A5051835110- Genomics and Rare Diseases
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Plant Molecular Biology Research
- Genetics and Neurodevelopmental Disorders
- Lymphoma Diagnosis and Treatment
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Autophagy in Disease and Therapy
- Chronic Myeloid Leukemia Treatments
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Hemophilia Treatment and Research
- Plant and animal studies
- Heart Rate Variability and Autonomic Control
- Phosphorus and nutrient management
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Retinal Development and Disorders
- Epigenetics and DNA Methylation
- Coal Combustion and Slurry Processing
- Anaerobic Digestion and Biogas Production
- Ophthalmology and Eye Disorders
- DNA Repair Mechanisms
- Plant nutrient uptake and metabolism
Institute of Genetics and Developmental Biology
2025
Chinese Academy of Sciences
2015-2025
Chongqing Normal University
2025
Guangxi University
2025
Guangxi University of Chinese Medicine
2025
Zhejiang University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Anhui University of Traditional Chinese Medicine
2021-2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Abstract Hyperactive ribosome biogenesis (RiboSis) fuels unrestricted cell proliferation, whereas genomic hallmarks and therapeutic targets of RiboSis in cancers remain elusive, efficient approaches to quantify activity are still limited. Here, we have established an silico approach conveniently score based on individual transcriptome data. By employing this novel RNA-seq data 14 645 samples from TCGA/GTEx dataset 917 294 single-cell expression profiles across 13 cancer types, observed the...
Epilepsy is one of the most prevalent chronic neurological disorders, afflicting about 3.5–6.5 per 1000 children and 10.8 elderly people. With intensive effort made during last two decades, numerous genes mutations have been published to be associated with disease. An organized resource integrating annotating ever-increasing genetic data will imperative acquire a global view cutting-edge in epilepsy research. Herein, we developed EpilepsyGene (http://61.152.91.49/EpilepsyGene). It contains...
Inherited retinal degeneration (IRD), a leading cause of human blindness worldwide, is exceptionally heterogeneous with clinical heterogeneity and genetic variety. During the past decades, tremendous efforts have been made to explore complex heterogeneity, massive mutations identified in different genes underlying IRD significant advancement sequencing technology. In this study, we developed comprehensive database, 'RetinoGenetics', which contains informative knowledge about all known...
Extrachromosomal circular DNA (eccDNA) regulates tumor occurrence and development. Relevant eccDNA profiles have been established for various types of cancer; however, the expression in blood patients with hepatocellular carcinoma (HCC) liver cirrhosis (LC) remain unknown. The present study aimed to investigate HCC LC. Circle-seq was used detect eccDNAs samples. Full transcript sequencing analyze RNA Geno Ontology enrichment Kyoto Encyclopedia Genes Genome pathway analyses were performed on...
Abstract The whitefly, Bemisia tabaci is a cryptic species complex in which one member, Middle East-Asia Minor 1 (MEAM1) has invaded globally. After invading large countries like Australia, China, and the USA, MEAM1 spread rapidly across each country. In contrast, our analysis of India showed very different pattern. Despite detection being contemporaneous with invasions not widely instead remains restricted to southern regions. An assessment Indian genetic diversity level equivalent that...
Genetic screening identified a suppressor of ros1-1, mutant REPRESSOR OF SILENCING1 (ROS1; encoding DNA demethylation protein). The is mutation in the gene largest subunit replication factor C (RFC1). This RFC1 reactivates unlinked 35S-NPTII transgene, which silenced ros1 and also increases expression pericentromeric Athila retrotransposons named transcriptional silent information methylation-independent manner. rfc1 more sensitive than wild type to DNA-damaging agent methylmethane...
A maize chromosome variant called abnormal 10 (Ab10) converts knobs on arms into neocentromeres, causing their preferential segregation to egg cells in a process known as meiotic drive. We previously demonstrated that the gene Kinesin driver ( Kindr ) Ab10 encodes kinesin-14 required mobilize neocentromeres made up of major tandem repeat knob180. Here we describe second gene, TR-1 kinesin Trkin ), is minor . lies 4-Mb region not syntenic with any other genome and shows extraordinary sequence...
