A5060352190- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- Sarcoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Colorectal Cancer Treatments and Studies
- Chemokine receptors and signaling
- CAR-T cell therapy research
- Gastrointestinal Tumor Research and Treatment
- Colorectal and Anal Carcinomas
- Cancer-related Molecular Pathways
- Tumors and Oncological Cases
Fondazione IRCCS Istituto Nazionale dei Tumori
2016-2025
First Affiliated Hospital of Xiamen University
2023
Weatherford College
2023
Humanitas University
2023
Huazhong University of Science and Technology
2023
The University of Texas MD Anderson Cancer Center
2021
University of Kansas Medical Center
2021
Henry Ford Health System
2021
Allegheny General Hospital
2021
McMaster University
2021
Abstract Purpose: Hyperprogression (HP), a paradoxical boost in tumor growth, was described subset of patients treated with immune checkpoint inhibitors (ICI). Neither clinicopathologic features nor biological mechanisms associated HP have been identified. Experimental Design: Among 187 non–small cell lung cancer (NSCLC) ICI at our institute, cases were identified according to clinical and radiologic criteria. Baseline histologic samples from evaluated by IHC for myeloid lymphoid markers....
Mixed adenoneuroendocrine carcinomas (MANECs) are composed of a poorly differentiated neuroendocrine carcinoma (NEC) and non-neuroendocrine (non-NEC) neoplastic epithelial component, each representing at least 30% the tumor. At present, prognostic factors for MANECs remain largely unexplored. We investigated clinical-pathologic features large multicenter series digestive system MANECs. Surgical specimens 200 MANEC candidates were centrally reviewed; diagnosis was confirmed in 160 cases....
Abstract Purpose: Immune-checkpoint inhibitors (ICI) have improved the survival of patients with non–small cell lung cancer (NSCLC). However, only a subset benefit from ICIs, and role PD-L1 as predictive biomarker is still debated. A plasma immune-related miRNA-signature classifier (MSC) was established in screening settings to identify lethal form disease early stages. In this exploratory study, we tested efficacy MSC prognostic marker advanced NSCLC treated ICIs. Experimental Design: The...
This study was undertaken to determine the frequency, and clinicopathologic genetic features, of colon cancers driven by neurotrophic receptor tyrosine kinase (NTRK) gene fusions. Of 7008 tumors screened for NTRK expression using a pan-Trk antibody, 16 (0.23%) had Trk immunoreactivity. ArcherDx assay detected TPM3-NTRK1 (n=9), LMNA-NTRK1 (n=3), TPR-NTRK1 (n=2) EML4-NTRK3 (n=1) fusion transcripts in 15 cases with sufficient RNA quality. Patients were predominantly women (median age: 63 y)....
miRNAs play a central role in the complex signaling network of cancer cells with tumor microenvironment. Little is known on origin circulating and their relationship microenvironment lung cancer. Here, we focused cellular source relative contribution different cell types to composing our risk classifier using vitro/in vivo models clinical samples. A cell‐type specific expression pattern topography several such as mir‐145 fibroblasts, mir‐126 endothelial cells, mir‐133a skeletal muscle was...
<b><i>Background:</i></b> In gastroenteropancreatic (GEP) high-grade neuroendocrine neoplasms (H-NENs), Ki-67 threshold of 55% defines three prognosis subclasses: tumor (NET) G3, carcinoma (NEC) &#x3c;55%, and NEC ≥55%. We investigated whether the molecular profiling H-NENs differs among these subcategories evaluated potential therapeutic targets, including PD-L1. <b><i>Methods:</i></b> GEP-NEN patients, we evaluated: (i) for labeling index...
The prognostic value of Toll-like receptor 3 (TLR3) is debated in cancer, differing between tumor types, methods, and cell types. We recently showed for the first time that TLR3 expression on early stage non-small-cell lung cancer (NSCLC) results associated with a good prognosis. Here, we provide experimental evidences explaining molecular reason behind TLR3's favorable role. demonstrated activation vitro induces apoptosis lines and, accordingly, caspase-3 adenocarcinoma NSCLC specimens,...
Background Epithelial to mesenchymal transition (EMT) endows cancer cells with pro-metastatic properties, which appear most effective when enter an intermediate hybrid (H) state, characterized by integrated (M) and epithelial (E) traits. The reasons for this advantage are poorly known and, especially, it is totally unexplored whether the interplay between H-cells NK could have a role. Here we characterize mechanics of non-small cell lung (NSCLC) their subset cancer-initiating (CICs),...
