A5084226514- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
- Phytochemistry and biological activity of medicinal plants
- Extracellular vesicles in disease
- Gut microbiota and health
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
- Diet, Metabolism, and Disease
- Phagocytosis and Immune Regulation
- Pharmacological Effects of Natural Compounds
- Therapeutic Uses of Natural Elements
- Acupuncture Treatment Research Studies
- Ginseng Biological Effects and Applications
- Abdominal Surgery and Complications
- Pomegranate: compositions and health benefits
- MicroRNA in disease regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neonatal Health and Biochemistry
- Hydrogen's biological and therapeutic effects
- Gastrointestinal motility and disorders
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Chromatography in Natural Products
Sichuan University
2015-2024
West China Hospital of Sichuan University
2015-2024
Integrated Chinese Medicine (China)
2017-2023
Chinese Preventive Medicine Association
2019
Chengdu University of Traditional Chinese Medicine
2017
Fairmount Technologies (United States)
2015
To clarify the roles of organ failure and infection in outcome necrotizing pancreatitis.Results previous cohort studies that focused on acute pancreatitis are controversial.In this study, we collected medical records 447 patients with from January 2009 to June 2012. Data associated were analyzed.The overall mortality rate was 13% (58/447). Intervention performed 223 patients. Among these patients, 134 confirmed be infected necrosis by a positive culture. The 15% (13/89) sterile group 18%...
Severe acute pancreatitis-associated lung injury (SAP-ALI) is a serious disease associated with high mortality. Emodin has been applied to alleviate SAP-ALI; however, the mechanism remains unclear. We report that therapeutic role of emodin in attenuating SAP-ALI partly dependent on an exosomal mechanism. SAP rats had increased levels plasma exosomes altered protein contents compared sham rats. These infused tended accumulate lungs and promoted hyper-activation alveolar macrophages...
Integrins expressed on extracellular vesicles (EVs) secreted by various cancers are reported to mediate the organotropism of these EVs. Our previous experiment found that pancreatic tissue mice with severe cases acute pancreatitis (SAP) overexpresses several integrins and serum EVs (SAP-EVs) can lung injury (ALI). It is unclear if SAP-EV express promote their accumulation in ALI. Here, we report overexpress preincubation integrin antagonist peptide HYD-1 markedly attenuates pulmonary...
This article aims to elucidate the classification of and optimal treatment for pancreatic pseudocysts. Various approaches, including endoscopic drainage, percutaneous open surgery, have been employed management However, no scientific pseudocysts has devised, which could assist in selection therapy. We evaluated modalities used 893 patients diagnosed with according revision Atlanta our department between 2001 2010. All course disease >4 weeks mature cysts wall detected by computed tomography...
Severe acute pancreatitis (SAP), characterized by pancreatic acinar cell death, currently lacks effective targeted therapies. Ellagic acid (EA), rich in pomegranate, shows promising anti-inflammatory and antioxidant effects SAP treatment. However, the roles of other forms EA, such as plant extracellular vesicles (EVs) extracted from Urolithin A (UA), converted EA through gut microbiota metabolism vivo, have not been definitively elucidated. Our research aimed to compare pomegranate-derived...
Objectives To evaluate the safety and efficacy of early oral refeeding (EORF) in patients with mild acute pancreatitis (AP) to investigate optimal duration commence EORF. Methods A prospective, randomized, controlled trial was conducted AP. Patients EORF (started feeding once they subjectively felt hungry) were compared receiving routine (RORF) for time interval between disease onset initiation refeeding, total length hospitalization (LOH), postrefeeding LOH, adverse gastrointestinal events....
Objective: To investigate the protective effect of emodin in acute pancreatitis (AP)-associated lung injury and underlying mechanisms. Methods: NaT-AP model rats was constructed using 3.5% sodium taurocholate, CER+LPS-AP mice caerulein combined with Lipopolysaccharide. Animals were divided randomly into four groups: sham, AP, Ac-YVAD-CMK (caspase-1 specific inhibitor, AYC), groups. AP-associated assessed H&E staining, inflammatory cytokine levels, myeloperoxidase activity. Alveolar...
