A5028772304- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Electrolyte and hormonal disorders
- Neuroendocrine Tumor Research Advances
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Glioma Diagnosis and Treatment
- Ion Transport and Channel Regulation
- Diet and metabolism studies
- Genetic Syndromes and Imprinting
- Meningioma and schwannoma management
- Ophthalmology and Eye Disorders
- Cerebrospinal fluid and hydrocephalus
- Regulation of Appetite and Obesity
- Parathyroid Disorders and Treatments
- Neuroblastoma Research and Treatments
- High Altitude and Hypoxia
- Diabetes and associated disorders
- Cancer, Hypoxia, and Metabolism
- Effects and risks of endocrine disrupting chemicals
- Childhood Cancer Survivors' Quality of Life
- Sepsis Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Ion channel regulation and function
University of Turin
2016-2025
Institute of Nutrition, Metabolism and Diabetes
2022-2024
Istituto di Ematologia di Bologna
2024
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2017-2023
Diabetes Australia
2020
Objectives: To assess the prevalence of primary aldosteronism and its association with cardiometabolic complications in patients resistant refractory hypertension. Methods: One hundred ten consecutive true hypertension [insufficient blood pressure control despite appropriate lifestyle measures treatment at least three classes antihypertensive medication, including a diuretic] without previous cardiovascular events were screened for secondary Refractory was diagnosed case uncontrolled use...
Data regarding the presence of a prolactin (PRL) threshold above which pituitary magnetic resonance imaging (MRI) is mandatory in patients with hyperprolactinemia (hyperPRL) are controversial and derived primarily from studies focused on female populations. Aim our study was to evaluate cohort both sexes confirmed hyperPRL, possible correlation between PRL values abnormalities.
<b><i>Introduction:</i></b> Central diabetes insipidus (CDI) is a frequent complication of pituitary surgery, but its diagnosis lacks standardized criteria. Copeptin, surrogate marker arginine vasopressin release, triggered by psycho-physical stresses such as surgery. Low postoperative copeptin could predict CDI onset. The aims this study were the validation predictor post-neurosurgical and identification optimal timing for determination....
Abstract Background Vertebral fractures (VFs) are a frequent complication of acromegaly, but no studies have been so far published on effectiveness antiosteoporotic drugs in this clinical setting. Objective To evaluate whether real-life practice bone active may reduce the risk VFs patients with or controlled acromegaly. Study design Retrospective, longitudinal study including 9 tertiary care endocrine units. Patients and Methods Two hundred forty-eight acromegaly (104 males; mean age 56.00 ±...
Approximately 60% of acromegaly patients are not adequately controlled by first-generation somatostatin receptor ligands. This multicenter retrospective study aimed to identify the most relevant biomarkers specific for Italian population. Resistant were enrolled consecutively based on time neurosurgery, while responders collected in a 1:2 ratio. Clinical characteristics and T2-intensity MRI scans at diagnosis retrospectively re-evaluated. Histological analyses CAM5.2 granulation patterns...
The glucagon stimulation test involves the peptide intramuscular or subcutaneous administration for diagnosis of hypopituitarism. To date, no data are available regarding its intranasal formulation. Our study intended to investigate role as a potential stimulus evaluation corticotropic, somatotropic, and antidiuretic axes.Non-randomized, single-blinded, cross-over including 10 healthy subjects (50% women).All participants underwent 2 days testing, placebo was administered. At baseline, every...
Abstract Purpose Cabergoline (CAB) has shown to have benefic effects on the metabolism in different clinical settings but its metabolic role acromegaly disease not been studied yet. Aim of our study was evaluate impact CAB glucose and weight patients with acromegaly. Methods All undergoing continuous treatment for at least 6 months were retrospectively screened. Exclusion criteria discontinuation more than one month, change antidiabetic or other therapy acromegaly, concomitant untreated...
Abstract Purpose Copeptin efficiently predicts post-neurosurgical central diabetes insipidus (CDI) in patients with hypothalamic-pituitary lesions, but its role characterizing changes diuresis individuals acromegaly undergoing neurosurgery remains unexplored. Our study aimed to assess postoperative fluid balance and correlate them both copeptin growth hormone (GH) levels. Methods This was a secondary analysis of prospective involving 15 endoscopic endonasal resection at our University...
Acromegaly, a disease caused by GH/IGF-I hypersecretion, is associated with high mortality rate; early recognition therefore necessary to ensure successful treatment and avoid comorbidities. We have created symptom/sign scoring tool (ACROSCORE) for physicians use identify acromegaly.To compare cases of acromegaly diagnosed between 1990 2014 against control group affected non-GH-secreting pituitary tumours symptoms signs that are most discriminative acromegaly.Confirmed patients tumours.In...
Abstract Context Hyponatremia is associated with increased risk of osteoporosis and fractures. The impact hyponatremia on noninvasive indices bone quality, however, unknown. Objective To evaluate whether trabecular microarchitecture, assessed noninvasively by score (TBS), altered in patients hyponatremia. Methods We conducted a cross-sectional analysis the population-based 2005-2008 cycles National Health Nutrition Examination Survey, which TBS measurement was performed. main outcome...
The acromegalic state is associated with an increase in total body water and sodium. aim of our study was to assess the hydration status patients acromegaly using bioimpedance vector analysis (BIVA), differentiating according their disease (active, medically controlled or cured) compare confidence tolerance ellipses BIVA those relation a reference healthy population. We analyzed data from 73 consecutive aged 18 years older, diagnosed undergoing regular follow-up at Division for whom...
Abstract Context The role of copeptin in assessing hyponatremic patients at emergency department (ED) admission remains debated. Objective To assess copeptin's effectiveness evaluating extracellular fluid (ECF) volume and its predictive value adults admitted to the medical ED. Design Report from IPSO-URG, a prospective cohort study with recruitment June 2018 August 2019 6-month follow-up. Setting ED single tertiary center. Patients A consecutive sample 123 hyponatremia confirmed by direct...
Insulin tolerance test (ITT) is the of reference for diagnosis adult GH deficiency (GHD), although GHRH in combination with arginine (ARG) or secretagogues are considered equally reliable tests. Testing secretagogue alone is, anyway, a potent stimulus exploring integrity hypothalamic pathways controlling somatotropic function. We therefore aimed to determine diagnostic reliability testing ghrelin, natural secretagogue.We studied response (every 15 MIN from TO +120 MIN) acylated ghrelin...
Impulse control disorders (ICDs) have been described as a side effect of dopamine agonists (DAs) in neurological well endocrine conditions. Few studies evaluated the neuropsychological DAs hyperprolactinemic patients, and these reported relationship between ICDs. Our objective was to screen for ICD symptoms individuals with DA-treated conditions.A cross-sectional analysis conducted on 132 patients pituitary treated (DA exposed), 58 no history DA exposure (non-DA exposed). Participants...