A5067730992- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Inflammasome and immune disorders
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Issues in Pregnancy
- Circular RNAs in diseases
- Immune Response and Inflammation
- Mechanical Circulatory Support Devices
- Autoimmune and Inflammatory Disorders Research
- Sperm and Testicular Function
- Vasculitis and related conditions
- Pregnancy and preeclampsia studies
- Weed Control and Herbicide Applications
- Insect Resistance and Genetics
- Insect Pest Control Strategies
- Cardiac Structural Anomalies and Repair
- Plant Parasitism and Resistance
- Insect-Plant Interactions and Control
- Endometrial and Cervical Cancer Treatments
- Streptococcal Infections and Treatments
- Geochemistry and Elemental Analysis
- Ovarian function and disorders
- Polyamine Metabolism and Applications
Guangzhou Medical University
2018-2025
Guangzhou Women and Children Medical Center
2022-2024
Care Resource
2024
Institute of Plant Protection
2022-2023
Purpose: Recurrent abortion(RA) is a prevalent adverse pregnancy event. Exosomes, secreted by various body fluids, are known to play role in disease diagnosis and serve as biomarkers through intercellular communication. This study aims analyze single exosomes patients with recurrent abortion identify new that may significantly contribute abortion, providing directions for its treatment. Patients Methods: A total of 244 serum were collected, including 216 varying outcomes 28 normal...
Cardiovascula disease and recurrent miscarriage have shared risk factors, some cardiovascular disease-related candidate genes been confirmed to be associated with miscarriage. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA (lncRNA) that considered susceptibility disease. However, whether lncRNA MALAT1 polymorphisms are related unclear. We genotyped three (rs591291, rs619586, rs3200401) in 284 patients 392 controls using TaqMan methods. Logistic...
Background . Kawasaki disease (KD) is a systemic form of self-limited vasculitis in children less than five years old, and the main complication coronary artery injury. However, etiology KD remains unclear. The IL-1B polymorphisms rs16944 GG rs1143627 AA their diplotype GA/GA have been associated with significantly increased risk intravenous immunoglobulin (IVIG) resistance Taiwanese population, but relationship between A/G G/A lesions (CALs) patients has not investigated. present study...
Transgenic crops producing Bacillus thuringiensis (Bt) toxins are widely planted for insect control, but their efficacy may decrease as insects evolve resistance. Understanding the genetic basis of resistance is essential developing an integrated strategy management. To understand in pink bollworm (Pectinophora gossypiella) to Bt cotton Yangtze River Valley China, we conducted F2 screening alleles associated with (Cry1Ac) protein first time. A total 145 valid single-paired lines were...
Abstract Genetics might play various roles in susceptibility to recurrent miscarriage, and previous studies suggest that some gene polymorphisms be associated with abortion breast cancer onset. Colon cancer‐associated transcript 2 ( CCAT2 ) is a novel long noncoding RNA (lncRNA) correlated multiple cancers, including cancer. However, whether lncRNA are related miscarriage unclear. We genotyped two (rs6983267 rs3843549) 248 patients 392 controls through TaqMan real‐time polymerase chain...
Abstract Chilo suppressalis is a highly destructive insect pest of rice crops. Chemical insecticides have been used as an effective method for controlling this pest. In study, we evaluated the susceptibility seven field populations C. from three regions in Hubei Province, China, to four different over period 4 years (2019–2022). Our results showed that these areas evolved low high levels resistance abamectin (Resistant Ratio, RR = 8.5–413.4). Furthermore, were susceptible chlorantraniliprole...
Abstract Kawasaki disease (KD) is an acute systemic vasculitis that most seriously complicated by coronary artery aneurysm (CAA). The polymorphisms of platelet endothelial aggregation receptor 1 ( PEAR1 ), notably rs12041331 and rs12566888 , were found to be closely related cardiac disease. However, little known regarding the connection between KD. In this study, we genotyped in 637 healthy infants 694 KD patients (74 with CAA). Subsequently, odds ratio (OR) 95% confidence interval (CI)...
Previous studies have revealed that genetic variation in genes regulate cell migration might be associated with susceptibility to recurrent spontaneous abortion. HULC regulates the of a variety cells, and polymorphisms are diseases, but their association abortion has not been reported. This study included 610 cases 817 normal controls, four SNPs were genotyped using TaqMan method. Odds ratios (ORs) 95% confidence intervals (CIs) calculated assess associations between selected Our results...
A previous family-based linkage study revealed that Kawasaki disease (KD) was associated with variations of the ATP-binding cassette subfamily C member 4 (ABCC4) gene in most European populations. However, significant differences exist among ethnic populations and Chinese subjects; therefore, whether ABCC4 variants indicate susceptibility to KD children is unclear. The purpose this research evaluate correlations between polymorphisms a Southern population. We genotyped six (rs7986087,...
