A5010157362- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
- Cardiovascular Issues in Pregnancy
- Blood Coagulation and Thrombosis Mechanisms
- Reproductive System and Pregnancy
- Circular RNAs in diseases
- Autoimmune and Inflammatory Disorders Research
- Streptococcal Infections and Treatments
- Vasculitis and related conditions
- Pregnancy and preeclampsia studies
- Peptidase Inhibition and Analysis
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Respiratory viral infections research
- COVID-19 Impact on Reproduction
- Pneumonia and Respiratory Infections
- Neonatal and Maternal Infections
- Angiogenesis and VEGF in Cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Gestational Diabetes Research and Management
- COVID-19 Clinical Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
Guangzhou Medical University
2015-2025
Guangzhou Women and Children Medical Center
2014-2025
Care Resource
2020-2024
State Key Laboratory of Respiratory Disease
2020-2024
South China University of Technology
2022
Guangdong Province Women and Children Hospital
2021
Sun Yat-sen University
2011-2021
Institute of Clinical Research
2018
Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high heritability, shows differences in prevalence, severity and age of onset among different ancestral groups. Previous genetic studies have focused more on European populations, which appear to be the least affected. Consequently, variations that underlie commonalities, treatment options SLE groups not been well elucidated. To address this, we undertake genome-wide association study, increasing sample size Chinese...
MYCN amplification is tightly associated with the poor prognosis of pediatric neuroblastoma (NB). The regulation NB cell death by represents an important aspect, as it directly contributes to tumor progression and therapeutic resistance. However, relationship between remains elusive. Ferroptosis a newly identified mode featured lipid peroxide accumulation that can be attenuated GPX4, yet whether how regulates ferroptosis are not fully understood. Here, we report MYCN-amplified cells...
Upon arterial injury, endothelial denudation leads to platelet activation and delivery of multiple agents (e.g., TXA2, PDGF), promoting VSMC dedifferentiation proliferation (intimal hyperplasia) during injury repair. The process resolution vessel repair, prevention excessive repair (switching VSMCs back a differentiated quiescent state), is poorly understood. We now report that internalization APs by promotes switching on quiescence. Ex vivo in studies using lineage tracing reporter mice...
Diabetic foot ulcer (DFU) caused by impaired wound healing is a common vascular complication of diabetes. The current study revealed that plasma levels pigment epithelium–derived factor (PEDF) were elevated in type 2 diabetic patients with DFU and db/db mice. To test whether PEDF contribute to skin wound-healing delay diabetes, endogenous was neutralized an anti-PEDF antibody Our results showed neutralization accelerated healing, increased angiogenesis the skin, improved functions numbers...
Community-acquired pneumonia (CAP) contributes substantially to morbidity and mortality in children under the age of 5 years. In examining bronchoalveolar lavages (BALs) with CAP, we found that interleukin-17 (IL-17) production was significantly increased severe CAP. Immune profiling showed mucosal-associated invariant T (MAIT) cells from BALs, but not blood, CAP patients actively produced IL-17 (MAIT17). Single-cell RNA-sequencing revealed MAIT17 resided a BAL-resident PLZFhiCD103+ MAIT...
Keratin 6A (KRT6A) belongs to the keratin protein family which is a critical component of cytoskeleton in mammalian cells. Although KRT6A upregulation non-small cell lung cancer (NSCLC) has been reported, regulatory mechanism and functional role NSCLC development have less well investigated. In this study, was confirmed be highly expressed tissue samples, its high expression correlated with poor patient prognosis. Furthermore, overexpression promotes proliferation invasion. Mechanistically,...
We have previously reported on the potential pathogenic role of neutrophils in biliary atresia (BA). Herein, we aimed to delineate CD177+ pathogenesis BA.Immune cells from livers mice with rhesus rotavirus-induced BA were analysed. Single-cell RNA-sequencing was performed specifically analyse Gr-1+ (Ly6C/Ly6G+) liver. Gene expression profiles analysed using Smart-Seq method, and examined Cd177-/- mice. Neutrophil extracellular trap (NET) inhibitors used determine cell-derived NETs...
Background Echovirus type 11(E-11) can cause fatal haemorrhage-hepatitis syndrome in neonates. This study aims to investigate clinical risk factors and early markers of E-11 associated neonatal syndrome. Methods is a multicentre retrospective cohort 105 neonates with infection China. Patients (the severe group) were compared those mild disease. Clinical analysed. In addition, cytokine analysis performed selective patients explore the immune responses. Results addition prematurity, low birth...
Adenoidal hypertrophy (AH) is commonly observed in childhood and closely linked to obstructive sleep apnea (OSA). Despite the high prevalence of AH, its pathophysiological mechanisms remain incompletely understood. We attempt explore this issue from a genetic perspective. Elevated levels LINC00461 have been identified OSA tissues. aimed relationship between susceptibility adenoid gene polymorphisms. genotyped single nucleotide polymorphisms (SNPs) rs933647 rs201864123 546 AH patients 574...
Without therapeutic intervention, corneal neovascularization rapidly compromises visual acuity, and is a leading cause of blindness. Artesunate was reported to inhibit angiogenesis in tumors, although, the effects artesunate on nontumor have not been investigated. This study designed investigate effect delineate its underlying mechanism action.Rats with alkali-burned corneas were treated for 11 days. Corneal evaluated by measuring length area vasculature rats. Apoptotic cells stained...
Abstract The ability to identify a specific type of leukemia using minimally invasive biopsies holds great promise improve the diagnosis, treatment selection, and prognosis prediction patients. Using genome-wide methylation profiling machine learning methods, we investigated utility CpG status differentiate blood from patients with acute lymphocytic (ALL) or myelogenous (AML) normal blood. We established panel that can distinguish ALL AML as well high sensitivity specificity. then developed...
Nasopharyngeal carcinoma (NPC) is a type of epithelial malignancy known for its high likelihood metastasizing to distant organs, which remains the primary obstacle in treatment NPC. The present study aimed identify potential intervention target NPC metastasis.
SERPINA3K, also known as kallikrein-binding protein (KBP), is a serine proteinase inhibitor with anti-inflammatory and anti-angiogenic activities. Our previous studies showed that SERPINA3K inhibited proliferation in dose-dependent manner induced apoptosis of endothelial cells but had no influence on SGC-7901 gastric carcinoma or HepG2 hepatocarcinoma cells. However, it unknown whether has direct impact other which mechanisms are involved. In this study, we report for the first time not only...
Cardiovascula disease and recurrent miscarriage have shared risk factors, some cardiovascular disease-related candidate genes been confirmed to be associated with miscarriage. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA (lncRNA) that considered susceptibility disease. However, whether lncRNA MALAT1 polymorphisms are related unclear. We genotyped three (rs591291, rs619586, rs3200401) in 284 patients 392 controls using TaqMan methods. Logistic...
Background . Kawasaki disease (KD) is a systemic form of self-limited vasculitis in children less than five years old, and the main complication coronary artery injury. However, etiology KD remains unclear. The IL-1B polymorphisms rs16944 GG rs1143627 AA their diplotype GA/GA have been associated with significantly increased risk intravenous immunoglobulin (IVIG) resistance Taiwanese population, but relationship between A/G G/A lesions (CALs) patients has not investigated. present study...
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy ubiquitously associated with Epstein-Barr virus (EBV). EBV generates various viral microRNAs (miRNAs) by processing the BHRF1 and BamHI A rightward (BART) transcripts. These BART miRNAs are abundantly expressed in NPC, but their functions molecular mechanisms remain largely unknown. Our study found that EBV-encoded microRNA BART-22 was significantly upregulated NPC tissues positively correlated tumor progression. Furthermore, we...