A5100425697- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Cardiovascular Issues in Pregnancy
- Inflammasome and immune disorders
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Biosensors and Analytical Detection
- Autoimmune and Inflammatory Disorders Research
- Vasculitis and related conditions
- Extracellular vesicles in disease
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Peptidase Inhibition and Analysis
- Identification and Quantification in Food
- Bacteriophages and microbial interactions
- Abdominal vascular conditions and treatments
- Drug Transport and Resistance Mechanisms
- Oral microbiology and periodontitis research
- Pediatric Hepatobiliary Diseases and Treatments
- Virus-based gene therapy research
- Congenital Heart Disease Studies
- Galectins and Cancer Biology
- Berberine and alkaloids research
- Vibrio bacteria research studies
- Bacterial Infections and Vaccines
Qingdao Women and Children's Hospital
2025
Qingdao University
2025
Guangzhou Medical University
2015-2024
Guangzhou Women and Children Medical Center
2013-2022
Xinjiang Production and Construction Corps
2019
Zunyi Medical University
2019
Sinotech Genomics (China)
2019
Institute of Clinical Research
2018
Stomatology Hospital
2016
Peking University
2016
Kawasaki disease (KD) is an acute vasculitis of early childhood that can result in permanent coronary artery structural damage. The cause for this arterial vulnerability up to 15% patients with KD unknown. Vascular smooth muscle cell dedifferentiation play a key role the pathophysiology medial damage and aneurysm formation, recognized pathology KD. Platelet hyperreactivity also hallmark We recently demonstrated uptake platelets platelet-derived miRNAs influences vascular phenotype vivo.
<title>Abstract</title> <bold>Importance:</bold> The association between gestational age (GA) and overweight/obesity risk has been studied in preterm infants, but remains underexplored term who account for the majority of live births. <bold>Objective: </bold>To determine whether early-term (GA 37-38 weeks) or full-term 39-40 delivery is associated with early childhood overweight obesity risk. <bold>Design, SETTING, AND PARTICIPANTS: </bold>This cohort study included healthy infants 37-40...
Abstract Although Kawasaki disease is the main cause of acquired heart in children, no diagnostic biomarkers are available. We aimed to identify candidate for diagnosing using serum exosomal microRNAs (miRNAs). Using frozen samples from a biobank, high-throughput microarray technologies, two-stage real-time quantitative PCR, and self-referencing strategy data normalization, we narrowed down list biomarker candidates set 4 miRNAs. further validated capabilities identified miRNAs (namely, C T...
Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy that often resistant to therapy. Nowadays, chemotherapy still one of the main methods for treatment ESCC. However, multidrug resistance (MDR)-mediated leading causes death. Exploring agents able reverse MDR, which thereby increase sensitivity with clinical first-line drugs, could significantly improve cancer treatment. Cepharanthine hydrochloride (CEH) has ability MDR in ESCC and mechanism involved have not been reported....
Background: To study the protein profile of serum exosomes patients with coronary artery aneurysms (CAA) caused by Kawasaki disease (KD). Methods: Two-dimensional electrophoresis (2-DE) was used to identify proteins from obtained children CAA KD, as well healthy controls. Differentially expressed were identified using matrix-assisted laser desorption/ionization time-of-flight/timeof-flight mass spectrometry (MALDI-TOF/TOF MS) analysis. Results: Thirty two differentially (18 up-regulated and...
Background . Kawasaki disease (KD) is a systemic form of self-limited vasculitis in children less than five years old, and the main complication coronary artery injury. However, etiology KD remains unclear. The IL-1B polymorphisms rs16944 GG rs1143627 AA their diplotype GA/GA have been associated with significantly increased risk intravenous immunoglobulin (IVIG) resistance Taiwanese population, but relationship between A/G G/A lesions (CALs) patients has not investigated. present study...
INTRODUCTION: The objective of this study was to investigate the possible link between influenza (Flu) infection and Kawasaki disease (KD). METHODS: We examined medical records 1,053 KD cases 4,669 hospitalized at our institute from January 1, 2011 December 31, 2013. Cases with concomitant formed + Flu group. Each case matched 2 cases, these were assigned group group, respectively. differences in principal clinical manifestations, course disease, incomplete rate, intravenous immunoglobulin...
Aim To explore whether aspirin is necessary for treatment in the acute phase of Kawasaki disease (KD). Methods Nine hundred ten patients who fulfilled criteria KD and maintained follow‐up 2 years were included this retrospective study. All initially received a single dose intravenous immunoglobulin (IVIG, g/kg) phase. Patients classified into three groups according to doses aspirin. Group 1 152 cases treated with IVIG only 672 plus 3–5 mg/kg/day as low‐dose group, group 3 86 30–50...
