A5048437639- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Medical Imaging Techniques and Applications
- Lung Cancer Research Studies
- Cardiovascular Function and Risk Factors
- Radiomics and Machine Learning in Medical Imaging
- Diabetes Treatment and Management
- Radiation Dose and Imaging
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Liver Disease and Transplantation
- COVID-19 and healthcare impacts
- Cardiovascular Disease and Adiposity
- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Peptidase Inhibition and Analysis
- Endometrial and Cervical Cancer Treatments
- Sarcoma Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- Lung Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Adrenal and Paraganglionic Tumors
- Salivary Gland Disorders and Functions
- Thyroid Disorders and Treatments
- Biochemical Analysis and Sensing Techniques
Agostino Gemelli University Polyclinic
2018-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Università Cattolica del Sacro Cuore
2011-2023
Deutsches Historisches Institut Rom
2022
Istituto Oncologico Veneto
2017
Abstract Objective Cardiovascular (CV) outcome trials have shown that in patients with type 2 diabetes (T2D), treatment sodium-glucose cotransporter-2 inhibitors (SGLT-2i) reduces CV mortality and hospital admission rates for heart failure (HF). However, the mechanisms behind these benefits are not fully understood. This study was performed to investigate effects of SGLT-2i dapagliflozin on myocardial perfusion glucose metabolism T2D stable coronary artery disease (coronary stenosis ≥ 30%...
Abstract Objective We recently demonstrated that treatment with sodium-glucose cotransporter-2 inhibitors (SGLT-2i) leads to an increase in myocardial flow reserve patients type 2 diabetes (T2D) stable coronary artery disease (CAD). The mechanism by which this occurs is, however, unclear. One of the risk factors for cardiovascular is inflammation epicardial adipose tissue (EAT). Since latter often increased patients, it could play a role microvascular dysfunction. It also well known SGLT-2i...
Abstract Purpose To correlate somatostatin receptor (SSTR) and proliferative activity profile (SSTR2, SSTR5, Ki-67) at immunohistochemistry (IHC) with SSTR-PET/CT imaging features in a retrospective series of lung neuroendocrine tumors (NET). Proliferative by Ki-67 18 F-FDG-PET/CT parameters (when available) were also correlated. Methods Among 551 patients who underwent 68 Ga-DOTA-somatostatin analogs (SSA) between July 2011 March 2020 for neoplasms, 32 confirmed diagnosis NET included. For...
Purpose The aim of this retrospective study was to determine, by dynamic acquisition, the optimal scan time 18 F-DOPA PET/CT in patients with recurrent medullary thyroid carcinoma (MTC). Methods Twenty-one suspected MTC underwent (lasting 45 minutes) followed whole-body scan. Three different intervals acquisition were evaluated: ultra-early phase (2–5 minutes), early (5–10 and late (40–45 minutes). number SUVmax all detected lesions among 3 phases compared on qualitative semiquantitative...
Sodium-glucose co-transporter-2 (SGLT-2) inhibitors have been shown to beneficial effects on various cardiovascular (CV) outcomes in patients with type 2 diabetes (T2D) primary prevention and those a high CV risk profile. However, the mechanism(s) responsible for these benefits remain elusive unexplained. The aim of DAPAHEART study will be demonstrate that treatment SGLT-2 is associated greater myocardial insulin sensitivity T2D, determine whether this improvement can attributed decrease...
Purpose: To evaluate the performance of artificial neural networks (aNN) applied to preoperative 18 F-FDG PET/CT for predicting nodal involvement in non-small-cell lung cancer (NSCLC) patients. Methods: We retrospectively analyzed data from 540 clinically resectable NSCLC patients (333 M; 67.4 ± 9 years) undergone and pulmonary resection with hilo-mediastinal lymphadenectomy. A 3-layers NN model was (dataset randomly splitted into 2/3 training 1/3 testing). Using histopathological reference...
Adrenal masses are a frequent finding in clinical practice. Many of them incidentally discovered with prevalence 4% patients undergoing abdominal anatomic imaging and require differential diagnosis. Biochemical tests, evaluating hormonal production both adrenal cortex medulla (in particular, mineralocorticoids, glucocorticoids catecholamines), have primary importance distinguishing functional or non-functional lesions. Conventional techniques, particular computerized tomography (CT) magnetic...
We report the case of a 43-year-old man with history lung carcinoid and recent detection thyroid nodules by ultrasound. The cytological analysis raised suspicion medullary carcinoma; however, calcitonin carcinoembryonic antigen levels were in reference range. Considering previous diagnosis carcinoid, patient underwent whole-body Ga-DOTATOC PET/CT. images showed focal radiopharmaceutical uptake both lobes. After thyroidectomy, histology immunohistochemistry (negative for positive chromogranin...
Abstract We report the case of a 58-year-old man with mesenteric nodule at CT performed for abdominal pain. In suspicion neoplastic disease, he underwent 18 F-FDG PET/CT that did not show abnormal uptake. The was monitored alternating and MRI. Two years after first detection, MRI revealed an increase in size, repeated metabolic evaluation, showing increased activity. neuroendocrine tumor, anatomical site, slow growth, clinical symptoms, 68 Ga-DOTATOC focal uptake, indicating high expression...
Abstract Purpose: To investigate whether the COVID-19 pandemic and national lockdown had an impact on extent of cancer disease at staging using FDG PET/CT as surrogate marker. Methods: Retrospective observational study including patients submitted to for purposes from June 1 October 31, 2020, 2021, respectively. Data regarding primary tumour, nodal (N) status number involved stations, presence distant metastases (M) were collected. Each scan was classified in limited vs advanced status....