A5103055438- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Infections and Vaccines
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Kawasaki Disease and Coronary Complications
- Enterobacteriaceae and Cronobacter Research
- Coronary Artery Anomalies
- Hepatitis C virus research
- Biosensors and Analytical Detection
- Systemic Lupus Erythematosus Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Vibrio bacteria research studies
- Salmonella and Campylobacter epidemiology
- Pharmaceutical and Antibiotic Environmental Impacts
- Sepsis Diagnosis and Treatment
- Microbial Metabolism and Applications
- Acute Myocardial Infarction Research
- Cancer Research and Treatments
- Cardiovascular Issues in Pregnancy
Guangzhou Medical University
2010-2023
Guangzhou Women and Children Medical Center
2008-2018
Institute of Clinical Research
2018
Boston Children's Hospital
2009
Abstract Background Quinolone resistance in Enterobacteriaceae results mainly from mutations type II DNA topoisomerase genes and/or changes the expression of outer membrane and efflux pumps. Several recent studies have indicated that plasmid-mediated mechanisms also play a significant role fluoroquinolone resistance, its prevalence is increasing worldwide. In China, presence qnr gene clinical isolates has been reported, but this transmissible quinolone not detected strains isolated singly...
Neonatal invasive disease caused by group B Streptococcus (GBS) represents a significant public health care concern globally. However, data related to burden, serotype distribution, and molecular epidemiology in China other Asian countries are very few specifically relative confined regions. The aim of this study was investigate the genetic characteristics GBS isolates recovered from neonates with during 2013-2014 at Guangzhou Changsha hospitals southern mainland China. We assessed capsular...
The prevalent Staphylococcus aureus clones and antibiotic susceptibility profiles are known to change dynamically geographically; however, recent S. strains causing infections in women children China have not been characterized. In this study, we analyzed the molecular epidemiology antimicrobial resistance of isolated from patients four centers for Guangzhou, China. total, 131 isolates (100 31 women) were by spa typing, multi-locus sequence virulence gene profiling, staphylococcal...
Nontyphoidal Salmonella (NTS) is a common pathogen responsible for acute gastroenteritis among all ages; however, information on the prevalence, serotypes, and antibiotic susceptibility of NTS isolates limited. We aimed to explore characteristics isolated from paediatric patients in Guangzhou, China. This was retrospective study 4586 stool culture collected at Guangzhou Women Children's Medical Center 2014 2016. identified 220 (4.80%) samples. Fourteen serotypes were isolates. serotype...
Invasive group B Streptococcus (GBS) remains a leading cause of illness and death among infants globally. We conducted prospective retrospective laboratory-based surveillance GBS-positive cultures from <3 months age in 18 hospitals across China during January 1, 2015-December 31, 2017. The overall incidence GBS was 0.31 (95% CI 0.27-0.36) cases/1,000 live births; 0-0.76 births participating hospitals. case-fatality rate 2.3%. estimated 13,604 cases 1,142 GBS-associated deaths <90 days...
Group B Streptococcus (GBS) is a leading cause of morbidity and mortality in infants both developed developing countries. To our knowledge, only few studies have been reported the clinical features, treatment outcomes GBS disease China. The severity neonatal China remains unclear. Population-based surveillance therefore required.We retrospectively collected data <3 months old with culture-positive sterile samples from three large urban tertiary hospitals South Jan 2011 to Dec 2014. isolates...
Three kinds of PMQR determinants (qnr genes, aac(6')-Ib-cr, and qepA) have been discovered shown to be widely distributed among clinical isolates. To characterize the prevalence in ESBL or AmpC-producing E. coli isolates Chinese children, a total 292 collected from five children's hospitals China 2005 2006 were screened for by PCR. Twenty (6.8%) positive determinants. A 12 (4.1%) qnr comprising three qnrA (1.0%), qnrB six qnrS (2.1%). Twenty-four (8.2%) aac(6')-Ib, which 10 (3.4% 292) had...
New Delhi metallo-β-lactamase-1 (NDM-1) is a novel type of metallo-β-lactamase (MBL) responsible for bacterial resistance to β-lactam antibiotics. Acinetobacter junii was previously shown possess MBL phenotype; however, the genes this phenotype were not identified. In study, we reported identification NDM-1 gene in clinical isolate A. from child patient China, which resistant all β-lactams except aztreonam but sensitive aminoglycosides and quinolones. The cloned contained an open reading...
Abstract Background Invasive group B Streptococcus (GBS) disease in Chinese infants has gradually gained attention recent years, but the molecular epidemiology of pathogen is still not well known. Methods This multicenter study retrospectively investigated distribution capsular serotypes, sequence types (STs), and hypervirulent GBS adhesin gene ( hvgA ) clinical isolates that caused invasive aged < 3 months age southern mainland China between January 2013 June 2016. Genes for antibiotic...