Abstract We screened for suppressors of repressor silencing1 (ros1) using the silenced 35S promoter-neomycin phosphotransferase II (Pro35S:NPTII) gene as a marker and identified two allelic mutants, ror1-1 ror1-2 (for suppressor ros1). Map-based cloning revealed that ROR1 encodes 31-kD protein similar to DNA replication A2 (RPA2A). Mutations in reactivate Pro35S:NPTII but not RD29A promoter-luciferase ros1 mutant. methylation rDNA, centromeric DNA, promoter regions is affected by ror1....
REPRESSOR OF SILENCING 1 (ROS1) encodes a DNA demethylase that actively removes methylation. Mutation in ROS1 leads to transcriptional gene silencing of T-DNA locus contains two genes, RD29A-LUC and 35S-NPTII, originally expressed the C24 wild type. These units have different regulation mechanisms: former mechanism is dependent on small interfering RNA (siRNA)-directed methylation, but latter not. We studied by screening suppressors ros1 mutant using silenced 35S-NPTII as selection marker...
Background: Esophageal squamous cell carcinoma (ESCC), one of the leading causes cancer mortality worldwide, is a heterogeneous with diverse clinical manifestations. However, little known about epigenetic heterogeneity and its relevance for this prevalent cancer. Methods: We generated 7.56 Tb single-base resolution whole-genome bisulfite sequencing data 84 ESCC paired paraneoplastic tissues. The analysis identified inter- intratumor DNA methylation (DNAm) heterogeneity, epigenome-wide DNAm...
Dilution is considered to be a fast and easily applicable pretreatment for anaerobic digestion (AD) of chicken manure (CM), however, dilution with fresh water uneconomical because the consumption. The present investigation was targeted at evaluating feasibility process performance AD CM diluted algal digestate (AW) methane production replace tap (TW). Moreover, kinetics parameters mass flow were also comparatively analyzed. highest (104.39 mL/g volatile solid (VS)) achieved AW under...
Intratumor heterogeneity (ITH) has been shown to be inversely associated with immune infiltration in several cancers including clear cell renal carcinoma (ccRCC), but it remains unclear whether ITH is response immunotherapy (e.g. PD-1 blockade) ccRCC.We quantified using mutant-allele tumor heterogeneity, investigated the association of parameters patients ccRCC (n = 336) as well those papillary RCC (pRCC, n 280) from The Cancer Genome Atlas, and validations were conducted an independent...
<h3>Objectives</h3> Recently, several studies documented that de novo mutations (DNMs) play important roles in the aetiology of sporadic diseases. Next-generation sequencing (NGS) enables variant calling at single-base resolution on a genome-wide scale. However, accurate identification DNMs from NGS data still remains major challenge. We developed mirTrios, web server, to accurately detect and rare inherited <h3>Methods</h3> The expectation-maximisation (EM) model was adopted identify call...
Esophageal cancer (ESCA) is the seventh most frequent and deadly neoplasm. Due to lack of early diagnosis high invasion/metastasis, prognosis ESCA remains very poor. Herein, we identify skin-related signatures as deficient in invasive ESCA, which are regulated by transcription factor ZNF750. Of note, find that TRIM29 level strongly correlated with expression many genes signatures, including significantly down-regulated due hypermethylation its promoter both precancerous lesions compared...
Coronary microvascular dysfunction (CMD) is an important feature of obstructive hypertrophic cardiomyopathy (oHCM). Angiographic resistance (AMR) offers a potent means for assessing CMD. This study sought to evaluate the prognostic value CMD burden calculated by AMR among oHCM patients. We retrospectively screened all patients diagnosed with from Fuwai Hospital between January 2017 and November 2021. Off-line assessments were performed 3 major coronary vessels independent imaging core...
The post-hydrothermal liquefaction wastewater (PHWW) was obtained from a conversion process of Spirulina sp. to bio-crude oil via hydrothermal (HTL) technology that rich in organic matter and toxicant. In this study, zeolite applied overcome the inhibitions improve anaerobic digestion (AD) efficiency. Three adding ways were evaluated: PHWW pretreated with for 5 h with/without solid-liquid separation before AD added directly, order find most ideal way add zeolite. Results indicated had...
Hydrothermal liquefaction (HTL) has been studied as a promising technology for converting wet biomass into bio-crude oil and the nutrient-rich post-hydrothermal wastewater (PHWW) could be reused algae bacteria production. However, PHWW from HTL contains various types of contaminants that need to removed before reuse. Too high nutrients (nitrogen phosphorous) contents, such ammonium, are inhibitive algal growth species in anaerobic process. It is desirable reduce concentration an acceptable...