A5088091678- Vitamin D Research Studies
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Estrogen and related hormone effects
- Bone health and treatments
- Bone and Dental Protein Studies
- Growth Hormone and Insulin-like Growth Factors
- Osteoarthritis Treatment and Mechanisms
- Parathyroid Disorders and Treatments
- TGF-β signaling in diseases
- MicroRNA in disease regulation
- Magnesium in Health and Disease
- Cytokine Signaling Pathways and Interactions
- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Cancer, Hypoxia, and Metabolism
- Digestive system and related health
- Alkaline Phosphatase Research Studies
- Psoriasis: Treatment and Pathogenesis
- Ion channel regulation and function
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Primate Behavior and Ecology
- Connective tissue disorders research
- Inflammatory mediators and NSAID effects
Erasmus University Rotterdam
2014-2024
Erasmus MC
2015-2024
Utrecht University
1984-2019
Erasmus MC Cancer Institute
2016
Leiden University Medical Center
2012-2014
Jagiellonian University
2014
University Medical Center
2014
Pohang University of Science and Technology
2014
AGH University of Krakow
2014
Christian University of Applied Sciences
2014
Very high plasma homocysteine levels are characteristic of homocystinuria, a rare autosomal recessive disease accompanied by the early onset generalized osteoporosis. We therefore hypothesized that mildly elevated might be related to age-related osteoporotic fractures.We studied association between circulating and risk incident fracture in 2406 subjects, 55 years age or older, who participated two separate prospective, population-based studies. In Rotterdam Study, there were independent...
Osteoporosis is a common disorder with strong genetic component. One way in which the component could be expressed through polymorphism of COLIA1, gene for collagen type Iα1, bone-matrix protein.
Ca2+ ions play a fundamental role in many cellular processes, and the extracellular concentration of is kept under strict control to allow proper physiological functions take place. The kidney, small intestine, bone determine flux pool concerted fashion. Transient receptor potential (TRP) cation channel subfamily V, members 5 6 (TRPV5 TRPV6) have recently been postulated be molecular gatekeepers facilitating influx these tissues are TRP family, which mediates diverse biological effects...
Ca2+ ions play a fundamental role in many cellular processes, and the extracellular concentration of is kept under strict control to allow proper physiological functions take place. The kidney, small intestine, bone determine flux pool concerted fashion. Transient receptor potential (TRP) cation channel subfamily V, members 5 6 (TRPV5 TRPV6) have recently been postulated be molecular gatekeepers facilitating influx these tissues are TRP family, which mediates diverse biological effects...
Abstract The genetic architecture of transcript-level variation is largely unknown. determinants were characterized in a recombinant inbred line (RIL) population (n = 211) Arabidopsis thaliana using whole-genome microarray analysis and expression quantitative trait loci (eQTL) mapping transcript levels as traits (e-traits). Genetic control transcription was highly complex: one-third the quantitatively controlled transcripts/e-traits regulated by cis-eQTL, many trans-eQTL mapped to hotspots...
Abstract Motivation: Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of vesicular nomenclatures and components, online searches for EV-related publications components currently challenging. Results: We present an improved version EVpedia, a public database EVs research. This community web portal contains identification orthologous bioinformatic tools personalized function. EVpedia includes 6879 publications, 172...
Genetic variation in the tomato clade was explored by sequencing a selection of 84 accessions and related wild species representative for Lycopersicon, Arcanum, Eriopersicon, Neolycopersicon groups. We present reconstruction three new reference genomes support our comparative genome analyses. Sequence diversity commercial breeding lines appears extremely low, indicating dramatic genetic erosion crop tomatoes. This is reflected SNP count which can exceed 10 million i.e. 20 fold higher than...
Individuals with type 2 diabetes have increased fracture risk despite higher bone mineral density (BMD). Our aim was to examine the influence of glucose control on skeletal complications.Data 4,135 participants Rotterdam Study, a prospective population-based cohort, were available (mean follow-up 12.2 years). At baseline, 420 classified by (according HbA1c calculated from fructosamine), resulting in three comparison groups: adequately controlled (ACD; n = 203; <7.5%), inadequately (ICD; 217;...
Estrogens have been shown to be essential for maintaining a sufficiently high bone mineral density and ER alpha expression has demonstrated in cells. Recently, novel estrogen receptor, receptor beta (ERbeta) identified. Here we demonstrate that also ERbeta is expressed human osteoblasts, are differentially during osteoblast differentiation. mRNA increased gradually culture, resulting an average increase of 9.9+/-5.3 fold (mean+/-S.D., n=3) at day 21 (mineralization phase) as compared 6...
Abstract Objective To examine the immunologic mechanism by which 1,25‐dihydroxyvitamin D 3 (1,25[OH] 2 ) may prevent corticosteroid‐induced osteoporosis in patients with early rheumatoid arthritis (RA), a focus on T cell biology. Methods Peripheral blood mononuclear cells (PBMCs) and CD4+CD45RO+ (memory) CD4+CD45RO− (non‐memory) separated fluorescence‐activated sorting (FACS) from treatment‐naive RA were stimulated anti‐CD3/anti‐CD28 absence or presence of various concentrations 1,25(OH) ,...
Abstract Conflicting results have been reported on the association between restriction fragment length polymorphisms (RFLPs) at vitamin D receptor (VDR) gene locus (i.e., for BsmI, ApaI, and TaqI) bone mineral density (BMD). We analyzed this in a large population-based sample (n = 1782) of men women aged 55–80 years using novel direct haplotyping polymerase chain reaction (PCR) test to monitor three polymorphic sites simultaneously. The we developed demonstrated larger degree genetic...
The role of estrogens in ischemic heart disease (IHD) is uncertain. Evidence suggests that genetic variations the estrogen receptor alpha (ESR1) gene may influence IHD risk, but common sequence ESR1 unclear.To determine whether haplotype created by c.454-397T>C (PvuII) and c.454-351A>G (XbaI) polymorphisms associated with myocardial infarction (MI) risk.In 2617 men 3791 postmenopausal women from Rotterdam Study (enrollment between 1989-1993 follow-up to January 2000), a population-based,...
Age at menopause and risk of hysterectomy have strong genetic components, but the genes involved remain ill defined. We investigated whether variation estrogen receptor (ER) gene contributes to variability in onset 900 postmenopausal women, aged 55-80 yr, Rotterdam Study, a population-based cohort study The Netherlands. Gynecological information was obtained, if women reported surgical menopause, validation type indication surgery accomplished by checking medical records. ER genotypes (PP,...
Vitamin D is an important regulator of mineral homeostasis and bone metabolism. 1Alpha-hydroxylation 25-(OH)D3 to form the bioactive vitamin hormone, 1alpha,25-(OH)2D3, classically considered take place in kidney. However, 1alpha-hydroxylase has been reported at extrarenal sites. Whether a 1alpha,25-(OH)2D3 synthesizing tissue not univocal. The aim this study was investigate autocrine/paracrine function for bone. We show that expressed human osteoblasts, as well binding protein receptors...
Several factors besides bone mineral mass have been related to the risk of hip fracture. Bone quality, rate loss, and non-skeletal identified as important.1 2 High rates resorption may be associated with disruption trabecular network well an increased loss. Furthermore, immobility disability induces not followed by formation.3 Urinary pyridinium crosslinks are markers resorption. We investigated whether these were fracture also such association was attributable disability. This nested...