Immunotherapies represented by programmed cell death protein 1/programmed ligand 1 (PD-1/PD-L1) immune checkpoint inhibitors have made great progress in the field of anticancer treatment, but most colorectal cancer patients do not benefit from immunotherapy. Discoidin domain receptor (DDR1), a tyrosine kinase receptor, is activated collagen binding and overexpressed various malignancies. However, role DDR1 immunoregulation remains unclear. In this study, we found highly expressed tissues...

Abstract Purpose Guanylate binding protein 4 (GBP4) is induced by interferons and various cytokines has been recognized as functionally relevant in numerous types of human cancers. While the role GBP4 cancer preliminarily summarized, its correlation with antitumor immunity remains unclear requires further research. Methods First, a comprehensive pan-cancer analysis was conducted, focusing on GBP4’s expression patterns immunological functions. Subsequently, we explored correlations between...

Objectives To examine the effects of electroacupuncture (EA) on inflammatory responses in patients with acute pancreatitis (AP). Methods Eighty mild or severe AP were randomly allocated to a control group an EA group. All managed conservatively. In addition, received acupuncture for 30 min per day 7 days at bilateral points ST36, LI4, TE6, ST37 and LR3. Interleukin (IL)-6, IL-10 C-reactive protein (CRP) levels measured admission 7. The time re-feeding length stay hospital also recorded....

Background: Titanium (Ti) implants are widely used clinically, but peri-implantitis remains one of the most common and serious complications. Healthy integration between gingival tissue implant surface is critical to long-term success in dental therapy. The objective this study was investigate how different concentrations immobilized fibroblast growth factor 2 (FGF2) on titania nanotubular influence response human fibroblasts (HGFs). Methods: Pure Ti metal anodized at 20 V form a vertically...

The traditional Chinese formula Da-Cheng-Qi-decoction (DCQD) has been used to treat acute pancreatitis for decades. DCQD could ameliorate the disease severity and complications of organ injuries, including those liver lungs. However, pharmacological effects in kidney, a target organ, are still unclear. This study aimed investigate herbal tissue pharmacology kidney injury (AKI) rats with severe (SAP). Rats were randomly divided into sham-operation group (SG), model (MG) low-, medium-...

Dao-Chi powder (DCP) has been widely used in the treatment of inflammatory diseases clinical practice traditional Chinese medicine, but not acute pancreatitis (AP). This study aimed to evaluate effect DCP on severe AP (SAP) and SAP-associated intestinal cardiac injuries. To this end, an SAP animal model was established by retrograde injection 3.5% taurocholic acid sodium salt into biliopancreatic ducts rats. Intragastric (9.6 g/kg.BW) administered 12 h after modeling. The pancreas, duodenum,...

Abstract The cyclic adenosine monophosphate (cAMP) signalling pathway plays an important role in the regulation of development and pathogenicity filamentous fungi. cAMP‐dependent protein kinase A (PKA) is conserved element downstream cAMP, its diverse mechanisms multiple fungi are not well known yet. In present study, gene knockout mutants two catalytic subunits PKA (PKA‐C) Setosphaeria turcica were created to illustrate regulatory PKA‐Cs on S. . As a result, StPkaC2 was proved be main...

Objectives. The Chinese herbal medicine Da-Cheng-Qi Decoction (DCQD) can ameliorate the severity of acute pancreatitis (AP). However, potential pharmacological mechanism remains unclear. This study explored effective components and pharmacokinetic characteristics DCQD in target tissue experimental rats. Methods. Acute pancreatitis-like symptoms were first induced rats then they given different doses (6 g/kg, 12 24 g/kg body weight) orally. Tissue drug concentration, pathological score,...

As a main ingredient of milk, the nucleotides content is about 12-58 mg/g, which plays critical role in maintaining cellular function and lipid metabolism. This study was conducted to evaluate effects short-term uridine monophosphate (UMP) (UR) administration on metabolism early-weaned piglets. Twenty-one weaned piglets (7 d age; 3.32 ± 0.20 kg average body weight) were randomly assigned into three groups: The control (CON), UMP, UR group, oral administered UMP or for 10 days, respectively....

