A5079436788- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Osteoarthritis Treatment and Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Dental Implant Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- biodegradable polymer synthesis and properties
- Silk-based biomaterials and applications
- Periodontal Regeneration and Treatments
- Additive Manufacturing and 3D Printing Technologies
- Knee injuries and reconstruction techniques
- Bone Metabolism and Diseases
- Cellular Mechanics and Interactions
- Pluripotent Stem Cells Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Ear Surgery and Otitis Media
- Pancreatic function and diabetes
- Hydrogels: synthesis, properties, applications
- Polymer Surface Interaction Studies
- Titanium Alloys Microstructure and Properties
- Nasal Surgery and Airway Studies
- Dental materials and restorations
- Wound Healing and Treatments
Maastricht University
2016-2025
University of Twente
2012-2022
Karolinska Institutet
2022
Universitat Politècnica de Catalunya
2022
Inspire
2016-2019
Leiden University
1992-2013
Ghent University
2009-2013
In-Q-Tel
2013
Aegon (Netherlands)
2011
AkzoNobel (Netherlands)
2010
Biomaterials can be endowed with biologically instructive properties by changing basic parameters such as elasticity and surface texture. However, translation from in vitro proof of concept to clinical application is largely missing. Porous calcium phosphate ceramics are used treat small bone defects but general do not induce stem cell differentiation, which essential for regenerating large defects. Here, we prepared varying physicochemical structural characteristics. Microporosity...
The combination of the high mechanical strength metals with osteoconductive properties calcium phosphates make hydroxyapatite coatings on titanium implants widely used in orthopedic surgery. However, most popular coating method, plasma spraying, exhibits some important drawbacks: inability to cover porous and incorporate biologically active agents, delamination, particle release. aim this study was elaborate a dense, strong, thick calcium‐phosphate porous‐tantalum using two‐step biomimetic...
It is increasingly recognized that material surface topography able to evoke specific cellular responses, endowing materials with instructive properties were formerly reserved for growth factors. This opens the window improve upon, in a cost-effective manner, biological performance of any used human body. Unfortunately, interplay between topographies and cell behavior complex still incompletely understood. Rational approaches search bioactive surfaces will therefore omit previously...
To engineer tissues with clinically relevant dimensions, one must overcome the challenge of rapidly creating functional blood vessels to supply cells oxygen and nutrients remove waste products. We tested hypothesis that endothelial cells, cocultured osteoprogenitor can organize into a prevascular network in vitro. When cultured spheroid coculture model human mesenchymal stem umbilical vein (HUVECs) form 3-dimensional within 10 days vitro culture. The formation was promoted by seeding 2% or...
Abstract The use of multipotent human mesenchymal stem cells (hMSCs) for tissue engineering has been a subject extensive research. donor variation in growth, differentiation and vivo bone forming ability hMSCs is bottleneck standardization therapeutic protocols. In this study, we isolated characterized from 19 independent donors, aged between 27 85 years, investigated the extent heterogeneity to which can be expanded without loosing multipotency. Dexamethasone‐induced ALP expression varied...