A5100669110- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Nerve injury and regeneration
- Mesenchymal stem cell research
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Virus-based gene therapy research
- Peroxisome Proliferator-Activated Receptors
- Stress Responses and Cortisol
- CAR-T cell therapy research
- Infectious Encephalopathies and Encephalitis
- Tryptophan and brain disorders
- Barrier Structure and Function Studies
- Lipid Membrane Structure and Behavior
- Sphingolipid Metabolism and Signaling
- Pharmacogenetics and Drug Metabolism
- Microbial Natural Products and Biosynthesis
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- S100 Proteins and Annexins
- Biomarkers in Disease Mechanisms
- Autophagy in Disease and Therapy
- Neurosurgical Procedures and Complications
West China Medical Center of Sichuan University
2020-2025
Sichuan University
2020-2025
West China Hospital of Sichuan University
2023-2025
State Key Laboratory of Biotherapy
2021-2023
Chengdu Center for Disease Control and Prevention
2021-2022
Chinese Academy of Sciences
2013-2021
Institute of Botany
2021
University of Chinese Academy of Sciences
2021
Army Medical University
2016-2020
Southwest Hospital
2016-2020
Abstract Although implantation of biomaterials carrying mesenchymal stem cells (MSCs) is considered as a promising strategy for ameliorating neural function after spinal cord injury (SCI), there are still some challenges including poor cell survival rate, tumorigenicity and ethics concerns. The performance the secretome derived from MSCs was more stable, its clinical transformation operable. Cytokine antibody array demonstrated that contained 79 proteins among 174 analyzed. Three-dimensional...
Neural stem/progenitor cells (NSPCs) are an important source of for cell replacement therapy after nerve injury. How to induce NSPCs differentiation towards neurons and oligodendrocytes is a challenging issue in neuroscience research. In the present study, we polarized microglia into M1 M2 phenotype, used their supernatants differentiation, investigated effects different phenotypes on mechanisms. We discovered that, exposure phenotype supernatant, differentiated fewer Tuj-1+ Olig2+ cells,...
Viscoelasticity, a time-scale mechanical feature of the native extracellular matrix (ECM), is reported to play crucial roles in plentiful cellular behaviors, whereas its effects on neuronal behavior and underlying molecular mechanism still remain obscure. Challenges are faced biocompatible synthesis neural ECM-mimicked scaffolds solely controlled with viscoelasticity due lack suitable models for neurons–viscoelastic interaction. Herein, we report difunctional hyaluronan–collagen hydrogels...
Necroptosis is widespread in neurodegenerative diseases. Here, we examined necroptosis the hippocampus and cortex after hydrocephalus found that a pathway inhibitor alleviates provides neuroprotective effects.Hydrocephalus was induced C57BL/6 mice by kaolin. Haematoxylin eosin (HE), Nissl, PI Fluoro-Jade B (FJB) staining were used for general observations. Phosphorylated receptor-interacting protein kinase 3 (p-RIP3) phosphorylated mixed lineage domain-like (p-MLKL) measured Western blotting...
The secretome secreted by stem cells and bioactive material has emerged as a promising therapeutic choice for traumatic brain injury (TBI). We aimed to determine the effect of 3D-printed collagen/chitosan/secretome derived from human umbilical cord blood mesenchymal scaffolds (3D-CC-ST) on injured tissue regeneration process. 3D-CC-ST was performed using 3D printing technology at low temperature (-20°C), physical properties degeneration rate were measured. utilization contributed higher...
Favipiravir, the first RNA polymerase inhibitor approved to treat resistant influenza, has been reported be associated with central nervous system (CNS) side effects, particularly anxiety-like behavior; nevertheless, underlying mechanism remains largely unknown. In this study, we investigated effect of favipiravir on neurobehavior mice, and combined lipidomics transcriptomics analysis explore effect. behavioral tests, mice displayed behaviors after oral administration (200 mg/kg) for 7 days...
Hemorrhagic stroke has a high mortality and disability rate. Among them, intraventricular hemorrhage (IVH) is an important factor leading to adverse outcomes. IVH can induce acute obstructive hydrocephalus chronic communicating hydrocephalus. However, there are currently no effective predictive factors for the early prediction of post-hemorrhage (PHH). To assess role inflammatory indicators in predicting PHH poor prognostic outcomes patients with ventricular hemorrhage. Single center...
Posthemorrhagic hydrocephalus (PHH) is a frequent and significant complication that impacts the prognosis of patients suffering from intraventricular hemorrhage (IVH). However, underlying mechanism uncertain. Neuronal pyroptosis characterized by neuronal lysis destruction, along with release inflammatory factors. Autophagy known to inhibit inflammation, histone deacetylase-6 (HDAC6) implicated in regulation both autophagy NLRP3 inflammasome. role these proteins an IVH model has not been...
Thaxtomins, a family of phytotoxins produced by Streptomyces spp., can cause dramatic plant cell hypertrophy and seedling stunting. Thaxtomin A is the dominant form from scabies has demonstrated herbicidal action. TxtE, cytochrome P450 enzyme 87.22, catalyzes direct nitration indolyl moiety L-tryptophan to L-4-nitrotryptophan using nitric oxide, dioxygen NADPH. The crystal structure TxtE was determined at 2.1 Å resolution described in this work. clearly defined substrate access channel...
Biallelic genetic variants in N -acetylneuraminic acid synthase ( NANS ), a critical enzyme endogenous sialic biosynthesis, are clinically associated with neurodevelopmental disorders. However, the mechanism underlying neuropathological consequences has remained elusive. Here, we found that mutation resulted absence of both and protein polysialylation cortical organoids notably reduced proliferation expansion neural progenitors. dysregulated migration differentiation, disturbed synapse...
China is one of the diversity centers gymnosperms. Nearly one-fifth (195 species) gymnosperms are located in China, but 69 species threatened. To date, conservation status gymnosperms, especially threatened remains largely unknown, which seriously restricts comprehensive protection Understanding distribution pattern richness and exploring relationships between environmental factors key steps for their protection. In this study, we first constructed a database with 13 270 records. It found...
Necrostatin-1, an inhibitor of necroptosis, can effectively inhibit necrotic apoptosis in neurological diseases, which results the inhibition inflammation, endoplasmic reticulum stress, and reactive oxygen species production substantial improvement function. However, effects necrostatin-1 on intraventricular hemorrhage (IVH) remain unknown. In this study, we established a mouse model IVH by injecting autologous blood into lateral ventricle brain. We also injected one hour prior to induction....
Abstract Objective To evaluate the application value of time to positivity (TTP) for blood culture combined with inflammatory parameters that included immature granulocyte percentage (IG%), count (IG#), C‐reactive protein (CRP), white cells (WBC) neutrophil (NE%), and neutrophil‐to‐lymphocyte ratio (NLR), identify bloodstream infections from contamination coagulase‐negative staphylococci (CoNS) in pediatric patients. Methods Data 12 897 inpatients CoNS were retrospectively collected analyzed...