Purpose Salmonella infection is a key global public health concern and has lead to an increased economic burden on society. We investigated the epidemiological characteristics antimicrobial resistance profiles of clinically isolated strains in Guangzhou Women Children's Medical Center. Patients methods This was retrospective study 1,338 collected from children Center during 2016 2021. Results The results revealed that cases were mainly feces blood samples. age distribution dominated by...
The plasmid-mediated quinolone resistance qnr genes in clinical isolates adults have been described different countries; however, the frequency of their occurrence has not detected pediatric patients. A total 410 Klebsiella pneumoniae, identified as producers an extended-spectrum β-lactamase (ESBL), or AmpC β-lactamase, were collected from five children's hospitals China during 2005–2006. screened for presence qnrA, qnrB, and qnrS genes, then harboring gene a bla coding TEM, SHV, CTX-M, ampC...
A multidrug-resistant (MDR) RR2 gene cluster was identified by whole-genome sequencing in several highly virulent (ST-17) Group B streptococcus (GBS) isolates, which caused neonatal invasive infections southern China 2016. Tracing the transmission and distribution of MDR isolates this area is important for effective management future infections. The aim study to obtain longitudinal data monitor epidemiological trends general common China, provide evidence characterization antimicrobial...
Carbapenem-resistant Enterobacteriaceae (CRE) are spreading worldwide, posing a serious public health concern. However, the data on CRE strains that cause infections in children Guangzhou remain limited. Therefore, this study aimed to investigate epidemiology of CRE, drug resistance, and resistance mechanisms Guangzhou, Southern China.In total, 54 nonrepetitive were collected pediatric patients at three centers China, from January 2016 August 2018. isolates used for further studies...
Kawasaki disease is a kind of systemic vasculitis that mainly damages moderate and small-sized blood vessels, leading cause coronary artery lesions (CAL). Antiplatelet therapy routine component treatment strategies. So it important to evaluate the antiplatelet effect aspirin because individual biological variability aspirin. The immature platelet fraction (IPF) has attracted particular attention as may influence This study investigated prognostic factors for evaluating degree in children...
Maternal vaginal/rectal colonization of group B streptococcus (GBS) is a main risk for neonatal invasive infection. Efficient determination GBS in pregnant women crucial. This study aimed to investigate the prevalence carriage and evaluate diagnostic performance six methodologies screening conducted China, including blood agar plate, liquid chromogenic medium, loop-mediated isothermal amplification (LAMP) without pre-enrichment, plate with antigen detection pre-enrichment comparison standard...
The oxacillin- and cefoxitin-susceptible mecA-positive Staphylococcus aureus is a novel "stealth" methicillin-resistant S. (MRSA) type. Here, we sequenced the whole genome of two MRSA isolates from breast abscesses in lactating woman nasal swab healthy student Guangzhou for investigating mechanism underlying its occurrence. reversion these was selected by exposure to sub-MICs cefoxitin with or without mupirocin. mecA expression both parental strains their revertants determined, sequenced....
Abstract Objective To evaluate the application value of time to positivity (TTP) for blood culture combined with inflammatory parameters that included immature granulocyte percentage (IG%), count (IG#), C‐reactive protein (CRP), white cells (WBC) neutrophil (NE%), and neutrophil‐to‐lymphocyte ratio (NLR), identify bloodstream infections from contamination coagulase‐negative staphylococci (CoNS) in pediatric patients. Methods Data 12 897 inpatients CoNS were retrospectively collected analyzed...
This prospective, three-centre study tested for antimicrobial susceptibility in 898 isolates of Haemophilus influenzae between 2000 and 2002 Chinese children aged under 5 years with acute upper respiratory tract infection. The average incidence β-lactamase production was 12.0%. Overall, 88.0% were susceptible to ampicillin, 100.0% amoxicillin/clavulanic acid, ceftriaxone, cefuroxime azithromycin, 99.0% ciprofloxacin. Isolates from Beijing Shanghai had a lower tetracycline (57.0% 61.0%,...
Fluoroquinolone (FQ)-resistant Group B Streptococcus (GBS) has been reported with considerable cross-resistance, worsening the crisis of multidrug-resistant (MDR) GBS in clinical settings. However, national epidemiological data on FQ-resistant mainland China have not well-characterized. This study aimed to determine prevalence FQ resistance among from neonatal invasive infections and maternal colonization northern southern China, investigate serotyping, multilocus sequence typing, antibiotic...
Kawasaki disease (KD) is a type of that includes the development fever lasts at least 5 days and involves clinical manifestation multicellular vasculitis. KD has become one most common pediatric cardiovascular diseases. Previous studies have reported miR-218 rs11134527 A>G associated with susceptibility to various cancer risks. However, there lack evidence regarding relationship between this polymorphism risk. The present study explored correlation risk KD. We recruited 532 patients 623...