A5101674174- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Electrospun Nanofibers in Biomedical Applications
- Endometrial and Cervical Cancer Treatments
- Anesthesia and Neurotoxicity Research
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
- Phytochemicals and Antioxidant Activities
- Central Venous Catheters and Hemodialysis
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Cancer Treatment and Pharmacology
- Neonatal Respiratory Health Research
- Antioxidant Activity and Oxidative Stress
- Occupational and environmental lung diseases
- Phytochemical Studies and Bioactivities
- Gynecological conditions and treatments
- Facial Rejuvenation and Surgery Techniques
- Cancer Research and Treatments
- Tissue Engineering and Regenerative Medicine
- CAR-T cell therapy research
- Adipokines, Inflammation, and Metabolic Diseases
Sichuan University
2020-2025
West China Second University Hospital of Sichuan University
2020-2025
Hebei University of Science and Technology
2023-2025
Chinese Academy of Sciences
2025
Shanghai Zhabei District Shibei Hospital
2025
West China Hospital of Sichuan University
2021-2024
Meizhou City People's Hospital
2024
Central South University
2024
Xuzhou Medical College
2024
Huazhong University of Science and Technology
2024
Abstract Ferroptosis, a newly defined mode of regulated cell death caused by unbalanced lipid redox metabolism, is implicated in various tissue injuries and tumorigenesis. However, the role ferroptosis stem cells has not yet been investigated. Glutathione peroxidase 4 (GPX4) critical suppressor peroxidation ferroptosis. Here, we study function GPX4 hematopoietic progenitor (HSPCs) mice with Gpx4 deficiency system. We find that deletion solely system no significant effect on number HSPCs...
Ferroptosis, a type of cell death triggered by excessive accumulation iron-dependent lipid peroxidation, possesses an excellent potential in cancer treatment. However, many colorectal (CRC) lines are resistant to ferroptosis induced erastin and RSL3, the classical ferroptotic inducers. Moreover, underlying mechanism resistance remains poorly elucidated. This study sought discover major factor contributing CRC. The findings will help design strategies for triggering application individualized...
Ferroptosis is a novel form of programmed iron-dependent cell death. The ferroptosis-related genes (FRGs) have been recognized as biomarkers for cancers. Increasing evidence has indicated that ferroptosis involved in the process atherosclerosis. However, potential FRGs used diagnosis, prognosis and therapy atherosclerosis are still unclear. We aimed to identify differentially expressed (DEGs) downloaded mRNA-sequencing data patients with from Gene Expression Omnibus (GEO) database. HMOX1 was...
Air pollution, especially particle matter (PM) has caused serious damage to the environment and human health. Recently, polymer nanofiber air filter materials that can effectively remove PM have become one research hotspot. However, fabrication of with excellent removal efficiency at high temperatures is still a challenge. Herein, poly(m-phenyleneisophthalamide)/TiO2 (PMIA/TiO2) composite membrane superior for PM2.5 temperature stability was developed. The TiO2 nanoparticles were selected...
The core catalytic unit of telomerase comprises reverse transcriptase (TERT) and RNA (TERC). Unlike TERT, which is predominantly expressed in cancer stem cells, TERC ubiquitously normal somatic cells without activity. However, the functions these telomerase-negative remain elusive. Here, we reported positive feedback regulation between PI3K-AKT pathway that controlled cell proliferation independent activity human fibroblasts. Mechanistically, revealed activated transcription target genes...
To investigate the effects of dapagliflozin, in addition to standard therapy, on heart rate variability (HRV), soluble growth stimulation expressed gene 2 protein (sST2), N-terminal pro B-type natriuretic peptide (NT-proBNP), and echocardiographic parameters patients with early-onset post-myocardial infarction failure (HF). A total 98 HF were enrolled randomly divided into a control group (n = 48, receiving therapy) an observation 50, therapy plus dapagliflozin 10 mg daily). HRV, cardiac...
ABSTRACT Particulate matter (PM) pollution is widely recognized as a major threat to public health, making the development of thermally stable filters for particulate removal in high‐temperature environments critically important. However, common polymer‐based nanofiber air are inadequate stability when exposed high temperature. In this study, poly (m‐phenylene isophthalamide) (PMIA) and nano barium titanate (BaTiO 3 ) which showed remarkable thermal endurance was utilized prepare PMIA/BaTiO...
ABSTRACT Loss of RB1 function represents a defining characteristic triple‐negative breast cancer (TNBC) and is intricately associated with resistance to therapeutic interventions. In this study, we investigate the epigenetic mechanisms governing expression in TNBC. Employing combination bioinformatics analyses experimental validations, identified lysine histone methyltransferase EZH2 as key upstream regulator expression. primarily mediates trimethylation 27 on H3 catalytic subunit Polycomb...
The RNA component of human telomerase (hTR) localizes to Cajal bodies, and it has been proposed that bodies play a role in the assembly holoenzyme trafficking. Here, was examined Human cells deficient coilin (i.e. coilin-knockout (KO) cells), which no are detected. In coilin-KO cells, normal level activity is detected interactions between core factors preserved, indicating occurs absence bodies. Moreover, dispersed hTR aggregates forms foci specifically during S G2 phase cells....
Metal–organic frameworks (MOFs) featuring porous structures and large specific surface areas have shown great potential in removing organic pollutants from wastewater via adsorption processes. Although the particle size of MOFs determines performance (something known as size-dependent effect), engineering it into desirable dimensions for enhancing is a challenge. Here, we develop practical facile approach to regulate copper benzene-1,3,5-tricarboxylate (Cu-BTC) adsorbents with high...
Background: Our previous study has illuminated that PGC-1α downregulation promoted chronification of pain after burn injury. RNA-seq analysis predicted association between Sp1 and chronic constriction injury (CCI)-provoked neuropathic pain. Further ChIP-Atlas data investigation suggested the binding to PGC-1α. Thereby, we performed this illustrate functional relevance Sp1/PGC-1α axis in Methods: Neuropathic was induced by CCI vivo rats, followed assessment pain-like behaviors. The expression...
Dexmedetomidine (Dex) works as a crucial agent for the treatment of intestinal ischemia/reperfusion (I/R), but its mechanism remains unclear. Recent articles demonstrated pivotal role Janus kinase/signal transducer and activator transcription (JAK2/STAT3) signalling in I/R. Therefore, it is reasonable to explore associated JAK2/STAT3 Dex treatment. The study purpose was evaluate regulatory mechanisms preventing Anaesthetized rats were subjected superior mesenteric artery occlusion consisting...
Abstract Background Immune cells and stromal in the tumor microenvironment play a vital role progression of colorectal cancer (CRC). The study aimed to screen valuable prognostic biomarkers CRC based on immune scores. Method ESTIMATE algorithm was used calculate scores samples TCGA. Then were divided into high low score groups median value Differentially expressed genes (DEGs) associated with screened. WGCNA univariate COX regression analysis performed further identify key genes. Analysis...
Abstract Endometrial cancer (EC) constitutes a common female genital tract tumor with rising incidence rate. Sirtuin 1 (SIRT1) is member of histone deacetylase, which extensively participates in the progression aging, cell death, and tumorigenesis. This study explored effect SIRT1‐mediated LC3 acetylation on autophagy proliferation EC cells. SIRT1 expression tissues adjacent tissues, lines normal human epithelial cells was detected. elevated tissues. Knockdown inhibited proliferation,...