A5060949356- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Heat shock proteins research
- Hepatitis B Virus Studies
- Renal cell carcinoma treatment
- Immunotherapy and Immune Responses
- Gestational Trophoblastic Disease Studies
- Polyomavirus and related diseases
- Cancer, Hypoxia, and Metabolism
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- Endoplasmic Reticulum Stress and Disease
- Cancer Genomics and Diagnostics
- Metabolism, Diabetes, and Cancer
- Adrenal and Paraganglionic Tumors
- Sarcoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Cholangiocarcinoma and Gallbladder Cancer Studies
Fondazione IRCCS Istituto Nazionale dei Tumori
2015-2024
Creative Research Enterprises (United States)
2021
University of Milan
2016-2021
University of Milano-Bicocca
2021
Azienda Ospedaliera San Gerardo
2021
Jackson and Tull (United States)
2021
Eastern Hepatobiliary Surgery Hospital
2005
Second Military Medical University
2005
National Cancer Institute
2001
Selection criteria and benefit of liver transplantation for hepatic metastases from neuroendocrine tumors (NETs) remain uncertain. Eighty-eight consecutive patients with metastatic NETs eligible according to Milan-NET were offered transplant (n = 42) versus nontransplant options 46) depending on list dynamics, patient disposition, age. Tumor burden between groups did not differ. Transplant younger (40.5 vs. 55.5 years; p < 0.001). Long-term outcomes compared after matching made multiple Cox...
Long-term oncologic outcomes of robotic surgery remain a hotly debated topic in surgical oncology, but sparse data have been published thus far.
<h3>Importance</h3> Data about the optimal timing for initiation of peptide receptor radionuclide therapy (PRRT) advanced, well-differentiated enteropancreatic neuroendocrine tumors are lacking. <h3>Objective</h3> To evaluate association upfront PRRT vs chemotherapy or targeted with progression-free survival (PFS) among patients advanced who experienced disease progression after treatment somatostatin analogues (SSAs). <h3>Design, Setting, and Participants</h3> This retrospective,...
Pancreatic metastases from renal cell carcinoma are uncommon and their prognostic significance is not well defined. In this analysis we evaluated the outcome of patients with pancreatic treated either targeted therapies or local treatment to pancreas. Patients between 1993 2014 were identified 11 European centers. Clinical records retrospectively reviewed. Kaplan-Meier method log-rank test used evaluate progression-free survival overall survival. Cox's proportional hazard models for...
Abstract Background High-grade gastro-entero-pancreatic neoplasms (HG GEP-NENs) can be stratified according to their morphology and Ki-67 values into three prognostic classes: neuroendocrine tumors grade 3 (NETs G3), carcinomas with < 55% (NECs <55) NECs ≥ ≥55). Methods We analyzed a cohort of 49 HG GEP-NENs by targeted Next-Generation Sequencing (TrueSight Oncology 500), RNA-seq, immunohistochemistry for p53, Rb1, SSTR-2A, PD-L1. Results Frequent genomic alterations affected TP53...
Abstract Heat shock proteins (hsp) 96 play an essential role in protein metabolism and exert stimulatory activities on innate adaptive immunity. Vaccination with tumor-derived hsp96 induces CD8+ T cell-mediated tumor regressions different animal models. In this study, we show that purified from human melanoma or colon carcinoma activate tumor- Ag-specific cells vitro expand them vivo. HLA-A*0201-restricted recognizing Ags expressed (melanoma Ag recognized by cell-1 (MART-1)/melanoma A...
Introduction: The optimal treatment for small, asymptomatic, nonfunctioning pancreatic neuroendocrine neoplasms (NF-PanNEN) is still controversial. European Neuroendocrine Tumor Society (ENETS) guidelines recommend a watchful strategy asymptomatic NF-PanNEN &lt;2 cm of diameter. Several retrospective series demonstrated that non-operative management safe and feasible, but no prospective studies are available. Aim the ASPEN study to evaluate ≤2 comparing active surveillance surgery....
Extrahepatic glucose release was evaluated during the anhepatic phase of liver transplantation in 14 recipients for localized hepatocarcinoma with mild or absent cirrhosis, who received a bolus [6,6- 2 H ]glucose and l-[3- 13 C]alanine l-[1,2- C ]glutamine to measure kinetics prove whether gluconeogenesis occurred from alanine glutamine. Twelve were studied again 7 mo thereafter along seven healthy subjects. At beginning phase, plasma increased then declined by 15%/h. The right kidney...
The aim of this study was to assess safety and efficacy pancreatic duct occlusion (PDO) with neoprene-based glue in selected patients undergoing pancreatoduodenectomy (PD) at high risk postoperative fistula (POPF).PD is the reference standard approach for tumors pancreaticoduodenal region. POPF most relevant complication after PD. PDO has been proposed as an alternative anastomosis manage stump.A single-center, prospective, nonrandomized trial enrolled 100 consecutive PD cancer. Patients...
Abstract Heat shock proteins (HSPs) are involved in the activation of both adaptive and innate immune systems. Here, we report that vaccination with autologous tumor-derived HSP96 colorectal cancer patients, radically resected for liver metastases, induced a significant boost natural killer (NK) activity detected as cytokine secretion cytotoxicity presence NK-sensitive targets. Increased NK was associated raise CD3−CD56+ and/or CD3+CD56+ NK-like T cells, displaying enhanced expression NKG2D...