Abstract Acute pancreatitis (AP) is one of the most common acute abdominal diseases. The digestive disease committee, Chinese Association Integrative Medicine, released Integrated traditional and Western medicine for diagnosis treatment in 2010. 1 Since then, further studies great progress have been made by domestic foreign counterparts from perspective both AP, including classification, fluid resuscitation, organ function maintenance, surgery intervention, enteral nutrition (EN), syndrome...
Severity of acute pancreatitis contributes to the modality cell death. Pervious studies have demonstrated that herb medicine formula "Dachengqi Decoction" (DCQD) could ameliorate severity pancreatitis. However, biological mechanisms governing its action most remain unclear. The role apoptosis/necrosis switch within has attracted much interest, because induction apoptosis injured cells might suppress inflammation and disease. In this study, we used cerulein (10−8 M)-stimulated AR42J as an in...
Objectives To examine the effects of electroacupuncture (EA) on inflammatory responses in patients with acute pancreatitis (AP). Methods Eighty mild or severe AP were randomly allocated to a control group an EA group. All managed conservatively. In addition, received acupuncture for 30 min per day 7 days at bilateral points ST36, LI4, TE6, ST37 and LR3. Interleukin (IL)-6, IL-10 C-reactive protein (CRP) levels measured admission 7. The time re-feeding length stay hospital also recorded....
To explore the pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction (DCQD) in liver rats with severe acute pancreatitis (SAP) based on an herbal recipe tissue pharmacology hypothesis.Healthy male Sprague-Dawley were randomly divided into a sham operation group (SOG); model (MG); low-, median- high-dose treatment groups (LDG, MDG, HDG, respectively). Different dosages (6, 12 24 g/kg for LDG, respectively) DCQD administered to SAP. The concentrations aloe-emodin, rhein, emodin,...
Qing-Yi Decoction (QYD) has been used for severe acute pancreatitis (SAP) patients in China many years. There were two kinds of QYD: Num 1. QYD (QYD1) which is the response stage SAP and 2. (QYD2) second SAP. This study aims to evaluate therapeutic efficacy participants with In this prospective, randomized, double-blind, placebo-controlled trial, aged 18–70 years within first 7 days after onset typical abdominal pain (the definition was according 2007 Guidelines Management Severe Acute...
Objectives This study aimed to analyze active compounds and signaling pathways of CH applying network pharmacology methods, additionally verify the molecular mechanism in treating AP. Materials methods Network docking were firstly used identify components its potential targets treatment The pancreaticobiliary duct was retrogradely injected with sodium taurocholate (3.5%) create an acute pancreatitis (AP) model rats. Histological examination, enzyme-linked immunosorbent assay, Western blot...
Abstract Da‐Cheng‐Qi decoction (DCQD) is composed of dahuang, houpu, zhishi and mangxiao, while Xiao‐Cheng‐Qi (XCQD) just contains zhishi. A validated high‐performance liquid chromatographic (HPLC) method was developed for the determination pharmacokinetic comparison rhein in rats. It performed on a reversed‐phase C 18 column (150 × 4.6 mm) with mobile phase methanol 0.2% acetic acid (89:11, v/v) ultraviolet detection at 254 nm. The assay linear over range 30–3000 ng/mL ( r 2 = 0.9991), mean...
Severe acute pancreatitis (SAP) often develops into cardiac injury (ACI), contributing to the high mortality of SAP. Urolithin A (UA; 3,8-dihydroxy-6H-dibenzopyran-6-one), a natural polyphenolic compound, has been extensively studied and shown possess significant anti-inflammatory effects. Nevertheless, specific effects UA in SAP-associated (SACI) have not definitively elucidated. Here, we investigated therapeutic role mechanisms SACI using transcriptomics untargeted metabolomics analyses...
Dachengqi Tang (DT) is a common traditional Chinese medicine formula for expelling neire ('internal heat') in the stomach and intestines. There was no reliable analytical method available quality control of DT.A high-performance liquid chromatography (HPLC) with reverse phase C18 column (150 x 4.6 mm) developed. The mobile methanol 0.2% acetic acid. Eight markers including naringin, hesperidin, aloe emodin, rhein, honokiol, magnolol, emodin chrysophanol were determined.Regression analysis...