A5009250680- Metabolism, Diabetes, and Cancer
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Extracellular vesicles in disease
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- Reproductive System and Pregnancy
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Immune cells in cancer
- Immune Cell Function and Interaction
- Lung Cancer Research Studies
- MicroRNA in disease regulation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Inhalation and Respiratory Drug Delivery
- Neurological and metabolic disorders
- Metastasis and carcinoma case studies
- Cancer-related Molecular Pathways
- Cancer Diagnosis and Treatment
- Caveolin-1 and cellular processes
- Hemoglobin structure and function
- Sphingolipid Metabolism and Signaling
- Advanced Breast Cancer Therapies
- Endometriosis Research and Treatment
Fondazione IRCCS Istituto Nazionale dei Tumori
2023-2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2021-2023
Ospedale Maggiore
2021-2022
University of Massachusetts Chan Medical School
1993
Background Epithelial to mesenchymal transition (EMT) endows cancer cells with pro-metastatic properties, which appear most effective when enter an intermediate hybrid (H) state, characterized by integrated (M) and epithelial (E) traits. The reasons for this advantage are poorly known and, especially, it is totally unexplored whether the interplay between H-cells NK could have a role. Here we characterize mechanics of non-small cell lung (NSCLC) their subset cancer-initiating (CICs),...
Progesterone (P) down-regulation of uterine estradiol (E) receptor (ER) appears to be a general mechanism by which P modulates E action in the uterus. Our present studies focus on regulation ER during changeover from dominance artificial menstrual cycles rhesus monkey. Because differential cell-type response and cellular zonation primate uterus, we used immunohistochemical analysis addition biochemical assays study P. Ki-67 immunoreactivity was as an index endometrial proliferation. We...
Glioblastoma is the most aggressive primary brain malignancy in adults, with a poor prognosis of about 14 months. Recent evidence ascribed to metformin (MET), an antihyperglycemic drug, potential reduce cancer incidence and progression, but molecular mechanisms underlying these effects need be better investigated.Here, we tested efficacy MET on n = 10 glioblastoma endothelial cells (GECs), by viability proliferation tests, as MTT Live/Dead assays, apoptosis annexin V assay caspase 3/7...
Glioblastoma (GBM) is the most common primitive tumor in adult central nervous system (CNS), classified as grade IV according to WHO 2016 classification. GBM shows a poor prognosis with an average survival of approximately 15 months, representing extreme therapeutic challenge. One its distinctive and aggressive features aberrant angiogenesis, which drives neovascularization, promising candidate for molecular target therapy. Although several pre-clinical studies clinical trials have shown...
Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer development. COPD induces activation of hypoxia-induced signaling, causing remodeling surrounding microenvironmental cells also modulating the release and cargo their extracellular vesicles (EVs). We aimed to evaluate potential role circulating EVs from subjects in onset. Plasma-EVs were isolated by ultracentrifugation heavy smoker volunteers with (COPD-EVs) or without (heavy smoker-EVs, HS-EV) characterized...
Abstract Background: Platinum-based neoadjuvant chemotherapy (pb-NACT) is the primary treatment approach for locally advanced non-small cell lung cancer (LA-NSCLC), despite offering only a limited overall survival (OS) gain. Cisplatin-induced damage has been shown to activate SDF-1/CXCR4 axis in preclinical models of NSCLC, resulting recruitment subset co-expressing stemness marker CD133 and CXCR4 (SDF-1 receptor) at distant sites. These cells, known as metastasis-initiating cells (MIC),...
Abstract Epithelial-mesenchymal transition (EMT) is a crucial biological process during development which also appears to play fundamental role in the dissemination of cancer cells. It known that hybrid states (H), cells have mixed epithelial (E) and mesenchymal (M) properties, are particularly conductive metastasis but possibility seeding secondary lesions closely linked intrinsic tumor initiation potential (stemness). An overall vision taking into account both EMT spectrum stemness...