A5082455802- Advanced Radiotherapy Techniques
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Radiation Therapy and Dosimetry
- Prostate Cancer Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Colorectal Cancer Surgical Treatments
- Prostate Cancer Treatment and Research
- Radiation Dose and Imaging
- Atomic and Subatomic Physics Research
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Medical Imaging and Analysis
- Sarcoma Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Glioma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- Hormonal and reproductive studies
- Advanced Neural Network Applications
- Bone Tumor Diagnosis and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
University of California, Los Angeles
2015-2024
Anhui Medical University
2022-2024
Ruijin Hospital
2022-2024
Ministry of Education of the People's Republic of China
2024
Zhejiang University
2024
Los Angeles Medical Center
2021
University of Chinese Academy of Sciences
2020
Guizhou Provincial People's Hospital
2020
Guangxi Normal University for Nationalities
2020
Xingyi Normal University for Nationalities
2020
Magnetic resonance imaging (MRI) guidance offers multiple theoretical advantages in the context of stereotactic body radiotherapy (SBRT) for prostate cancer. However, to our knowledge, these have yet be demonstrated a randomized clinical trial.
PurposeMagnetic resonance (MR) image guidance may facilitate safe ultrahypofractionated radiation dose escalation for inoperable pancreatic ductal adenocarcinoma. We conducted a prospective study evaluating the safety of 5-fraction stereotactic MR-guided on-table adaptive therapy (SMART) locally advanced (LAPC) and borderline resectable cancer (BRPC).Methods MaterialsPatients with LAPC or BRPC were eligible this multi-institutional, single-arm, phase 2 trial after ≥3 months systemic without...
Onboard magnetic resonance imaging (MRI) guided radiotherapy is now clinically available in nine centers the world. This technology has facilitated clinical implementation of online adaptive (OART), or ability to alter daily treatment plan based on tumor and anatomical changes real-time while patient table. However, due time sensitive nature OART, a large busy clinic many potential obstacles as well patient-related safety considerations. In this work, we have described new process care...
To demonstrate the preliminary feasibility of a longitudinal diffusion magnetic resonance imaging (MRI) strategy for assessing patient response to radiotherapy at 0.35 T using an MRI-guided system (ViewRay).Six patients (three head and neck cancer, three sarcoma) who underwent fractionated were enrolled in this study. A 2D multislice spin echo single-shot planar pulse sequence was implemented on ViewRay tested phantom studies. The same used acquire data (every 2-5 fractions) six throughout...
To review and evaluate approaches to convolutional neural network (CNN) reconstruction for accelerated cardiac MR imaging in the real clinical context.Two CNN architectures, Unet residual (Resnet) were evaluated using quantitative qualitative assessment by radiologist. Four different loss functions also considered: pixel-wise (L1 L2), patch-wise structural dissimilarity (Dssim) feature-wise (perceptual loss). The networks retrospectively prospectively under-sampled data.Based on our...
In a single-institution phase II study, we evaluated the safety of 5-day dose-equivalent neoadjuvant radiotherapy (RT) regimen for high-risk primary soft tissue sarcoma.Patients received RT alone (30 Gy in five fractions) to tumor with standard margins. The endpoint was grade ≥2 late-radiation toxicity. Major wound complications, local recurrences, and distant metastases were also examined. exploratory analysis, germline biomarkers toxicity effects study on treatment utilization.Over 2...
The improved soft tissue contrast of magnetic resonance imaging (MRI) compared to computed tomography (CT) makes it a useful modality for radiotherapy treatment planning. Even when MR images are acquired planning, the standard clinical practice currently also requires CT dose calculation and x-ray-based patient positioning. This increases workloads, introduces uncertainty due required inter-modality image registrations, involves unnecessary irradiation. While would be beneficial use...
