A5073836769- Pain Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Pharmacological Effects of Natural Compounds
- Voice and Speech Disorders
- Healthcare and Venom Research
- Airway Management and Intubation Techniques
- Tryptophan and brain disorders
- Thermal Regulation in Medicine
- Anesthesia and Sedative Agents
- Optical Imaging and Spectroscopy Techniques
- Pain Management and Placebo Effect
- Treatment of Major Depression
- Pain Management and Opioid Use
- Neurotransmitter Receptor Influence on Behavior
- Tracheal and airway disorders
Sir Run Run Shaw Hospital
2019-2025
Zhejiang University
2019-2025
University of Science and Technology of China
2025
Center for Pain and the Brain
2018-2019
Harvard University
2018-2019
Massachusetts General Hospital
2018-2019
Huazhong University of Science and Technology
2013
Tongji Hospital
2013
Postoperative cognitive dysfunction (POCD) is frequently observed in elderly patients following anesthesia, but its pathophysiological mechanisms have not been fully elucidated. Sevoflurane was reported to repress autophagy aged rat neurons; however, the role of mitophagy, which crucial for control mitochondrial quality and neuronal health, sevoflurane-induced POCD rats remains undetermined. Therefore, this study investigated whether mitophagy impairment involved dysfunction. We found...
Abstract Background Neuropathic pain is related to the sustained activation of neuroglial cells and production proinflammatory cytokines in spinal dorsal horn. However, clinical efficacy currently available treatments very limited. The transcription factor nuclear κB (NF-κB) a ubiquitously expressed protein family considered be crucial autoimmunity. Thus, our study aimed examine influence NF-κB p65 chronic constriction injury (CCI)-induced neuropathic as well its underlying mechanism....
Expiratory central airway collapse is a degenerative tracheobronchial disease that often overlooked because of its nonspecific clinical features. A man was admitted for evaluation tracheal nodules. Following bronchoscopic biopsy, significant increase in pressure occurred during anesthesia recovery. Laryngospasm suspected, and intubation performed. Bronchoscopy revealed an almost completely collapsed lumen. Y-shaped silicone stent placed using rigid bronchoscope to support the airway,...
Background: Our previous study has illuminated that PGC-1α downregulation promoted chronification of pain after burn injury. RNA-seq analysis predicted association between Sp1 and chronic constriction injury (CCI)-provoked neuropathic pain. Further ChIP-Atlas data investigation suggested the binding to PGC-1α. Thereby, we performed this illustrate functional relevance Sp1/PGC-1α axis in Methods: Neuropathic was induced by CCI vivo rats, followed assessment pain-like behaviors. The expression...
BACKGROUND: Tissue injuries such as surgery and trauma are usually accompanied by simultaneous development of acute pain, which typically resolves along with tissue healing. However, in many cases, pain does not resolve despite proper repair; rather, it transitions to chronic pain. In this study, we examined whether proliferator-activated receptor-gamma coactivator-1α (PGC-1α), a master regulator mitochondria biogenesis, is implicated chronification after burn injury mice. METHODS: We used...
BACKGROUND: As opioid abuse and addiction have developed into a major national health crisis, prescription of opioids for pain management has become more controversial. However, do help some patients by providing relief improving the quality life. To better understand addictive properties under chronic conditions, we used conditioned place preference (CPP) paradigm to examine rewarding morphine in rats with persistent nociception. METHODS: Spared nerve injury (SNI) model was induce...
Ketamine is known to have a rapid and lasting antidepressant effect. Recent studies shown that ketamine exerts it effect by blocking burst firing in the lateral habenula (LHb). Whether sustained of occurs through same mechanism has not been explored. Here, using male rats, we found local infusion (R,S)-ketamine into LHb resulted antidepressant-like 1 h after infusion, which almost returned baseline levels 24 h. Intra-LHb injection (S)-ketamine also showed significant injection, recovered at...