmatic mice exhibited apparent colonic injuries compared with controls, including increased permeability, neutrophil Th17 infiltration lamina propria. Moreover, intranasal administration papain aggravated such dextran sulfate...