Abstract Background High-grade gastro-entero-pancreatic neoplasms (HG GEP-NENs) can be stratified according to their morphology and Ki-67 values into three prognostic classes: neuroendocrine tumors grade 3 (NETs G3), carcinomas with < 55% (NECs <55) NECs ≥ ≥55). Methods We analyzed a cohort of 49 HG GEP-NENs by targeted Next-Generation Sequencing (TrueSight Oncology 500), RNA-seq, immunohistochemistry for p53, Rb1, SSTR-2A, PD-L1. Results Frequent genomic alterations affected TP53...
Lung cancer is the leading cause of cancer-related deaths. Late diagnosis and inadequate therapies contribute to poor outcomes. MicroRNAs (miRNAs) are small non-coding RNAs involved in lung development. Because miRNAs simultaneously regulate several genes, they represent an interesting therapeutic approach for treatment. We have developed Coated Cationic Lipid-nanoparticles entrapping miR-660 (CCL660) intraperitoneally administered (1.5 mg/Kg) twice a week four weeks into SCID mice carrying...
WHO classification of Thoracic Tumours defines lung carcinoid tumours (LCTs) as well-differentiated neuroendocrine neoplasms (NENs) classified in low grade typical (TC) and intermediate atypical carcinoids (AC). Limited data exist concerning protein expression morphologic factors able to predict disease aggressiveness. Though Ki-67 has proved be a powerful diagnostic prognostic factor for Gastro-entero-pancreatic NENs, its role NENs is still debated. A retrospective series 370 LCT from two...
Pulmonary typical carcinoids (TCs) are uncommon, well-differentiated neuroendocrine tumors of the lung that do not exhibit necrosis and have fewer than two mitoses per 2 mm2, as defined by current World Health Organization classifications. Despite their low-grade status favorable prognostic impact, protein expression profile morphological characteristics associated with tumor progression metastatic spread remain largely unidentified. Oncocytic spindle cell histological variants acknowledged...
Despite improvements in therapies and screening strategies, lung cancer prognosis still remains dismal, especially for metastatic tumors. Cancer stem cells (CSCs) are endowed with properties such as chemoresistance, dissemination, stem-like features, that make them one of the main causes poor survival rate patients. MicroRNAs (miRNAs), small molecules regulating gene expression, have a role development progression. In particular, miR-486-5p is an onco-suppressor miRNA found to be...
Lung cancer is the most frequent cause of cancer-related death worldwide, with limited therapeutic options and rapid development drug resistance. MicroRNAs, a class small non-coding RNAs that control different physiological processes, have been associated development, as either oncomiRNAs or tumor-suppressor miRNAs. In present study we investigated interaction between mir-486-5p mir-660-5p, two independent miRNAs, to assess their possible role synergistic effect in lung treatment. Our data...
Microenvironment-related immune and inflammatory markers, when combined with established Ki-67 morphology parameters, can improve prognostic prediction in gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs). Therefore, we evaluated the value of microenvironment tumor features (MoTIFs) GEP-NENs. For this purpose, formalin-fixed paraffin-embedded tissue sections from 350 patients were profiled by immunohistochemistry for immune, inflammatory, angiogenesis, proliferation, NEN-,...
<b><i>Background:</i></b> Little information is available concerning prognostic factors for bronchopulmonary large cell neuroendocrine carcinomas (BP-LCNECs) and even less known about combined LCNECs (Co-LCNECs). We investigated whether an integrated morphological, immunohistochemical, molecular approach could be used their evaluation. <b><i>Methods:</i></b> Morphological (including features), proliferative (mitotic count/Ki-67 index),...
Lung cancer is the leading cause of cancer‐related death worldwide. Late diagnosis and metastatic dissemination contribute to its low survival rate. Since microRNA (miRNA) deregulation triggers lung carcinogenesis, miRNAs might represent an interesting therapeutic tool for management. We identified seven miRNAs, including miR‐126‐3p miR‐221‐3p, that are deregulated in tumours compared with normal tissues a series 38 non‐small‐cell patients. A negative correlation between these two was...
Immune and epithelial cells express TLR3, a receptor deputed to respond microbial signals activating the immune response. The prognostic value of TLR3 in cancer is debated no data are currently available NSCLC, for which therapeutic approaches that target system providing encouraging results. Dissecting lung microenvironment could provide new markers, especially early stage NSCLC surgery only treatment option. In this study we investigated expression on both tumor compartments I NSCLCs....