A5065998053- Statistical Methods in Clinical Trials
- Gene expression and cancer classification
- Plant Molecular Biology Research
- Optimal Experimental Design Methods
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Plant Stress Responses and Tolerance
- Molecular Biology Techniques and Applications
- Plant Reproductive Biology
- Genetic Mapping and Diversity in Plants and Animals
- Vibrio bacteria research studies
- Legume Nitrogen Fixing Symbiosis
- Wheat and Barley Genetics and Pathology
- Plant nutrient uptake and metabolism
- Advanced Clustering Algorithms Research
- Advanced biosensing and bioanalysis techniques
- Plant-Microbe Interactions and Immunity
- Biosensors and Analytical Detection
- Polysaccharides and Plant Cell Walls
- Agricultural pest management studies
- Metabolomics and Mass Spectrometry Studies
- Advanced Causal Inference Techniques
- Advanced Statistical Process Monitoring
- Bayesian Methods and Mixture Models
- Plant Disease Resistance and Genetics
University of California, Riverside
2015-2025
Nanjing Agricultural University
2023-2024
Qingdao Institute of Bioenergy and Bioprocess Technology
2015
Chinese Academy of Sciences
2015
City Of Hope National Medical Center
2014
City of Hope
2014
Beckman Research Institute
2014
King Abdullah University of Science and Technology
2012
University of California System
2011-2012
University of California, Davis
2010
Abstract Nuclear factor Y (NF-Y) is a ubiquitous transcription composed of three distinct subunits (NF-YA, NF-YB, and NF-YC). We found that the Arabidopsis thaliana NFYA5 transcript strongly induced by drought stress in an abscisic acid (ABA)-dependent manner. Promoter:β-glucuronidase analyses showed was highly expressed vascular tissues guard cells part induction transcriptional. contains target site for miR169, which targets mRNAs cleavage or translational repression. miR169 downregulated...
Abstract Rice (Oryza sativa), a salt-sensitive species, has considerable genetic variation for salt tolerance within the cultivated gene pool. Two indica rice genotypes, FL478, recombinant inbred line derived from population developed salinity studies, and IR29, sensitive parent of population, were selected this study. We used Affymetrix genome array containing 55,515 probe sets to explore transcriptome salt-tolerant genotypes under control salinity-stressed conditions during vegetative...
Abstract Phloem-feeding pests cause extensive crop damage throughout the world, yet little is understood about how plants perceive and defend themselves from these threats. The silverleaf whitefly (SLWF; Bemisia tabaci type B) a good model for studying phloem-feeding insect-plant interactions, as SLWF nymphs wounding have long, continuous interaction with plant. Using Affymetrix ATH1 GeneChip to monitor Arabidopsis (Arabidopsis thaliana) transcriptome, 700 transcripts were found be...
Osmotic stress imposed by soil salinity and drought significantly affects plant growth development, but osmotic sensing tolerance mechanisms are not well understood. Forward genetic screens using a root-bending assay have previously identified salt overly sensitive (sos) mutants of Arabidopsis that fall into five loci, SOS1 to SOS5. These loci required for the regulation ion homeostasis or cell expansion under stress, do play major role in component drought. Here we report an additional sos...
Abstract Root architecture traits are an important component for improving water stress adaptation. However, selection aboveground under favorable environments in modern cultivars may have led to inadvertent loss of genes and novel alleles beneficial adapting with limited water. In this study, we elucidate the physiological molecular consequences introgressing alien chromosome segment (7DL) from a wild wheat relative species (Agropyron elongatum) into cultivated (Triticum aestivum). The...
Disrupted growth hormone/insulin-like factor-1 signaling (DF) and caloric restriction (CR) extend life span delay the onset of age-related diseases in rodents. In combination, these interventions additively span. To investigate molecular basis for effects, we performed genome-wide, microarray expression analysis liver from homozygous heterozygous Ames dwarf mice fed ad libitum or CR. CR DF affected a group 95 genes. Individually together, independently 212 77 genes, respectively. These...
Soil salinity limits agricultural production and is a major obstacle for feeding the growing world population. We used natural genetic variation in salt tolerance among different Arabidopsis accessions to map quantitative trait locus (QTL) abscisic acid (ABA) sensitivity during seed germination early seedling growth. A recombinant inbred population derived from Landsberg erecta (L er ; ABA sensitive) × Shakdara (Sha; resistant) was QTL mapping. High-resolution mapping cloning of this QTL,...
