A5101984642- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Hearing, Cochlea, Tinnitus, Genetics
- Statistical Methods in Clinical Trials
- Ion Channels and Receptors
- Vestibular and auditory disorders
- Olfactory and Sensory Function Studies
- Genetic Mapping and Diversity in Plants and Animals
- Artificial Intelligence in Healthcare
- Advanced Causal Inference Techniques
- Cell Image Analysis Techniques
- Hearing Loss and Rehabilitation
- Metabolomics and Mass Spectrometry Studies
- Diabetic Foot Ulcer Assessment and Management
- Nicotinic Acetylcholine Receptors Study
- Computational Drug Discovery Methods
- Biomedical and Engineering Education
- Genomics, phytochemicals, and oxidative stress
- Gene expression and cancer classification
Merck & Co., Inc., Rahway, NJ, USA (United States)
2025
Decision Sciences (United States)
2022-2025
University of California, Riverside
2020
University of Eastern Finland
1997
Kuopio University Hospital
1997
Helsinki University Hospital
1997
Abstract Polygenic risk scores (PRS) have been successfully developed for the prediction of human diseases and complex traits in past years. For drug response randomized clinical trials, a common practice is to apply PRS built from disease genome-wide association study (GWAS) directly corresponding pharmacogenomics (PGx) setting. Here, we show that such an approach relies on stringent assumptions about prognostic predictive effects selected genetic variants. We propose shift PGx approaches...
Current methods of measuring disease progression neurodegenerative disorders, including Parkinson's (PD), largely rely on composite clinical rating scales, which are prone to subjective biases and lack the sensitivity detect signals in a timely manner. Digital health technology (DHT)-derived measures offer potential solutions provide objective, precise, sensitive that address these limitations. However, complexity DHT datasets derive numerous digital features were not previously possible...
<title>Abstract</title> Pharmacogenomics (PGx) studies aim to perform drug response prediction and patient stratification using genome-wide association study (GWAS) data from randomized clinical trials. Polygenic risk scores (PRS) are useful tools for PGx. By combining information across the genome, they have shown great promise in predicting disease how patients respond a particular treatment. A common practice when developing polygenic models prediction, is use GWAS summary statistics...
Polygenic risk score (PRS) has been recently developed for predicting complex traits and drug responses. It remains unknown whether multi-trait PRS (mtPRS) methods, by integrating information from multiple genetically correlated traits, can improve prediction accuracy power analysis compared with single-trait (stPRS) methods. In this paper, we first review commonly used mtPRS methods find that they do not directly model the underlying genetic correlations among which shown to be useful in...
Abstract Polygenic risk scores (PRSs) have emerged as promising tools for the prediction of human diseases and complex traits in disease genome-wide association studies (GWAS). Applying PRSs to pharmacogenomics (PGx) has begun show great potential improving patient stratification drug response prediction. However, there are unique challenges that arise when applying PGx GWAS beyond those typically encountered (e.g. Eurocentric or trans-ethnic bias). These include: (i) lack knowledge about...
In audiological "toughening" or "conditioning" phenomenon prior exposure to moderate noise reduces the extent of hearing deterioration caused by subsequent traumatic test known cause inner ear damage. "Toughening" has been demonstrated in many mammalian laboratory animals such as guinea pig and chinchilla but not rat mouse. Our aim was study occurrence this rat. Ninety-one white male Wistar rats were divided into four groups: unexposed control group (U. n = 10), only (C, 32), plus (C + T,...
Impulse noise from firearms is a common cause of acute acoustic trauma (AAT). Recently hyperbaric oxygen treatment has become available in many hospitals treating AAT. We exposed 39 Wistar rats to intense impulse 60 shots the assault rifle (162 dB SPL). After exposure 15 animals were given (HBO) by 10 cycles 90 minutes 100%) 0.25 MPa, one cycle per day. Four weeks after hearing thresholds measured with auditory brainstem response audiometry at frequencies 1.0, 2.0, 4.0, 6.0, 8.0 and 10.0...
Abstract Background Current methods of measuring disease progression neurodegenerative disorders, including Parkinson’s (PD), largely rely on composite clinical rating scales, which are prone to subjective biases and lack the sensitivity detect signals in a timely manner. Digital health technology (DHT)-derived measures offer potential solutions provide objective, precise, sensitive that address these limitations. However, complexity DHT datasets derive numerous digital features were not...
SUMMARY Menthol is widely used in tobacco products. This study compared the effects of menthol on human bronchial epithelium using submerged cultures, a VITROCELL® cloud chamber that provides air liquid interface (ALI) exposure without solvents or heating, and Cultex ALI system delivers aerosol equivalent to inhaled during vaping. In culture, significantly increased calcium influx mitochondrial reactive oxygen species (ROS) via TRPM8 receptor, responses were inhibited by antagonist. BEAS-2B...
Abstract In the era of precision medicine, many biomarkers have been discovered to be associated with drug efficacy and safety responses, which can used for patient stratification response prediction. Due small sample size limited power randomized clinical studies, meta-analysis is usually conducted aggregate all available studies maximize identifying prognostic predictive biomarkers. Since data are already aggregated, it often challenging find an independent study replicate discoveries from...