Mauro Roberto Benvenuti
A5054246036- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Congenital Diaphragmatic Hernia Studies
- COVID-19 and healthcare impacts
- Trauma Management and Diagnosis
- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Medical Imaging and Pathology Studies
- Congenital Anomalies and Fetal Surgery
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Thyroid and Parathyroid Surgery
- Respiratory Support and Mechanisms
- Gestational Trophoblastic Disease Studies
- Cancer Immunotherapy and Biomarkers
- Myofascial pain diagnosis and treatment
- Occupational and environmental lung diseases
University of Brescia
1988-2025
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2017-2023
University of Padua
2021
St. Elizabeth Healthcare
2021
Brescia University
2020
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2019
<h3>Importance</h3> There are limited data on mortality and complications rates in patients with coronavirus disease 2019 (COVID-19) who undergo surgery. <h3>Objective</h3> To evaluate early surgical outcomes of COVID-19 different subspecialties. <h3>Design, Setting, Participants</h3> This matched cohort study conducted the general, vascular thoracic surgery, orthopedic, neurosurgery units Spedali Civili Hospital (Brescia, Italy) included underwent treatment from February 23 to April 1,...
WHO classification of Thoracic Tumours defines lung carcinoid tumours (LCTs) as well-differentiated neuroendocrine neoplasms (NENs) classified in low grade typical (TC) and intermediate atypical carcinoids (AC). Limited data exist concerning protein expression morphologic factors able to predict disease aggressiveness. Though Ki-67 has proved be a powerful diagnostic prognostic factor for Gastro-entero-pancreatic NENs, its role NENs is still debated. A retrospective series 370 LCT from two...
Pulmonary typical carcinoids (TCs) are uncommon, well-differentiated neuroendocrine tumors of the lung that do not exhibit necrosis and have fewer than two mitoses per 2 mm2, as defined by current World Health Organization classifications. Despite their low-grade status favorable prognostic impact, protein expression profile morphological characteristics associated with tumor progression metastatic spread remain largely unidentified. Oncocytic spindle cell histological variants acknowledged...
<b><i>Background:</i></b> Little information is available concerning prognostic factors for bronchopulmonary large cell neuroendocrine carcinomas (BP-LCNECs) and even less known about combined LCNECs (Co-LCNECs). We investigated whether an integrated morphological, immunohistochemical, molecular approach could be used their evaluation. <b><i>Methods:</i></b> Morphological (including features), proliferative (mitotic count/Ki-67 index),...
Only few studies compared the surgical morbidity and mortality of thoracoscopic segmentectomy versus lobectomy for non-small-cell lung cancer, in particular, by relating segmental resections with corresponding anatomical lobes.We enrolled a total 7487 patients who underwent VATS (7269) or (218) from January 2014 to July 2019. A propensity score matching approach was used account potential confounding factors between 2 groups. After matching, 349 lobectomies 208 segmentectomies were included...
The potential benefit of surgery for malignant pleural mesothelioma (MPM), especially concerning pleurectomy/decortication (P/D), is unclear from the literature. aim this study was to evaluate outcome after multimodality treatment MPM involving different types P/D and analyse prognostic factors.We reviewed 314 patients affected by who were operated on in 11 Italian centres 1 January 2007 October 2014.The characteristics population male/female ratio: 3.7/1, median age at operation 67.8 years....
This study compares the uniportal with 3-portal video-assisted thoracic surgery (VATS) by examining data collected in Italian VATS Group Database. The primary end point was early postoperative pain; secondary points were intraoperative and complications, surgical time, number of dissected lymph nodes length stay.This an observational, retrospective, cohort, multicentre on 49 units. Inclusion criteria clinical stage I-II non-small-cell lung cancer, or lobectomy R0 resection. Exclusion cT3...
According to World Health Organization guidelines, atypical carcinoids (ACs) are well-differentiated lung neuroendocrine tumours with 2-10 mitoses/2 mm2 and/or foci of necrosis (usually punctate). Besides morphological criteria, no further tools in predicting AC clinical outcomes proposed. The aim this work was identify novel factors able predict disease aggressiveness and progression. METHODS AND RESULTS: Three hundred-seventy were collected centrally reviewed by two expert pathologists....
