A5056003555- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Erythrocyte Function and Pathophysiology
- Hepatocellular Carcinoma Treatment and Prognosis
- IgG4-Related and Inflammatory Diseases
- Functional Brain Connectivity Studies
- Extracellular vesicles in disease
- Spine and Intervertebral Disc Pathology
- Gut microbiota and health
- Macrophage Migration Inhibitory Factor
- Diabetes Management and Research
- RNA modifications and cancer
- Diabetes and associated disorders
- Hepatitis B Virus Studies
- Otitis Media and Relapsing Polychondritis
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Nasolacrimal Duct Obstruction Treatments
- Cardiovascular Function and Risk Factors
- Abdominal vascular conditions and treatments
- Cervical and Thoracic Myelopathy
- Optimism, Hope, and Well-being
West China Hospital of Sichuan University
2016-2025
Sichuan University
2016-2025
Nanjing Medical University
2015-2024
Jiangsu Province Hospital
2024
Tianjin People's Hospital
2024
Dalian Medical University
2018
Chongqing Medical University
2018
Second Affiliated Hospital of Chongqing Medical University
2018
Severe acute pancreatitis-associated lung injury (SAP-ALI) is a serious disease associated with high mortality. Emodin has been applied to alleviate SAP-ALI; however, the mechanism remains unclear. We report that therapeutic role of emodin in attenuating SAP-ALI partly dependent on an exosomal mechanism. SAP rats had increased levels plasma exosomes altered protein contents compared sham rats. These infused tended accumulate lungs and promoted hyper-activation alveolar macrophages...
Objective: To investigate the protective effect of emodin in acute pancreatitis (AP)-associated lung injury and underlying mechanisms. Methods: NaT-AP model rats was constructed using 3.5% sodium taurocholate, CER+LPS-AP mice caerulein combined with Lipopolysaccharide. Animals were divided randomly into four groups: sham, AP, Ac-YVAD-CMK (caspase-1 specific inhibitor, AYC), groups. AP-associated assessed H&E staining, inflammatory cytokine levels, myeloperoxidase activity. Alveolar...
Purpose: Depression is common in Parkinson's disease (PD) and correlated with the severity of motor deficits quality life. The present study aimed to investigate alterations structural brain network related depression (d-PD) their correlations impairments white matter (WM). Materials Methods: Data were acquired from Parkinson Progression Markers Initiative (PPMI) database. A total 84 de novo drug-naïve PD patients screened classified into two groups according 15-item Geriatric Scale...
Abstract Aims To evaluate the clinical profile of patients with diabetic ketoacidosis in tertiary hospitals China. Methods A retrospective study hospitalized between 2010 and 2012 was carried out 15 around Clinical laboratory data were collected. Patients classified based on diagnosis treatment history. Groups compared for differences vital statistics biochemical profiles at presentation. Results The comprised 643 ketoacidosis: 308 (47.9%) Type 1 diabetes, 294 (45.7%) 2 diabetes 41 (6.4%)...
Dao-Chi powder (DCP) has been widely used in the treatment of inflammatory diseases clinical practice traditional Chinese medicine, but not acute pancreatitis (AP). This study aimed to evaluate effect DCP on severe AP (SAP) and SAP-associated intestinal cardiac injuries. To this end, an SAP animal model was established by retrograde injection 3.5% taurocholic acid sodium salt into biliopancreatic ducts rats. Intragastric (9.6 g/kg.BW) administered 12 h after modeling. The pancreas, duodenum,...
To investigate the clinical and pathological characteristics of chronic hepatitis B (CHB) with metabolic dysfunction-associated fatty liver disease (MAFLD), as well associations advanced fibrosis.
Background and Aims: Acute liver injury (ALI) often follows biliary acute pancreatitis (BAP), but the exact cause effective treatment are unknown. The aim of this study was to investigate role gut microflora–bile acids–liver axis in BAP‐ALI mice assess potential therapeutic effects Yinchenhao decoction (YCHD), a traditional Chinese herbal medicine formula, on BAP‐ALI. Methods: Male C57BL/6 were allocated into three groups: negative control (NC), BAP model, YCHD groups. severity BAP‐ALI,...
<title>Abstract</title> <bold>Objective: </bold>To identify the risk factors that influence prognosis of patients with cervical spondylotic myelopathy (CSM). <bold>Methods: </bold>Clinical data were collected from 103 CSM treated between January 2023 and 2024 in Department Orthopaedics at First Affiliated Hospital Nanjing Medical University. The retrospectively analyzed, a one-year follow-up. Based on Japanese Orthopaedic Association score, categorized into good poor recovery groups....
To study the clinicopathologic features of IgG4-related ocular disease and differentiated diagnosis with non-IgG4-related disorders.Forty-three cases were selected from Department Pathology, West China Hospital, Sichuan University December 2008 to January 2015 retrospective series case study. The clinical manifestation, laboratory examination, imaging findings, treatment histopathological characteristics analyzed. According diagnostic criteria for in 2014 relevant literatures, our divided...
Abstract Background: Emodin, one of the most dominant components traditional Chinese medicine rhubarb , has been utilized to treat acute pancreatitis (AP). Acute lung injury (ALI) is common complications pancreatitis, leading a serious mortality rate. However, specific mechanism emodin in treatment AP-associated remains unclear. Therefore, we investigated protective roles AP-ALI and its underlying mechanisms two clinically relevant experimental AP models. Methods: NaT-AP model rats was...