RNA-directed DNA methylation (RdDM) is a conserved mechanism for epigenetic silencing of transposons and other repetitive elements. We report that the rdm4 (RNA-directed Methylation4) mutation not only impairs RdDM, but also causes pleiotropic developmental defects in Arabidopsis . Both RNA polymerase II (Pol II)- Pol V-dependent transcripts are affected mutant. RDM4 encodes novel protein from yeast to humans interacts with V plants. Our results suggest functions regulation plant development...
Host-microbe interactions at the intestinal mucosal-luminal interface (MLI) are critical factors in biology of inflammatory bowel disease (IBD).To address this issue, we performed a series investigations integrating analysis bacteria and metaproteome MLI Crohn's disease, ulcerative colitis, healthy human subjects. After quantifying these variables mucosal specimens from first sample set, searched for exhibiting strong correlations with host proteins. This assessment identified small subset...
Abstract Many tip-growing cells are capable of responding to guidance cues, during which precisely steer their growth toward the source signals. Though several players in signal perception have been identified, little is known about downstream signaling that controls direction guidance. Here, using combined modeling and experimental studies, we demonstrate Arabidopsis pollen tubes regulated by network tip growth. Tip-localized exocytosis plays a key role this integrating signals with ROP1...
Circulating microRNAs (miRNAs) are potential biomarkers useful in cancer diagnosis. They have been found to be bound various carriers like proteins, lipoprotein particles, and exosomes. It is likely that only miRNAs particular carriers, but not the overall quantity, directly related development. Herein, we developed a method for rapid separation of different miRNA serum using asymmetrical flow field fractionation (AF4). Sera from two healthy individuals (control) or patients (case) were...
An arrayed host:guest fluorescence sensor system can discriminate among and classify multiple different noncanonical DNA structures by exploiting selective molecular recognition. The is highly between folds as similar native G-quadruplexes those with bulges or vacancies. host guest form heteroternary complexes strands, the acting mediator dye, modulating emission. By applying machine learning algorithms to sensing data, prediction of folding state unknown strands possible high fidelity.
Abstract The ability to identify a specific type of leukemia using minimally invasive biopsies holds great promise improve the diagnosis, treatment selection, and prognosis prediction patients. Using genome-wide methylation profiling machine learning methods, we investigated utility CpG status differentiate blood from patients with acute lymphocytic (ALL) or myelogenous (AML) normal blood. We established panel that can distinguish ALL AML as well high sensitivity specificity. then developed...
Rice and barley are both members of Poaceae (grass family) but have a marked difference in salt tolerance. The molecular mechanism underlying this was previously unexplored. This study employs comparative genomics approach to identify analogous contrasting gene expression patterns between rice barley. A hierarchical clustering identified several interesting trajectories among genotypes. There were no major conserved the two species response stress. wheat salt-stress dataset queried for...
Abstract Background High-resolution genetic maps are needed in many crops to help characterize the diversity that determines agriculturally important traits. Hybridization microarrays detect single feature polymorphisms is a powerful technique for marker discovery and genotyping because of its highly parallel nature. However, designed gene expression analysis rarely provide sufficient coverage optimal detection nucleotide polymorphisms, which limits utility species with low rates...
As a universal second messenger, calcium (Ca2+) transmits specific cellular signals via spatiotemporal signature generated from its extracellular source and internal stores. Our knowledge of the mechanisms underlying generation Ca2+ is hampered by limited tools for simultaneously monitoring dynamic levels in multiple subcellular compartments. To overcome limitation to further improve resolutions, we have assembled molecular toolset (CamelliA lines) Arabidopsis (Arabidopsis thaliana) that...
Golden Promise is a salt-tolerant spring barley closely related to Maythorpe. Salt tolerance in has been attributed single mutation at the Ari-e locus (on 5H) resulting from irradiation of accumulates lower shoot Na+ compared Maythorpe when growing under saline conditions. This study focused on elucidating genetic basis and mechanisms involved this difference.The level polymorphism between two genotypes was explored using Barley1 GeneChip for feature polymorphisms (SFPs) an oligonucleotide...