Introduction The standard of care for patients with unresectable stage III non-small cell lung cancer (NSCLC) is chemoradiotherapy (CRT) followed by consolidation durvalumab as shown in the PACIFIC trial. purpose this study to evaluate clinical outcomes and toxicities regarding use a real scenario. Methods A single-center retrospective was conducted on diagnosis NSCLC who underwent radical CRT or not durvalumab. Tumor response after CRT, pattern relapse, overall survival (OS)...
Pulmonary large cell carcinoma (LCC) is an undifferentiated neoplasm lacking morphological, histochemical, and immunohistochemical features of small lung cancer, adenocarcinoma (ADC), or squamous (SCC). The available molecular information on this rare disease limited. This study aimed to provide integrated overview 16 cases evaluating the mutational asset 409 genes transcriptomic profiles 20,815 genes. Our data showed that TP53 was most frequently inactivated gene (15/16; 93.7%) followed by...
Malignant mesothelioma is a type of cancer that affects the mesothelium. It an aggressive and deadly form often caused by exposure to asbestos. At molecular level, it characterized low number genetic mutations high heterogeneity among patients. In this work, we analyzed plasticity gene expression primary mesothelial cells comparing their properties on 2D versus 3D surfaces. First, derived from human samples four independent cells. Then, used Nichoids, which are micro-engineered substrates,...
Mediastinal goiter (MG) removal occasionally needs sternotomy, mainly in case of subaortic extension. We aimed to test the hypothesis that sternal-split may safely replace full sternotomy for MG (through total thyroidectomy) when thoracic access is required. conducted a prospective observational cohort study comparing 15 MGs receiving with 87 undergoing cervicotomy alone between January 1997 and June 2009. Among cases requiring sternal incision, was extended angle Louis nine patients (60%),...
The Italian VATS Group database was accessed to evaluate whether preoperative and intraoperative factors may affect the safety of lymphadenectomy (LA) during video-assisted thoracic surgery lobectomy.All lobectomy procedures performed between 1 January 2014 30 March 2017 for non-small-cell lung cancer with cN0 or cN1 disease were identified in database. LA evaluated based on (operative time, bleeding conversion rate) postoperative (30-day morbidity mortality, chest drain duration length...
Introduction: Poorly differentiated neuroendocrine carcinomas (NECs) are characterized by aggressive clinical course and poor prognosis. No reliable prognostic markers have been validated to date; thus, the definition of a specific NEC algorithm represents need. This study aimed analyze large case series validate factors identified in previous studies on gastro-entero-pancreatic lung NECs assess if further parameters can be isolated. Methods: A pooled analysis four retrospective was...
Combined large cell neuroendocrine carcinoma (CoLCNEC) is given by the association of LCNEC with adeno or squamous any non-neuroendocrine carcinoma. Molecular bases CoLCNEC pathogenesis are scant and no standardized therapies defined.44 CoLCNECs: 26 adenocarcinoma (CoADC), 7 (CoSQC), 3 small (CoSCLC), 4 atypical carcinoid (CoAC) napsin-A positive (NapA+), were assessed for alterations in 409 genes transcriptomic profiling 20,815 genes.Genes altered included TP53 (n = 30), RB1 14) KRAS 13)....
Background: Persistent air leak and the management of intraoperative blood loss are common threats in thoracic surgical practice. The availability new procedures, technology materials is constantly evolving topical hemostats sealants must be added to this toolkit. Topical differ according their chemical nature physical characteristics, origin mechanism action, regulatory/registration vigilance paths. A Delphi consensus was set highlight different points view on use haemostatic products among...
About 10% of cervico-mediastinal goiter need to associate cervicotomy with a total or partial sternotomy allow safe removal the goiter. Aim this study is identify preoperative predictors for mediastinal Between January 2008 and December 2015, 586 patients were submitted thyroidectomy at Surgical Clinic Brescia, Italy. Among these, have been divided in two groups based on necessity an associated operating field: Group 1 (n = 40 patients) did not 2 4 underwent sternotomy. Clinical pathological...