A5066861943- Asthma and respiratory diseases
- Animal Virus Infections Studies
- MicroRNA in disease regulation
- Sphingolipid Metabolism and Signaling
- Animal Disease Management and Epidemiology
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Pediatric health and respiratory diseases
- Circular RNAs in diseases
- Viral gastroenteritis research and epidemiology
- Viral Infectious Diseases and Gene Expression in Insects
- Hepatitis C virus research
- Virus-based gene therapy research
- Soil Mechanics and Vehicle Dynamics
- Liver Disease Diagnosis and Treatment
- Plant Molecular Biology Research
- Endoplasmic Reticulum Stress and Disease
- Protein Tyrosine Phosphatases
- Bacteriophages and microbial interactions
- Wound Healing and Treatments
- Immune Cell Function and Interaction
- Cellular transport and secretion
- RNA Research and Splicing
- IL-33, ST2, and ILC Pathways
- RNA Interference and Gene Delivery
Wenzhou Medical University
2012-2024
Chinese Academy of Sciences
2024
Zhejiang Cancer Hospital
2024
Genomic (Brazil)
2024
First Affiliated Hospital of Wenzhou Medical University
2024
Haier Group (China)
2021
Karolinska Institutet
2019
Gansu Agricultural University
2006-2018
Guangxi Veterinary Research Institute
2007-2017
University of Maryland, College Park
2013
Abstract Nuclear factor Y (NF-Y) is a ubiquitous transcription composed of three distinct subunits (NF-YA, NF-YB, and NF-YC). We found that the Arabidopsis thaliana NFYA5 transcript strongly induced by drought stress in an abscisic acid (ABA)-dependent manner. Promoter:β-glucuronidase analyses showed was highly expressed vascular tissues guard cells part induction transcriptional. contains target site for miR169, which targets mRNAs cleavage or translational repression. miR169 downregulated...
Engagement of Toll-like receptors (TLRs) on macrophages leads to activation the mitogen-activated protein kinases (MAPKs), which contribute innate immune responses. MAPK activity is regulated negatively by phosphatases (MKPs). MKP-1, founding member this family dual-specificity phosphatases, has been implicated in regulating lipopolysaccharide (LPS) responses, but its role TLR-mediated responses vivo not defined. Here, we show that mice deficient MKP-1 were highly susceptible endotoxic shock...
Abstract Cold stress resulting from chilling and freezing temperatures substantially reduces crop production worldwide. To identify genes critical for cold tolerance in plants, we screened Arabidopsis thaliana mutants deregulated expression of a firefly luciferase reporter gene under the control C-REPEAT BINDING FACTOR2 (CBF2) promoter (CBF2:LUC). A regulator CBF expression1 (rcf1-1) mutant that is hypersensitive to was chosen in-depth characterization. RCF1 encodes cold-inducible DEAD...
MicroRNA-34a (miR-34a), a transcriptional target of p53, is well-known tumor suppressor gene. Here, we identified Fra-1 as new miR-34a and demonstrated that inhibits expression at both protein messenger RNA levels. In addition, found p53 indirectly regulates via miR-34a-dependant manner in colon cancer cells. Overexpression strongly inhibited cell migration invasion, which can be partially rescued by forced the transcript lacking 3′-untranslated region. The matrix metalloproteinase (MMP)-1...
Colorectal cancer (CRC) is the third most frequent and second leading cause of cancer-related death worldwide. Increasing evidence indicates that deregulation long noncoding RNAs (lncRNAs) contributes to tumor initiation progression; however, little known about biological role susceptibility candidate 9 (CASC9) in CRC. Novel lncRNAs potentially involved CRC tumorigenesis were identified from datasets downloaded The Cancer LncRNome Atlas Noncoding Cancer. cell lines HCT-116, HCT-116 p53−/−,...
Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) constitute a family of 11 dual-specificity that inactivate the MAPKs by dephosphorylation. Although contribution to cell growth and death has been examined extensively, it remains unclear whether MKPs play an essential role in regulation these processes. To clarify MKP-1, we determined effects on primary fibroblasts derived from mice lacking MKP-1. Here have shown MKP-1 is critical for inactivation p38 MAPK JNK following stimulation...
Salt stress is an important environmental factor that significantly limits crop productivity worldwide. Studies on responses of plants to salt in recent years have identified novel signaling pathways and been at the forefront plant biology general. Thus far, research has focused cytoplasmic pathways. In this study, we discovered a nuclear calcium-sensing pathway critical for tolerance reference Arabidopsis. Through forward genetic screen, found nuclear-localized calcium-binding protein, RSA1...
Venous ulcers are the most common type of human chronic nonhealing wounds and stalled in a constant excessive inflammatory state. The molecular mechanisms underlying wound inflammation remain elusive. Moreover, little is known about role regulatory RNAs, such as microRNAs, pathogenesis venous ulcers. We found that both microRNA (miR)-34a miR-34c were upregulated wound-edge epidermal keratinocytes compared with normal or skin. In keratinocytes, miR-34a promoted chemokine cytokine production....
Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are escalating global health concerns. Despite their distinct clinical presentations, both disorders share intricate genetic molecular interactions. The Hippo signaling pathway plays a crucial role in regulating cell processes is implicated the pathogenesis of IBD CRC. Circular RNAs (circRNAs) have gained attention for roles various diseases, including However, comprehensive understanding specific circRNAs involved CRC, functional...
Inherited retinal degeneration (IRD), a leading cause of human blindness worldwide, is exceptionally heterogeneous with clinical heterogeneity and genetic variety. During the past decades, tremendous efforts have been made to explore complex heterogeneity, massive mutations identified in different genes underlying IRD significant advancement sequencing technology. In this study, we developed comprehensive database, 'RetinoGenetics', which contains informative knowledge about all known...
Abstract Although increasing evidence indicated that deregulation of microRNAs (miRNAs) contributed to tumor initiation and progression, but little is known about the biological role miR-340 in ovarian cancer (OC). In this study, we found expression was downregulated OC tissues compared with its normal epithelium endometrium, treatment 5-aza-2′-deoxycytidine (5-Aza-dC) or trichostatin A (TSA) increased cells. addition, ectopic inhibited cell growth metastasis vitro vivo. Four a half LIM...
Abstract The cell transition from an inflammatory phase to a subsequent proliferative is crucial for wound healing, yet the driving mechanism remains unclear. By profiling lncRNA expression changes during human skin healing and screening functions, we identify SNHG26 as pivotal regulator in keratinocyte progenitors underpinning this transition. Snhg26 -deficient mice exhibit impaired repair characterized by delayed re-epithelization accompanied exacerbated inflammation. Single-cell...
Abstract The Fra-1 transcription factor is frequently upregulated in multiple types of tumors. Here we found that promotes miR-134 expression. activates JNK and ERK by targeting SDS22, which turn induces expression leads to upregulation. In addition, augmented H2AX S139 phosphorylation activating promoted non-homologous end joining (NHEJ)-mediated DNA repair. Therefore, ectopic reduced chemosensitivity ovarian cancer cells. Furthermore, cell proliferation, migration invasion cells, enhances...
The mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is an immediate-early gene comprised of a dual-specificity domain and noncatalytic NH(2) terminus. Here, we show that the terminus MKP-1, containing cdc25 homology domains A (CH2A) B (CH2B), mediates MKP-1 nuclear targeting modulates MAPK-mediated expression. An LXXLL motif which known to mediate protein-protein interactions with nuclear-targeted hormone receptors was identified proximal CH2A MKP-1. alone this sufficient...
Hepatitis B surface antigen (HBsAg) seropositivity is an important risk factor for hepatocellular carcinoma (HCC), and HBsAg-transgenic mice have been reported to spontaneously develop HCC. The major histocompatibility complex class I-related molecules A (MICA MICB) are NKG2D ligands that play roles in tumor immune surveillance. In the present study, we found HBsAg overexpression HepG2 cells led upregulation of 133 downregulation 9 microRNAs (miRNAs). Interestingly, several HBsAg-induced...
Bats are natural reservoirs for many pathogenic viruses, and increasing evidence supports the notion that bats can also harbor group A rotaviruses (RVAs), important causative agents of diarrhea in children young animals. Currently, 8 RVA strains possessing completely novel genotype constellations or genotypes possibly originating from other mammals have been identified African Chinese bats. However, all data were mainly based on detection RNA, present only during acute infections, which does...
Abstract Ovarian cancer (OC) causes more deaths than any other gynecological cancer. Many cellular pathways have been elucidated to be associated with OC development and progression. Specifically, the insulin-like growth factor 1 receptor/insulin receptor substrate (IGF1R/IRS1) pathway participates in development. Moreover, accumulating evidence has shown that microRNA deregulation contributes tumor initiation Here, our study aimed investigate molecular functions regulatory mechanisms of...
Abstract High rate of chronic hepatitis B virus (HBV) infection and p16 promoter methylation were found in the majority hepatocellular carcinoma (HCC). To investigate potential linkage between high p 16 HBV infection, was detected with methylation‐specific polymerase chain reaction (PCR), markers examined real‐time PCR immunologic method. 5.5% patients B, 9.1% noncancerous liver, 36.6% cirrhotic liver tissue, 70.5% cancerous tissue HCC, primarily (46.7%) (90.6%) infection. In could only be...
Hepatitis B virus surface antigen (HBsAg) is an important risk factor for hepatocellular carcinoma (HCC) and downregulated during hepatocarcinogenesis. MicroRNAs (miRNAs) are frequently deregulated in HCC tissues. However, whether the deregulation of certain miRNAs has impact on HBsAg expression remains unclear. We found here that microRNA-581 (miR-581), which hepatocarcinogenesis, promoted expression. Additionally, miR-581 targeted Dicer endoplasmic reticulum degradation-enhancing...