Background and purposeRadiation dose escalation may improve local control (LC) overall survival (OS) in select pancreatic ductal adenocarcinoma (PDAC) patients. We prospectively evaluated the safety efficacy of ablative stereotactic magnetic resonance (MR)-guided adaptive radiation therapy (SMART) for borderline resectable (BRPC) locally advanced pancreas cancer (LAPC). The primary endpoint acute grade ≥ 3 gastrointestinal (GI) toxicity definitely related to SMART was previously published...
The objective of this study was to explore radiomics features from longitudinal diffusion-weighted MRIs (DWIs) for pathologic treatment effect prediction in patients with localized soft tissue sarcoma (STS) undergoing hypofractionated preoperative radiotherapy (RT). Thirty STS treated RT were recruited imaging study. DWIs acquired at three time points using a 0.35 T MRI-guided system. Treatment score (TES) obtained the post-surgery pathology as surrogate outcome. Patients divided into two...
Purpose To propose and validate a respiratory motion resolved, self-gated (SG) 4D-MRI technique to assess patient-specific breathing of abdominal organs for radiation treatment planning. Methods The proposed was based on the balanced steady-state free-precession (bSSFP) 3D k-space encoding. A novel rotating cartesian (ROCK) reordering method designed which incorporates repeatedly sampled centerline as SG surrogate allows retrospective data binning into different positions amplitude...
Objective: To evaluate variations in intra- and interfractional tumour motion, the effect on internal target volume (ITV) contour accuracy, using deformable image registration of real-time two-dimensional-sagittal cine-mode MRI acquired during lung stereotactic body radiation therapy (SBRT) treatments. Methods: Five patients underwent free-breathing SBRT treatments ViewRay system, with dose prescribed to a planning (defined as 3–6 mm expansion 4DCT-ITV). Sagittal slice cine-MR images (3.5 ×...
Spatial distortion results in image deformation that can degrade accurate targeting and dose calculations MRI-guided adaptive radiotherapy. The authors present a comprehensive assessment of 0.35 T radiotherapy system's spatial using two commercially-available phantoms with regularly spaced markers. Images the integrity were acquired five clinical protocols on machine gantry positioned at various angles. Software was developed to identify localize all phantom markers template matching...
Objective: To evaluate the feasibility of on-board diffusion-weighted imaging (DWI) with an integrated low-field MRI radiotherapy system to assess responses neoadjuvant chemoradiation (NAC) in rectal cancer. Methods: A spin echo-based planar diffusion sequence on a 0.35-T was acquired over course NAC. The apparent coefficients (ADCs) from tumour regions interest (ROIs) were calculated. functional map (fDM) created showing pixelwise ADC analysis ROI treatment. Surgical pathology correlated...
Stereotactic body radiotherapy (SBRT) is becoming increasingly used in treating localized prostate cancer (PCa), with evidence showing similar toxicity and efficacy profiles when compared longer courses of definitive radiation. Magnetic resonance imaging (MRI)-guided has multiple potential advantages over standard computed tomography (CT)-guided radiotherapy, including enhanced visualization (abrogating the need for fiducials MRI fusion), identification urethra, ability to track real-time,...
255 Background: Magnetic resonance imaging (MRI) guidance offers several theoretical advantages over computed tomography (CT) in the context of stereotactic body radiotherapy (SBRT) for intact prostate cancer. Here we report results an interim analysis phase III MIRAGE trial, which directly compared MRI- and CT-guidance with a pragmatic primary endpoint acute grade ≥2 genitourinary (GU) toxicity. Methods: is single center, randomized 3 trial. Men undergoing SBRT localized cancer were...
It has been shown that magnetic resonance imaging (MRI) guidance versus computed tomography (CT) for aggressive margin-reduction (AMR) stereotactic body radiotherapy (SBRT) in prostate cancer reduces acute toxicity, but the longer-term benefits are unknown. We performed a secondary analysis of MIRAGE, phase 3 randomized clinical trial MRI-guided SBRT cancer, to determine whether AMR with MRI significantly reduced 2-yr physician-scored or patient-reported toxic effects comparison CT guidance....