ABSTRACT Kawasaki disease (KD) is a systemic vasculitis syndrome that leads to coronary artery aneurysm (CAA). While echocardiography the most important imaging modality for assessment, specific diagnostic biomarker complementary CAA has not been reported. We aimed analyze profiles of exosomal miRNAs extracted from serum KD patients and controls identify candidate biomarkers CAA. Serum samples 39 healthy children, 42 patients, 38 dilatation (CAD) 45 virus‐infected including 24 EBV 21 ADV...
Food safety and foodborne infections diseases have been a leading hotspot in public health, methicillin-resistant Staphylococcus aureus (MRSA) has recently documented to be an important pathogen, addition its recognition clinical pathogen for some decades. Standard identification MRSA commonly performed both settings food routine detection; however, most of such so-called “standards,” “guidelines,” or “gold standards” are incapable detecting viable but non-culturable (VBNC) cells. In this...
The aim of this study was to investigate the serum exosome proteome profile coronary artery dilatation (CAD) caused by Kawasaki disease (KD). Two-dimensional electrophoresis implemented on proteins exosomes obtained from children with CAD KD and healthy controls. Differentially expressed were identified matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry analysis. We 38 differentially (13 up-regulated 25 down-regulated) patients compared Expression...
Kawasaki disease, which is characterised by systemic vasculitides accompanied acute fever, regularly treated intravenous immunoglobulin to avoid lesion formation in the coronary artery; however, mechanism of therapy unclear. Hence, we aimed analyse global expression profile serum exosomal proteins before and after administering immunoglobulin.Two-dimensional electrophoresis coupled with mass spectrometry analysis was used identify differentially expressed proteome exosomes patients disease...
Kawasaki disease is a kind of systemic vasculitis that mainly damages moderate and small-sized blood vessels, leading cause coronary artery lesions (CAL). Antiplatelet therapy routine component treatment strategies. So it important to evaluate the antiplatelet effect aspirin because individual biological variability aspirin. The immature platelet fraction (IPF) has attracted particular attention as may influence This study investigated prognostic factors for evaluating degree in children...
Parapharyngeal abscess (PPA)-like lesion is a very rare manifestation of Kawasaki disease (KD). Here we report Chinese case KD initially mimicking PPA, which the first one reported in Asia.A 3-year-old male patient presented with fever, drooling, and bilateral painful cervical lymphadenopathy for 3 days. Chest X-ray echocardiogram were normal. With substantial elevation white blood count C-reactive protein, purulent lymphadenitis was considered. Symptoms did not improve after treatment...
There have been no robust data from clinical trials to guide the clinician in choice of therapeutic agents for child with intravenous immunoglobulin (IVIG) resistance. The treatment regimen IVIG-resistant patients varies between institutions, and best option has not yet established. Therefore, this trial, a total 955 Kawasaki disease (KD) were selected initially treated IVIG (2 g/kg), whom 80 (8.38%) assessed as resistant randomly divided into two groups: Group A received second ( <a:math...
Background. Although intravenous immunoglobulin (IVIG) is expected to prevent coronary artery abnormalities of Kawasaki disease (KD) in the acute phase, timing and effectiveness IVIG remain be determined. The association administration KD patients with evaluated this cohort study. Methods. We systematically studied from two participating institutions between 2015 2017. To reveal treatment, these were classified into four groups regarding time treatment. Primary outcome was by echo at...
Kawasaki disease (KD) is an acquired cardiac with a high incidence that affects children. KD has various complications, including coronary artery dilation (CAD) and aneurysms (CAA). The identification of differentially expressed proteins the underlying mechanisms may be key to understanding differences between these complications. In present study, isobaric tags for relative absolute quantitation were used identify variations in serum patients CAD CAA. total, 87 (37 upregulated 50...
Abstract Kawasaki disease (KD) is an acute systemic vasculitis that most seriously complicated by coronary artery aneurysm (CAA). The polymorphisms of platelet endothelial aggregation receptor 1 ( PEAR1 ), notably rs12041331 and rs12566888 , were found to be closely related cardiac disease. However, little known regarding the connection between KD. In this study, we genotyped in 637 healthy infants 694 KD patients (74 with CAA). Subsequently, odds ratio (OR) 95% confidence interval (CI)...
To test the reliability and validity of dermatology life quality index (DLQI) in simplified Chinese language by assessing (QoL) HIV (human immunodeficiency virus)/AIDS (Acquired syndrome) patients with pruritic papular eruption (PPE). A study simplified-Chinese-version DLQI was carried out Henan province, China. The were tested means statistical method. Data processed SPSS 19.0. One hundred seven subjects participated 106 (99.07%) finished questionnaire. Eighteen mildly affected; 62...
Background . Kawasaki disease (KD) is an acute vasculitis that commonly causes acquired heart in children. Coronary artery aneurysm (CAA) a major complication of KD. However, the pathogenesis KD remains unclear. The results genome-wide association study (GWAS) showed two functional single-nucleotide polymorphisms (SNPs; rs699A>G and rs5050T>G) angiotensinogen (AGT) gene were related to cardiovascular susceptibility. purpose our was estimate relationship between GWAS-identified AGT risk...