A5107442183- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Neuroendocrine Tumor Research Advances
- Adrenal Hormones and Disorders
- Neuroblastoma Research and Treatments
- Ophthalmology and Eye Disorders
- Glioma Diagnosis and Treatment
- Crop Yield and Soil Fertility
- Lung Cancer Research Studies
- Thyroid Cancer Diagnosis and Treatment
- Migraine and Headache Studies
- Cancer, Hypoxia, and Metabolism
- Myasthenia Gravis and Thymoma
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Pancreatic and Hepatic Oncology Research
- Thyroid Disorders and Treatments
- Plant Genetic and Mutation Studies
- Chromosomal and Genetic Variations
- Genetic Mapping and Diversity in Plants and Animals
- Cerebrospinal fluid and hydrocephalus
- Regulation of Appetite and Obesity
- Agriculture, Plant Science, Crop Management
- Blood properties and coagulation
Università Cattolica del Sacro Cuore
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2025
Agostino Gemelli University Polyclinic
2015-2025
Alessandro Manzoni Hospital
2018-2024
University of Milano-Bicocca
2024
University of Florence
1979-2024
University of L'Aquila
2024
Institute for Experimental Endocrinology and Oncology
2019
Yale University
2019
Azienda Ospedaliera Sant’Antonio Abate di Gallarate
2013-2017
Traumatic brain injury (TBI) may be associated with impairment of pituitary hormone secretion, which contribute to long-term physical, cognitive, and psychological disability. We studied the occurrence risk factors dysfunction, including growth deficiency (GHD) in 50 patients (mean age 37.6 ± 2.4 years; 40 males, 20–60 10 females, 23–87 years) TBI over 5 years. Cranial or facial fractures were documented 12 patients, neurosurgery was performed 14. According Glasgow Coma Scale (GCS), 16 had...
Context: The term primary empty sella (PES) refers to a number of endocrine and/or neurological disturbances that may be caused by the herniation subarachnoid space within sella. Setting: records all patients with diagnosis between 1985 and 2002 seen at Catholic University Rome Brescia were examined retrospectively. Patients: We have observed 171 female 42 male affected PES (over 4:1 sex ratio). mean age in our subjects was 51.8 ± 2.1 yr. Mean body mass index 27.3 3.5 kg/m2. Main Outcome...
Objective To describe demographic and hormonal characteristics, comorbidities (diabetes mellitus hypertension), therapeutic procedures their effectiveness, as well predictors of morbidity mortality in a nationwide survey Italian acromegalic patients. Design Retrospective multicenter epidemiological study endorsed by the Society Endocrinology performed 24 tertiary referral centers. The mean follow-up time was 120 months. Results A total 1512 patients, 41% male, age: 45±13 years, GH: 31±37...
Recently, the cannabinoid (CB) receptor agonist anandamide (AEA) has been shown to excite perivascular terminals of primary sensory neurons via activation vanilloid receptor-1 (VR-1). To determine whether AEA stimulates central these neurons, VR-1 activation, we studied release calcitonin gene-related peptide (CGRP)- and substance P (SP)-like immunoreactivities (LI) from slices rat dorsal spinal cord. Mobilization Ca(2+) in root ganglion (DRG) culture was also studied. (0.1-10 micrometer)...
This cross-sectional study shows that high numbers of postmenopausal women with acromegaly develop vertebral fractures in relation to the activity disease. In patients active acromegaly, occur even presence normal BMD, whereas controlled are always accompanied by a pathological BMD.We studied frequency radiological cohort or acromegaly.Thirty-six acromegalic (15 and 21 disease) were evaluated for bone metabolism (serum 25-hydroxyvitamin D, PTH, bone-specific alkaline phosphatase [BSALP],...
Data on osteoporotic fractures in acromegaly are limited. An increased prevalence of radiological vertebral was already observed postmenopausal women with active acromegaly. It is unknown whether this observation may reflect a more general risk acromegaly.This cross-sectional study.The study conducted at referral centers.Subjects included 40 males (25 patients controlled disease and 15 disease) 31 control males, age gonadal status comparable the patients.Evaluation (quantitative morphometric...
Cross-sectional studies showed an elevated prevalence of vertebral fractures in acromegaly. However, no data are available on incident this clinical setting. The objective the study was to investigate incidence and risk factors patients with This a 3-year prospective study. conducted at referral centers. Eighty-eight acromegaly (33 females, 55 males; mean age 50 years, range 21–85 years) 106 control subjects, matched for sex (43 females 63 males, 33–79 years), attending outpatient bone...