Abstract Background Activated‐platelet increases the risk of thrombosis in Kawasaki disease (KD) patients with a coronary artery aneurysm (CAA). The ADP pathway is one platelet activation and aggregation pathways. P2RY12 gene encodes receptor that highly concentrated on platelets. However, few studies have reported relation to KD susceptibility or without CAA. Methods We recruited 1335 healthy controls 776 patients, including 103 CAA, selected five polymorphisms: rs9859538, rs1491974,...
Children with Kawasaki disease (KD) resistant to intravenous immunoglobulin (IVIG) have a higher incidence of coronary artery lesions (CAL). Despite the association between Purinergic receptor P2Y12 (P2RY12) polymorphism, KD genetic susceptibility, and CAL complications being proved, few studies assessed relationship P2RY12 polymorphisms IVIG resistance in patients KD. We recruited 148 611 sensitivity selected five polymorphisms: rs9859538, rs1491974, rs7637803, rs6809699, rs2046934. A...
Sperm quality can be easily influenced by living environmental and occupational factors. This study aimed to discover potential semen related factors, expand knowledge of risk factors for quality, strengthen men's awareness protecting their own fertility assist the clinicians judge patient's fertility. 465 men without obese or underweight (18.5 < BMI 28.5 kg/m2), long-term medical history drug use, were recruited between June 2020 July 2021, they are in reproductive age (25 45 years). We...
Abstract Studies have shown that many genes regulate cell migration are associated with susceptibility to recurrent miscarriage. Terminal differentiation‐induced non‐coding RNA (TINCR) regulates the and invasion of a variety tumor cells is various diseases. However, whether lncRNA TINCR polymorphism miscarriage unclear. Therefore, we investigated relationship between rs2288947 A > G abortion. We recruited 248 spontaneous abortion patients 392 healthy control subjects from Southern Chinese...
Genetic factors may play an important role in susceptibility to recurrent miscarriage. Some cardiovascular disease-related candidate genes have been shown be associated with Long noncoding RNA ANRIL has confirmed various diseases, such as disease. However, it remains unclear whether the gene polymorphism is related miscarriage susceptibility.Three polymorphisms (rs2151280, rs1063192 and rs564398) were genotyped 819 controls 610 patients through TaqMan real-time polymerase chain reaction. The...
Kawasaki disease (KD) is an acute systemic vasculitis primarily affecting infants and children. Activated platelets predispose patients to coronary artery structural lesions that may lead thrombotic cardiovascular events. To discover potential proteins underlying platelet activation in KD, we conducted a protein chip assay of 34 cytokines discovered thymic stromal lymphopoietin (TSLP) was aberrantly expressed, which remained elevated after intravenous immunoglobulin G (IVIG) treatment during...
Accumulating evidence suggests that several microRNA (miRNA) polymorphisms are closely associated with disease susceptibility or progression, such as in Kawasaki (KD). Our previous studies revealed the association of miR-149 rs2292832 T>C and miR-196a2 rs11614913 C>T KD susceptibility. The present study further focused on relationship between three miRNA (miR-149 T>C, miR-499a rs3746444 A>G) risk coronary artery aneurysm (CAA) southern Chinese patients.We evaluated 318 patients CAAs 784...
Kawasaki disease (KD) was one of the most common primary vasculitis. IVIG resistance associated with an increased risk coronary artery aneurysm. Accumulating evidences demonstrated that inflammatory gene polymorphisms might play important roles in resistance, and zinc finger proteins were closely related to immune inflammation regulation, but effect ZNF112/rs8113807 ZNF180/rs2571051 on KD patients has not been reported.A total 996 recruited, assay TaqMan-real-time polymerase chain reaction...
Kawasaki disease (KD) is an acute systemic vascular complicated by coronary artery injury. Although polymorphisms in prostaglandin-endoperoxide synthase 1 (PTGS1) are being increasingly explored cardiovascular diseases, little known regarding the connection between PTGS1 and KD risk. We evaluated 834 patients 1474 healthy controls to explore relationship (rs1330344 rs5788) Our results showed that rs1330344 CC genotype was significantly associated with risk injury children KD. In combined...
Many inflammation-related gene polymorphisms are associated with susceptibility to recurrent miscarriage. SERPINA4 is involved in inflammation and a variety of diseases, but its relevance miscarriage unclear. Therefore, this study aimed investigate the relationship between spontaneous abortion.Two were genotyped 631 patients 771 controls by TaqMan real-time polymerase chain reaction, strength each association was evaluated through 95% confidence intervals (CIs) odds ratios (ORs).The results...
Kawasaki disease (KD) is a systemic vasculitis, and the formation of coronary artery lesions(CAL) its most common sequela. Both genetic environmental factors are considered to be important in KD. Integrin α2 (ITGA2) transmembrane receptor that associated with susceptibility several diseases, but relevance KD CAL unclear.We genotyped ITGA2 rs1126643 785 patients no-CAL(NCAL) (300 CAL, 485 age- sex-matched NCAL). OR (95% CI) adjusted were used evaluate intensity association.We found...