A5075034417- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Electrolyte and hormonal disorders
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Neuroendocrine Tumor Research Advances
- Hormonal Regulation and Hypertension
- Glioma Diagnosis and Treatment
- Diet and metabolism studies
- Ion Transport and Channel Regulation
- Genetic Syndromes and Imprinting
- Parathyroid Disorders and Treatments
- Neuroblastoma Research and Treatments
- Diabetes and associated disorders
- Ion channel regulation and function
- Heart Rate Variability and Autonomic Control
- Lipid metabolism and disorders
- Cardiac and Coronary Surgery Techniques
- Hepatitis C virus research
- Blood Pressure and Hypertension Studies
- Regulation of Appetite and Obesity
- Biomedical and Chemical Research
- Pancreatic function and diabetes
- Cardiac, Anesthesia and Surgical Outcomes
- Diabetes Treatment and Management
University of Turin
2015-2025
Piedmont Reference Center for Epidemiology and Cancer Prevention
2023-2024
Institute of Nutrition, Metabolism and Diabetes
2022-2024
Istituto di Ematologia di Bologna
2024
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2017-2023
AstraZeneca (Sweden)
2018
Diabetes Australia
2017
Merck Serono (Switzerland)
2013
Boehringer Ingelheim (Germany)
2013
Data regarding the presence of a prolactin (PRL) threshold above which pituitary magnetic resonance imaging (MRI) is mandatory in patients with hyperprolactinemia (hyperPRL) are controversial and derived primarily from studies focused on female populations. Aim our study was to evaluate cohort both sexes confirmed hyperPRL, possible correlation between PRL values abnormalities.
It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was assess standardized incidence ratios (SIRs) different types cancer in acromegaly on a large series managed somatostatin analogs era. evaluated Italian nationwide multicenter cohort 1512 patients, 624 men and 888 women, mean age at diagnosis 45 ± 13 years, followed up for 10 years (12573 person-years) respect general population. Cancer diagnosed 124 72 women 52 men. SIRs all...
The acromegalic state is associated with an increase in total body water and sodium. aim of our study was to assess the hydration status patients acromegaly using bioimpedance vector analysis (BIVA), differentiating according their disease (active, medically controlled or cured) compare confidence tolerance ellipses BIVA those relation a reference healthy population. We analyzed data from 73 consecutive aged 18 years older, diagnosed undergoing regular follow-up at Division for whom...
<b><i>Introduction:</i></b> Central diabetes insipidus (CDI) is a frequent complication of pituitary surgery, but its diagnosis lacks standardized criteria. Copeptin, surrogate marker arginine vasopressin release, triggered by psycho-physical stresses such as surgery. Low postoperative copeptin could predict CDI onset. The aims this study were the validation predictor post-neurosurgical and identification optimal timing for determination....
Abstract Purpose Cabergoline (CAB) has shown to have benefic effects on the metabolism in different clinical settings but its metabolic role acromegaly disease not been studied yet. Aim of our study was evaluate impact CAB glucose and weight patients with acromegaly. Methods All undergoing continuous treatment for at least 6 months were retrospectively screened. Exclusion criteria discontinuation more than one month, change antidiabetic or other therapy acromegaly, concomitant untreated...
Abstract Purpose Copeptin efficiently predicts post-neurosurgical central diabetes insipidus (CDI) in patients with hypothalamic-pituitary lesions, but its role characterizing changes diuresis individuals acromegaly undergoing neurosurgery remains unexplored. Our study aimed to assess postoperative fluid balance and correlate them both copeptin growth hormone (GH) levels. Methods This was a secondary analysis of prospective involving 15 endoscopic endonasal resection at our University...
The glucagon stimulation test involves the peptide intramuscular or subcutaneous administration for diagnosis of hypopituitarism. To date, no data are available regarding its intranasal formulation. Our study intended to investigate role as a potential stimulus evaluation corticotropic, somatotropic, and antidiuretic axes.Non-randomized, single-blinded, cross-over including 10 healthy subjects (50% women).All participants underwent 2 days testing, placebo was administered. At baseline, every...
Abstract Context Hyponatremia is associated with increased risk of osteoporosis and fractures. The impact hyponatremia on noninvasive indices bone quality, however, unknown. Objective To evaluate whether trabecular microarchitecture, assessed noninvasively by score (TBS), altered in patients hyponatremia. Methods We conducted a cross-sectional analysis the population-based 2005-2008 cycles National Health Nutrition Examination Survey, which TBS measurement was performed. main outcome...
Acromegaly, a disease caused by GH/IGF-I hypersecretion, is associated with high mortality rate; early recognition therefore necessary to ensure successful treatment and avoid comorbidities. We have created symptom/sign scoring tool (ACROSCORE) for physicians use identify acromegaly.To compare cases of acromegaly diagnosed between 1990 2014 against control group affected non-GH-secreting pituitary tumours symptoms signs that are most discriminative acromegaly.Confirmed patients tumours.In...
Approximately 60% of acromegaly patients are not adequately controlled by first-generation somatostatin receptor ligands. This multicenter retrospective study aimed to identify the most relevant biomarkers specific for Italian population. Resistant were enrolled consecutively based on time neurosurgery, while responders collected in a 1:2 ratio. Clinical characteristics and T2-intensity MRI scans at diagnosis retrospectively re-evaluated. Histological analyses CAM5.2 granulation patterns...
Insulin tolerance test (ITT) is the of reference for diagnosis adult GH deficiency (GHD), although GHRH in combination with arginine (ARG) or secretagogues are considered equally reliable tests. Testing secretagogue alone is, anyway, a potent stimulus exploring integrity hypothalamic pathways controlling somatotropic function. We therefore aimed to determine diagnostic reliability testing ghrelin, natural secretagogue.We studied response (every 15 MIN from TO +120 MIN) acylated ghrelin...
In type 2 diabetes mellitus (T2DM), the antidiuretic system participates in adaptation to osmotic diuresis further increasing urinary osmolality by reducing electrolyte-free water clearance. Sodium glucose co-transporter inhibitors (SGLT2i) emphasize this mechanism, promoting persistent glycosuria and natriuresis, but also induce a greater reduction of interstitial fluids than traditional diuretics. The preservation homeostasis is main task and, turn, intracellular dehydration drive...
Abstract Purpose Multiple endocrine neoplasia type 1 (MEN1) is a hereditary syndrome caused by pathogenic variants in MEN1 tumor suppressor gene. Diagnosis commonly based on clinical criteria and confirmed genetic testing. The objective of the present study was to report case characterized multiple pancreatic glucagonomas, with particular concern possible predisposing defects. Methods While conducting an extensive review most recent scientific evidence unusual glucagonoma familial forms, we...
Abstract Purpose Prolactin (PRL)-secreting tumours are associated with infertility and can be reverted by dopamine agonist (DA) therapy. The suspension of DA is recommended once pregnancy established, as all DAs cross the placenta. aim study was to evaluate rate maternal-foetal complications in women treated cabergoline (CAB) or bromocriptine (BRM) for prolactinoma during gestation effect on progression. Methods This a retrospective observational involving 43 affected who became pregnant...
Acromegaly (ACRO) is a chronic rare disease caused by pathological increase in growth hormone (GH) secretion. In ACRO an increased prevalence of psychiatric disorders has been demonstrated, particular depressive disorders, associated to significant deterioration the quality life, independently from control. addition, anger feelings, often detected subjects affected disease, have not yet investigated, pituitary patients. Aim study was evaluate patients with controlled compared suffering for...