Aim To gather data regarding factors predicting responsiveness to pasireotide in acromegaly. Patients and methods SSTR2a, SSTR3, SSTR5, AIP, Ki-67 the adenoma subtype were evaluated somatotroph adenomas from 39 patients treated post-operatively with somatostatin analogues (SSAs). A standardized SSTR scoring system was applied (scores 0–3). All received first-generation SSAs, 11 resistant subsequently LAR. Results None of negative or cytoplasmic-only SSTR2a expression 0–1) responsive as...
Background: The World Health Organization (WHO) and the American Joint Cancer Committee (AJCC) modified grading of pancreatic neuroendocrine neoplasms from a three-tier (WHO-AJCC 2010) to four-tier system by introducing novel category NET G3 2017). Objectives: This study aims at validating WHO-AJCC 2017 identifying most effective system. Method: A total 2,102 patients were enrolled; entry criteria were: (i) patient underwent surgery; (ii) least 2 years follow-up; (iii) observation time up...
Abstract This cross-sectional study shows that a high number of untreated adult patients with GHD develop radiological vertebral deformities. Patients undergoing GH replacement treatment showed significantly lower prevalence deformities versus treated in the presence similar BMD, as assessed by DXA. Introduction: In this study, we investigated whether and degree spinal adults growth hormone deficiency (GHD) were related to age patients, bone turnover, recombinant human (rhGH) therapy....
Somatostatin (SRIF) analogs have been employed in medical therapy of non-functioning pituitary adenomas (NFA), with contrasting results. Previous evidence showed that SRIF can exert its antiproliferative effects by reducing vascular endothelial growth factor (VEGF) secretion and action, VEGF expression may be related to tumor growth. The aim our study was clarify the possible a multireceptor ligand on cell proliferation human NFA primary cultures. We assessed receptors (SSTR1–5), vitro...
Ki-67 is a marker of proliferation activity associated with invasiveness and prognosis in human tumors.The aim the study was to evaluate index prognostic relevance group acromegalic patients who underwent transsphenoidal surgery for GH-secreting pituitary adenoma.We selected 68 consecutive referred our hospital during 5-yr period. The determined by immunohistochemistry on tissue samples obtained from each adenoma after surgery. Those were not completely cured began medical therapy...
<b><i>Background and Objective:</i></b> In 2004, the World Health Organization defined atypical pituitary adenomas as those with a Ki-67 expression >3%, an excessive p53 increased mitotic activity. As usefulness of this classification is controversial, we reviewed typical to compare clinical prognostic features. <b><i>Patients Methods:</i></b> We retrospectively 343 consecutive adenomas. Atypical represented 18.7% cases. All patients were...
It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was assess standardized incidence ratios (SIRs) different types cancer in acromegaly on a large series managed somatostatin analogs era. evaluated Italian nationwide multicenter cohort 1512 patients, 624 men and 888 women, mean age at diagnosis 45 ± 13 years, followed up for 10 years (12573 person-years) respect general population. Cancer diagnosed 124 72 women 52 men. SIRs all...
Obesity is characterized by increased leptin levels and insulin resistance, whereas blunted GH secretion paired with normal, low, or high plasma IGF-I levels. To investigate body composition in human obesity the interactions among GH-IGF-I axis, leptin, resistance [measured homeostasis model assessment (HOMA) score], we studied 15 obese females, aged 23-54 yr (mean age, 42.7 +/- 2.6), a mass index (BMI) of 44.02 1.45 kg/m(2), who underwent treatment biliopancreatic diversion (BPD), before...
In acromegaly, a discrepancy between what are defined as "normal" levels of GH and IGF-I for every given patient is observed in up to 35% subjects at diagnosis during the follow-up.The aim study was evaluate impact receptor (GHR) polymorphism on biochemical assessment treatment acromegaly prevalence discordant IGF-I.The performed an institutional referral center tertiary care hospital.We studied prospectively retrospectively 84 consecutive acromegalic patients with active disease after...
Limited information is available on the use of natalizumab (NA) in pediatric multiple sclerosis (ped-MS) patients.The purpose this study was to describe long-term effects NA a large cohort active ped-MS patients.Patients with definite were treated if previous year they had experienced at least two relapses or severe relapse incomplete recovery while immunomodulating treatment, and new magnetic resonance imaging (MRI) lesions regardless any prior treatment.The included 55 patients (mean age:...