Obesity worsens inflammatory organ injury in acute pancreatitis (AP), but there is no effective preventive strategy. Sheng-jiang powder (SJP) has been shown to alleviate multiple-organ rats with high-fat diet-induced obesity. Hence, SJP supposed have an effect on AP fed a diet.To explore how obesity may contribute aggravating and observe the of diet.Rats were randomly assigned control group (CG), obese (OG), treatment (SG), eight per group. The OG SG diet. From third week, given oral doses...

ZNRD1, a new zinc ribbon gene, has been previously identified as an upregulated gene in multidrug-resistant gastric cancer cell line SGC7901/VCR comparing to its parental SGC7901 by subtractive hybridization and RT-PCR. The antisense nucleic acid for ZNRD1 could enhance adriamycin accumulation cells sensitize vincristine. present study aims explore the role of multidrug resistance caner cells. Upregulation protein was confirmed Western blot immunocytochmical staining. genetically...

Ovarian cancer is the second most common cause of gynecological death in women. It usually diagnosed late and accompanied by peritoneal metastasis. For ovarian with metastasis, intraperitoneal (IP) chemotherapy can maintain a high drug concentration abdominal cavity reduce local systemic toxicity. Recently, docetaxel (DTX) has shown broad-spectrum antitumor activity against various malignant tumors, including However, DTX limited clinical applications due to its poor water solubility,...

Yinhua pinggan granule (YHPGKL), a traditional Chinese medical compound, could treat pneumonia. Although previous studies demonstrated the protective and therapeutic effects of YHPGKL on pneumonia, its potential molecular mechanisms effective components are still elusive. Herein, we performed network pharmacology analysis to determine possible signaling pathways involved in YHPGKL. A total 119 257 target proteins were identified, among which 117 interacted with 113 related Then,...

Objective: Patients with hepatocellular carcinoma (HCC) in stage Barcelona Clinic Liver Cancer (BCLC)-A were grouped based on whether they accompanied hepatitis B virus (HBV) infection or not so as to explore the clinical characteristics and prognostic conditions of HCC patients non-HBV/hepatitis C (HCV). Materials Methods: Clinical data 64 BCLC-A non-HBV/HCV (observation group) who received radical hepatectomy Affiliated Hospital Guangxi Medical University from January, 2006 November, 2014...

The burden of cardiovascular disease is predicted to escalate in developing countries. aim this study assess the characteristics, management strategies and outcomes patients with acute coronary syndrome (ACS) who were admitted hospitals under chest pain center mode southwest P. R. China. Adults hospitalized a diagnosis ACS enrolled retrospective, observational registry between January 2017 June 2019 at 11 Chengdu, collected data included patients' baseline clinical in-hospital outcomes....

Malignant ascites (MA) is caused by intraperitoneal spread of solid tumor cells and results in a poor quality life. Chemotherapy common first-line treatment for patients with MA. Taxotere ® (DTX) widely used therapies. However, the low water solubility side effects additives formulation restrict clinical application docetaxel. HT001 stage docetaxel micelle developed to overcome issue improved safety profiles. To support development expand HT001, this study vitro vivo approaches investigate...

Ca 2+ -sensing receptors (CaSR), activated by elevated concentrations of extracellular , have been known to regulate functions thyroid cells, neurons, and endothelial cells (EC). In this report, we studied CaSR-mediated influx in mouse cerebral microvascular EC (bEND.3 cells). Cytosolic free concentration Mn were measured fura-2 microfluorometry. High (3 mM) (CaSR agonist), 3 mM spermine 10 μM cinacalcet (positive allosteric modulator CaSR) all triggered influx; however, spermine, unlike...

Background:Zornia diphylla (L.) Pers. (ZDP) is a traditional Chinese herbal medicine that has been used for several decades to treat patients with liver diseases. Whether ZDP best administered as single agent or adjunctive therapy yet be determined does the mechanism whereby it exerts its effects on antagonizing acute injury (ALI). Aim of study: To investigate protective ALI induced by carbon tetrachloride (CCl4) and potential underlying mechanisms. Materials Methods: Sixty adult mice were...