A5032521404- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiation Therapy and Dosimetry
- Advanced MRI Techniques and Applications
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Radiopharmaceutical Chemistry and Applications
- Radiation Detection and Scintillator Technologies
- Lung Cancer Diagnosis and Treatment
- Nuclear Physics and Applications
- Colorectal Cancer Surgical Treatments
- MRI in cancer diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Nonmelanoma Skin Cancer Studies
- Head and Neck Cancer Studies
- Effects of Radiation Exposure
- Atomic and Subatomic Physics Research
- Cardiovascular Disease and Adiposity
- Cerebrospinal fluid and hydrocephalus
- Cardiac Imaging and Diagnostics
- Cutaneous Melanoma Detection and Management
- Breast Cancer Treatment Studies
- Management of metastatic bone disease
- Ocular Oncology and Treatments
Agostino Gemelli University Polyclinic
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Università Cattolica del Sacro Cuore
2011-2023
Catholic University of America
2023
ViewRay (United States)
2023
Fondazione Roma
2016
Italian Association for Cancer Research
2016
Ipsen (France)
2016
Novartis (Switzerland)
2016
University of the Sacred Heart
2013
The aim of this study is to investigate the role Delta Radiomics analysis in prediction one-year local control (1yLC) patients affected by locally advanced pancreatic cancer (LAPC) and treated using Magnetic Resonance guided Radiotherapy (MRgRT). A total 35 from two institutions were enrolled: 0.35 Tesla T2*/T1 MR image was acquired for each case during simulation on treatment fraction. Physical dose converted biologically effective (BED) compensate different radiotherapy schemes. performed...
Abstract Objective Cardiovascular (CV) outcome trials have shown that in patients with type 2 diabetes (T2D), treatment sodium-glucose cotransporter-2 inhibitors (SGLT-2i) reduces CV mortality and hospital admission rates for heart failure (HF). However, the mechanisms behind these benefits are not fully understood. This study was performed to investigate effects of SGLT-2i dapagliflozin on myocardial perfusion glucose metabolism T2D stable coronary artery disease (coronary stenosis ≥ 30%...
PurposeManual recontouring of targets and Organs At Risk (OARs) is a time-consuming operator-dependent task. We explored the potential Generative Adversarial Networks (GAN) to auto-segment rectum, bladder femoral heads on 0.35T MRIs accelerate online MRI-guided-Radiotherapy (MRIgRT) workflow.Methods3D planning from 60 prostate cancer patients treated with MR-Linac were collected. A 3D GAN architecture its equivalent 2D version trained, validated tested 40, 10 respectively. The volumetric...
Abstract Objective We recently demonstrated that treatment with sodium-glucose cotransporter-2 inhibitors (SGLT-2i) leads to an increase in myocardial flow reserve patients type 2 diabetes (T2D) stable coronary artery disease (CAD). The mechanism by which this occurs is, however, unclear. One of the risk factors for cardiovascular is inflammation epicardial adipose tissue (EAT). Since latter often increased patients, it could play a role microvascular dysfunction. It also well known SGLT-2i...
To prospectively investigate dynamic 13N-ammonia PET-CT for evaluating early treatment response and predicting prognosis in advanced hepatocellular carcinoma (HCC) patients who have undergone antiangiogenic therapy. Dynamic was performed 23 HCC before therapy (baseline) 18/23 after 8-10 weeks of (post-therapy). At kinetic analysis, mean, maximum, peak values K1 (mL/cm3/min) k2 (min-1) were estimated lesions non-neoplastic liver using cardiologic 15 without any diseases as normal controls....
Organs at risk (OARs) delineation is a crucial step of radiotherapy (RT) treatment planning workflow. Time-consuming and inter-observer variability are main issues in manual OAR delineation, mainly the head neck (H & N) district. Deep-learning based auto-segmentation promising strategy to improve OARs contouring departments. A comparison deep-learning-generated auto-contours (AC) with contours (MC) was performed by three expert radiation oncologists from single center.Planning computed...
Interventional radiotherapy (IRT, brachytherapy) is a highly effective treatment method for non-melanoma skin cancer (NMSC). Traditionally, the maximum depth of NMSC lesions considered eligible contact IRT was 5 mm; however, following several national surveys and recent recommendations, such cut-off, thicker than mm may be treated by IRT. The use image guidance in defining actual treating to correctly identify clinical target volume (CTV) prevent unnecessary toxicity paramount importance....
The aim of this study was to investigate the appropriate time for performing an iodine-131 post-therapy whole-body scan (TxWBS) through a qualitative and semiquantitative analysis early late scans.This evaluated pairs scans 134 patients who underwent TxWBS on third seventh day. were analyzed evaluate sites, intensity uptake, concordance or discordance between scans, relationship with risk factors, serum thyroglobulin (Tg) levels. To radioiodine kinetics in thyroid remnants metastases, 65/134...
Interventional radiotherapy (brachytherapy) has become the new therapeutic standard in management of early stages nasal vestibule tumors; fact it allows for high local control rates and low toxicity profiles. However, since more patients will receive interventional as primary treatment, is desirable to implement novel strategies reduce dose organs at risk with future aim result further lowering long-term side effects.We were able identify two different treatment volume, including...
We prospectively evaluated the regional cerebral metabolic rate of glucose (CMRglu) before and after ventricular shunt placement in idiopathic normal-pressure hydrocephalus (iNPH) patients, to investigate whether some brain regions are more involved than others; we also correlated individual variations CMRglu with clinical scale score assessment shunting.Twenty iNPH patients (12 men; mean age 73 ± 9 years) underwent F-FDG PET-CT 1 week shunting.Before shunting, values were similar right left...
Abstract Purpose Magnetic Resonance‐guided radiotherapy (MRgRT) systems allow continuous monitoring of therapy volumes during treatment delivery and personalized respiratory gating approaches. Treatment length may therefore be significantly affected by patient’s compliance breathing control. We quantitatively analyzed process time efficiency ( T E ) using data obtained from real‐world patient logs to optimize MRgRT settings. Methods Data corresponding the first 100 patients treated with a...
2-deoxy-2-fluorine-(18F)fluoro-d-glucose Positron Emission Tomography/Computed Tomography (18F-FDG-PET/CT) is widely used in oncology mainly for diagnosis and staging of various cancer types, including lung cancer, which the most common worldwide. Since histopathologic subtypes show different degree 18F-FDG uptake, to date there are some diagnostic limits uncertainties, hindering an 18F-FDG-PET-driven classification histologic cancers. On other hand, since activated macrophages, neutrophils,...
In radiation oncology, automation of treatment planning has reported the potential to improve plan quality and increase efficiency. We performed a comprehensive dosimetric evaluation new Personalized algorithm implemented in Pinnacle3 for full VMAT prostate cancer treatments.Thirteen low-risk (without lymph-nodes irradiation) 13 high-risk (with treatments were retrospectively taken from our clinical database re-optimized using two different automated engines Pinnacle system. These engines,...