Abstract Background Nucleotide binding site-leucine rich repeat (NBS-LRR)-encoding genes comprise the largest class of plant disease resistance genes. The 149 NBS-LRR-encoding and 58 related that do not encode LRRs represent approximately 0.8% all ORFs so far annotated in Arabidopsis ecotype Col-0. Despite their prevalence genome functional importance, there was little information regarding expression these Results We analyzed patterns ~170 Col-0 using multiple analytical approaches:...

We report the results of a genome-wide analysis transcription in Arabidopsis thaliana after treatment with Pseudomonas syringae pathovar tomato. Our time course RNA-Seq experiment uses over 500 million read pairs to provide detailed characterization response infection both susceptible and resistant hosts. The set observed differentially expressed genes is consistent previous studies, confirming extending existing findings about likely play an important role defense syringae. high coverage...

Verticillium dahliae (Vd) and albo-atrum (Va) are cosmopolitan soil fungi causing very disruptive vascular diseases on a wide range of crop plants. To date, no sexual stage has been identified in either microorganism suggesting that somatic mutation is major force generating genetic diversity. Whole genome comparative analysis the recently sequenced strains VdLs.17 VaMs.102 revealed non-random insertions transposable elements (TEs) have contributed to generation four lineage-specific (LS)...

Aims This study is designed to investigate the efficacy and safety of direct-acting oral anticoagulants (DOACs) for treatment chronic portal vein thrombosis (PVT) in liver cirrhosis patients. Materials methods In a prospective cohort study, patients were divided into DOACs group (oral rivaroxaban tablets or dabigatran etexilate capsules) control (no anticoagulant treatment). Based on propensity score matching method, 40 with PVT each groups recruited this study. CT venography was used...

Abstract Background Could nutritional status serve as prognostic factors for coronavirus disease 2019 (COVID-19)? The present study evaluated the clinical and characteristics of COVID-19 patients explored relationship between risk malnutrition at admission in-hospital mortality. Methods A retrospective, observational was conducted in two hospitals Hubei, China. Confirmed cases were typed mild/moderate, severe, or critically ill. Clinical data death collected. assessed using geriatric index...

A dissection of plant defense pathways was initiated through gene expression profiling the responses a single Arabidopsis thaliana genotype to isogenic Pseudomonas syringae strains expressing one four different cloned avirulence (avr) genes. Differences in profiles elicited by resistance (R)-avr interactions were observed. role for poly(ADP-ribosyl)ation suggested initially upregulated genes encoding NUDT7 and poly(ADP-ribose) glycohydrolase multiple R-avr interactions. Gene knockout lines...

Gastric cancer (GC) is the sixth most common malignant tumor and third leading cause of cancer-related death in world. Studies have shown that TRIM protein can regulate transcription factor activity associated with many cancers. However, role TRIM11 gastric remains unclear.

Biomarkers play important roles in the diagnosis and differential of Parkinson's disease (PD). Thus, we carried out a systematic review meta-analysis evaluating diagnostic utility cerebrospinal fluid (CSF) biomarkers to distinguish PD from atypical parkinsonian syndromes (APSs) controls. Data for APS controls were extracted 123 studies that reported concentration CSF biomarkers. Comparisons presented using pooled Hedges' g. Sources heterogeneity evaluated meta-regression, subgroup...

Abstract Background High-resolution genetic maps are needed in many crops to help characterize the diversity that determines agriculturally important traits. Hybridization microarrays detect single feature polymorphisms is a powerful technique for marker discovery and genotyping because of its highly parallel nature. However, designed gene expression analysis rarely provide sufficient coverage optimal detection nucleotide polymorphisms, which limits utility species with low rates...

Abstract Objectives To evaluate the pharmacokinetic changes in lamotrigine (LTG) from prepregnancy to postpartum and assess impact of therapeutic drug monitoring (TDM) on seizure management during pregnancy a Chinese population. Methods A series women who were LTG monotherapy before conception or included this retrospective study. The clinical characteristics mothers fetuses collected. apparent clearance (AC) ratio target concentration (RTC) calculated for each trimester month. RTCs compared...

To investigate pharmacokinetic changes in newer antiepileptic drugs (AEDs) and assess seizure frequencies risk factors of increased seizures during pregnancy women with epilepsy (WWE).A total 56 pregnancies 53 WWE who received were enrolled. Data on activity types, daily dose, AEDs blood levels derived from routine clinical follow-up. Changes clearance compared between each trimester nonpregnant baseline. The ratio AED to their targets (nonpregnant baseline) concentrations (RTC) was patients...

The aim of this study was to determine the level expression Mina53 in human cholangiocarcinoma (CCA) and explore role carcinogenesis tumor progression its clinical significance CCA. Mina53, p53 Ki67 investigated by immunohistochemistry 69 surgically resected CCA tissues 21 adjacent non-cancerous tissues. correlation between clinicopathological characteristics examined. Positive observed 61 cases (88.4%) 1 case (4.8%) tissue. markedly higher than An increased significantly associated with...

MicroRNAs (miRNAs), some small non-coding RNAs that regulate gene expression at the posttranscriptional level, are always aberrantly expressed in carcinomas. In this study, we found miR-23b-3p was remarkably up-regulated human esophageal squamous cell carcinoma cells and tissues. Moreover, could induce proliferation, invasion, metastasis vitro. EBF3 identified as direct downstream target of ectogenic strongly inhibit Furthermore, it epithelial-to-mesenchymal transition progress by blocking...

Abstract Background Hydrogen/oxygen therapy contribute to ameliorate dyspnea and disease progression in patients with respiratory diseases. Therefore, we hypothesized that hydrogen/oxygen for ordinary coronavirus 2019 (COVID-19) might reduce the length of hospitalization increase hospital discharge rates. Methods This retrospective, propensity-score matched (PSM) case–control study included 180 hospitalized COVID-19 from 3 centers. After assigned 1:2 ratios by PSM, 33 received 55 oxygen this...

Myc-induced nuclear antigen (Mina53) is a protein with molecular weight of 53 kDa expression which induced by c-Myc. Increased Mina53 documented in some human carcinomas. In this study, we found markedly increased pancreatic cancer tissue specimens. This did not correlate clinicopathological characteristics, such as sex, age, and presence distant metastasis. However, there was statistically significant association histological differentiation, TNM stage, lymph node metastases. To study...

Chlorops oryzae is an important pest of rice crops. There have been frequent outbreaks this in recent years and it has become the main some regions. To elucidate molecular mechanism C. outbreaks, we estimated genetic diversity differentiation 20 geographical populations based on a dataset ISSR markers COI sequences.ISSR data revealed high level among as measured by Shannon's information index (I), Nei's gene (H), percentage polymorphic bands (PPB). The mean coefficient (Gst) was 0.0997,...

Abstract Background The purpose of this study was to investigate the differences between clinical characteristics and factors influencing liver injury in patients with Omicron subvariant BA.5.2 (Omicron BA.5.2) prototype severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods Between December 30, 2019 November 2022, 157 infected SARS-CoV-2 199 were included case-control, single-center, retrospective study. Differences subsequently analyzed. Results None reached critical state,...

In recent years, online education has been in the ascendant China’s market. Among many competitors this market, Pigai system, an intelligent English essay marking system based on big data analysis, is standing out from crowd. More and more universities, colleges, even middle schools are taking advantage of it. This paper mainly introduces reform writing teaching model by utilizing Leshan Normal University. The experiment shown that can shorten working hours for teachers, develop students’...