A5072021164- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Circular RNAs in diseases
- Colorectal Cancer Surgical Treatments
- Gallbladder and Bile Duct Disorders
- Cerebrovascular and Carotid Artery Diseases
- