A5034849186- Pediatric Hepatobiliary Diseases and Treatments
- Infant Nutrition and Health
- Congenital Anomalies and Fetal Surgery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Electrospun Nanofibers in Biomedical Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pancreatic and Hepatic Oncology Research
- Neonatal Health and Biochemistry
- Cytomegalovirus and herpesvirus research
- RNA modifications and cancer
- Autism Spectrum Disorder Research
- Nutrition, Genetics, and Disease
- Neonatal and Maternal Infections
- Social and Behavioral Studies
- Acute Kidney Injury Research
- Tissue Engineering and Regenerative Medicine
- Obsessive-Compulsive Spectrum Disorders
- Organ Transplantation Techniques and Outcomes
- Maternal Mental Health During Pregnancy and Postpartum
- Urological Disorders and Treatments
- Gallbladder and Bile Duct Disorders
Guangzhou Medical University
2018-2024
Wuhan Institute of Virology
2024
Chinese Academy of Sciences
2024
University of Arkansas for Medical Sciences
2019
Shanghai Mental Health Center
2015
Shanghai Jiao Tong University
2015
We have previously reported on the potential pathogenic role of neutrophils in biliary atresia (BA). Herein, we aimed to delineate CD177+ pathogenesis BA.Immune cells from livers mice with rhesus rotavirus-induced BA were analysed. Single-cell RNA-sequencing was performed specifically analyse Gr-1+ (Ly6C/Ly6G+) liver. Gene expression profiles analysed using Smart-Seq method, and examined Cd177-/- mice. Neutrophil extracellular trap (NET) inhibitors used determine cell-derived NETs...
This study was designed to investigate the regulatory effect of hyaluronic acid (HA)-coating silk fibroin (SF) nanofibers during epithelialization urinary tract for urethral regeneration. The obtained electrospun biomimetic tubular HA-SF nanofiber scaffold is composed a dense inner layer and porous outer in order mimic adhesion cavernous layers native tissue, respectively. A thin HA-gel coating fixed wall provide SF with smooth surface nano-topography higher hydrophilicity. Compared pure...
Our previous study indicated that CD177+ neutrophil activation has a vital role in the pathogenesis of biliary atresia (BA), which is partially ameliorated by N-acetylcysteine (NAC) treatment. Here, we evaluated clinical efficacy NAC treatment and profiled liver-resident immune cells via single cell RNA-sequencing (scRNA-seq) analysis to provide comprehensive landscape NAC-derived regulation.A pilot was conducted evaluate potential effects intravenous on infants with BA, 3-month follow-up...
Highlights•CD14 facilitates perinatal HCMV infection in biliary epithelial cells (BECs) via CD55.•PARP-1-mediated cell death was detected CMV-infected BECs.•CD14 knockout delays the onset of illness and reduces MCMV-induced bile duct damage mice.•Administration anti-mouse CD14 antibody PARP-1 inhibitor treatment MCMV-infected mice resulted amelioration reduced mortality.AbstractBackground & AimsA high human cytomegalovirus (HCMV) rate accompanied by an increased level is observed period. The...
Biliary atresia (BA) is the most common cause of endstage liver disease in infants with poor prognosis and high mortality. The etiology BA still unknown, but genetic factors have been considered as an important player BA. We investigated association two cis-regulated variants CD14 (rs2569190) NOTCH2 (rs835576) susceptibility, using largest case-control cohort, totaling 506 patients 1,473 healthy controls a Southern Chinese population. Significant epistatic interaction between our samples was...
Objective To evaluate the prevalence of anxiety disorder among China mainland residents in studies published from 1982 to 2012 through meta-analysis. Methods According predefined selection criteria and exclusion criteria,epidemiological during 2012,on disorders general population were identified searching Chinese Biological Medical Literature Database,Chongqing VIP database for Technical Periodicals,Wanfang Database,Chinese National Knowledge Infrastructure,EMBASE Pub Med.Hand...
Background: Biliary atresia (BA) is the most common cause of end-stage liver disease in infants with poor prognosis and high mortality. The etiology BA still unknown, but genetic factors have been considered as an important player BA.
Introduction/Purpose. DNA methylation plays a significant role in both the development and progression of various cancers. Although aberrant CpG islands is common epigenetic alternation found cancers, interpretation observed cancer risk remains challenge. typically mediated by Methyltransferases (DNMTs). This study took advantage infrastructure existing data samples Arkansas Rural Community Health (ARCH) Study cohort to conduct pilot nested case-control breast among African Americans...