A5010775152- Thyroid Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Neuroblastoma Research and Treatments
- Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Cancer-related Molecular Pathways
- Metabolism, Diabetes, and Cancer
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Thyroid and Parathyroid Surgery
- Breast Cancer Treatment Studies
- Medical Imaging Techniques and Applications
- Cancer Genomics and Diagnostics
- Thyroid Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- BRCA gene mutations in cancer
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Brain Metastases and Treatment
- Chronic Lymphocytic Leukemia Research
- Advanced Breast Cancer Therapies
- Gastric Cancer Management and Outcomes
Istituto Oncologico Veneto
2011-2024
Institute for Chemical and Physical Processes
2023
University of Messina
2023
Istituto di Studi sul Mediterraneo (CNR - ISMed)
2012
University of Catania
1990-2010
Mario Negri Institute for Pharmacological Research
2009
Istituto Superiore di Sanità
2007
Mediterranean University
2005
Luigi Sacco Hospital
2002-2003
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2003
The growth of breast cancer cells is under the regulation hormones, factors, and their receptors. In present study, we have employed a new, sensitive, specific radioimmunoassay for direct measurement insulin receptors in surgical specimens cancers. 159 receptor content was 6.15 +/- 3.69 ng/0.1 mg protein. This value more than sixfold higher mean found both 27 normal tissues obtained at total mastectomy (0.95 + 0.68, P less 0.001) six from reduction mammoplasty (0.84 0.78, 0.001). also any...
PURPOSE Approved systemic therapies for advanced gastroenteropancreatic neuroendocrine tumors (GEP-NETs) have shown limited capacity to reduce tumor burden and no antitumor activity after progression targeted agents (TAs). We investigated the efficacy safety of lenvatinib in patients with previously treated GEP-NETs. PATIENTS AND METHODS This was a multicenter, single-arm, open-label, phase II trial two parallel cohorts (ClinicalTrials.gov identifier: NCT02678780 ) involving 21 institutions...
Abstract Obesity is a strong risk factor for cancer progression, posing obesity-related as one of the leading causes death. Nevertheless, molecular mechanisms that endow cells with metastatic properties in patients affected by obesity remain unexplored. Here, we show IL-6 and HGF, secreted tumor neighboring visceral adipose stromal (V-ASCs), expand colorectal (CR) cell compartment (CD44v6 + ), which turn secretes neurotrophins such NGF NT-3, recruits stem within mass. Visceral...
<h3>Importance</h3> Data about the optimal timing for initiation of peptide receptor radionuclide therapy (PRRT) advanced, well-differentiated enteropancreatic neuroendocrine tumors are lacking. <h3>Objective</h3> To evaluate association upfront PRRT vs chemotherapy or targeted with progression-free survival (PFS) among patients advanced who experienced disease progression after treatment somatostatin analogues (SSAs). <h3>Design, Setting, and Participants</h3> This retrospective,...
We report a PCR-based technique for detecting thyroid cancer metastases in small nodes <1.5 cm diameter by the amplification of specific transcripts TSH-receptor and thyroglobulin. A 100% correspondence with histopathological diagnosis was observed 41/46 (89%) which an adequate sample obtained at fine needle aspiration. The genetic analysis that resulted more sensitive accurate than both cytological (28% inadequate samples, 17% false negative diagnoses) thyroglobulin measurement aspirates...
abstract The clinical behavior and outcome was evaluated in 21 nonoccult differentiated thyroid carcinomas occurring Graves’ patients during the period 1982–94 compared with that of matched tumors euthyroid controls (n = 70). At surgery, disease showed distant metastases more frequently than (3/21 14.3% vs. 1/70 1.4%, P 0.0556). also a significantly higher cumulative risk recurrent/progressive or total adverse events (odd ratios 3.14 2.07, respectively) as patients. last follow-up visit,...
From 1980 to 1988 the authors examined by fine needle aspiration biopsy (FNAB) 4609 patients with solitary thyroid nodules or multinodular goiters. A total of 5605 "cold" were evaluated and classified, on basis cytologic findings, as malignant, follicular lesions (probably malignant probably benign) benign. Then compared preoperative findings postoperative histologic results in 827 from who underwent surgery. In 805 which an adequate specimen was obtained, false-negative 2.3% false-positive...
Abstract. In order to evaluate the risk of malignancy cold thyroid nodules occurring in young as compared with adult patients, we studied a consecutive series 2327 patients solitary nodule over 6-year period. None these had been previously irradiated neck or head. Fine needle aspiration and cytologic examination were carried out all and, on basis this evaluation clinical 391 selected for surgery; 109 4–20 years old 2218 older than 20 years. Malignancy was found 11 (10.1%) 112 (5.0%)...
MicroRNA (miRNA) expression is dysregulated in many human malignancies, and a growing number of studies are focused on their potential use as tumor biomarkers. To identify miRNA signature for papillary thyroid carcinomas (PTC), we investigated profiles two independent cohorts PTCs, which included major histological subtypes [classical-type (PTC‑CT), follicular-variant (PTC‑FV), tall-cell variant (PTC‑TCV)] cases with low or intermediate risk recurrence. Using TaqMan® Array Human A+B Cards...
Abstract Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. The cell subpopulation in lineage hierarchy that serves as origin for different TC histotypes unknown. Human embryonic stem cells (hESCs) with appropriate vitro stimulation undergo sequential differentiation into thyroid progenitor (TPCs-day 22), which maturate thyrocytes (day 30). Here, we create follicular cell-derived TCs all based on specific genomic alterations delivered by CRISPR-Cas9 hESC-derived TPCs....
Purpose: Adrenocortical cancer (ACC) is an aggressive tumor characterised by a high recurrence rate and poor response to treatment. This study analyses consecutive series of ACC patients evaluate the prognostic value various clinical pathological characteristics. Methods: We retrospectively evaluated 32 followed at our Medical Center from 1997 2015 age diagnosis, gender, functional status, stage type treatment with respect overall survival (OS) disease-free (DFS) as determined Kaplan–Meier...
Erythropoiesis-stimulating agents (ESAs) are often used in treatment of patients with chemotherapy-induced anemia. Many studies have demonstrated an improved hemoglobin (Hb) response when ESA is combined intravenous iron supplementation and a higher effectiveness over traditional oral formulations. A new formulation sucrosomial featuring increased bioavailability compared to formulations has recently become available could provide valid alternative those by (IV) route. Our study evaluated...