A5014894153- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Intestinal Malrotation and Obstruction Disorders
- Congenital Diaphragmatic Hernia Studies
- Pancreatitis Pathology and Treatment
- Amoebic Infections and Treatments
- Biliary and Gastrointestinal Fistulas
- Congenital Anomalies and Fetal Surgery
- Neonatal Health and Biochemistry
- Organ Transplantation Techniques and Outcomes
- Tracheal and airway disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Esophageal and GI Pathology
- Infant Nutrition and Health
- Neonatal and Maternal Infections
- Acute Kidney Injury Research
- Cytomegalovirus and herpesvirus research
Guangzhou Women and Children Medical Center
2020-2025
Guangzhou Medical University
2013-2025
Liuzhou Maternal and Child Health Hospital
2025
We have previously reported on the potential pathogenic role of neutrophils in biliary atresia (BA). Herein, we aimed to delineate CD177+ pathogenesis BA.Immune cells from livers mice with rhesus rotavirus-induced BA were analysed. Single-cell RNA-sequencing was performed specifically analyse Gr-1+ (Ly6C/Ly6G+) liver. Gene expression profiles analysed using Smart-Seq method, and examined Cd177-/- mice. Neutrophil extracellular trap (NET) inhibitors used determine cell-derived NETs...
Abstract Background/Purpose Fetal hilar cyst is primarily diagnosed as two diseases after birth, cystic biliary atresia (CBA) and choledochal (CC). The aim of our study was to explore more reliable indicators in early differential diagnosis these cysts. Methods We recruited a total 50 cases with prenatal hepatic at three centers, patients were divided into CBA group ( n = 16) CC 34) according postnatal intraoperative diagnosis. Patient features, maximal diameter measured by ultrasonography...
Background: Single-port laparoscopic choledochal cyst (CDC) excision and Roux-en-Y hepaticoenterostomy (SPCH) exhibits several advantages over conventional techniques in the management of CDCs. However, performing small-diameter hepaticojejunostomy during single-port laparoscopy presents significant challenges, thereby increasing risk anastomotic complications. In this study, we employed mucosal eversion (ME) technique to alleviate difficulties associated with executing SPCH report...
There is currently no consensus on the timing of operative correction for patients with a prenatal diagnosis choledochal cyst (CDC). This study aims to retrospectively analyze prenatally diagnosed CDCs identify optimal and importance size as predictor appearance symptoms related CDC.We reviewed 125 CDC who were admitted Guangzhou Women Children's Medical Center from July 2015 2020. After dividing into symptomatic group (n = 37) an asymptomatic 88), according whether they had any clinical at...
Our previous study indicated that CD177+ neutrophil activation has a vital role in the pathogenesis of biliary atresia (BA), which is partially ameliorated by N-acetylcysteine (NAC) treatment. Here, we evaluated clinical efficacy NAC treatment and profiled liver-resident immune cells via single cell RNA-sequencing (scRNA-seq) analysis to provide comprehensive landscape NAC-derived regulation.A pilot was conducted evaluate potential effects intravenous on infants with BA, 3-month follow-up...
Activation of innate immunity together with cholangiocyte damage occurs in biliary atresia (BA). However, detailed information on the inflammatory cells involved is lacking. This study investigates both pathophysiology CD11b+Gr-1+ a mouse model BA and their presence patients. were targeted by an anti-Ly6G antibody murine induced inoculation rhesus rotavirus. Expression Ly6G homolog CD177+ was examined biopsies from The symptoms ameliorated, survival prolonged those mice receiving 5 to 10 μg...
Postoperative cholangitis (PC) is the most common and serious complication of biliary atresia (BA) patients post-Kasai portoenterostomy (KPE). The duration prophylactic intravenous antibiotics (IVA) after KPE varies with no clear consensus. We conducted a retrospective cohort study to explore effects IVA on preventing post-operative analyze risk factors for short-term prognosis.All diagnosed BA received in Guangzhou Women Children's Hospital 2018, were included this study. KPE. Firstly,...
Delayed diagnosis and inaccurate judgment of the severity disease may be principal reasons for poor prognosis associated with neonatal midgut volvulus. We aimed to develop a nomogram model that timely assesses risks intestinal ischemia necrosis in neonate retrospectively analyzed clinical data from neonates volvulus who were admitted Guangzhou Women Children's Medical Center January 2009 December 2019. Univariate multivariate analyses used obtain independent factors build predictive model....
Background: The feasibility, benefit, and safety of multiport laparoscopic choledochal cyst (CDC) excision Roux-en-Y hepaticoenterostomy (MPCH) have been consistently confirmed. Single-port CDC (SPCH) has advantages less traumatic more cosmetic beneficial, it reported in some case series, but is technically challenging. We propose a modified technique to reduce technical difficulty performing SPCH. feasibility SPCH were compared with those conventional excision.
Abstract Purpose To investigate the relationship between cytomegalovirus (CMV) infection and biliary atresia (BA) onset, development short-term prognosis after Kasai operation. Methods A retrospective study was conducted. BA Patients with obstructive jaundice tested for CMV were included grouped by CMV-IgM CMV-DNA test results, between-group differences of preoperative blood tests indicators investigated statistical significance. Results rate higher in patients compared non-BA jaundiced...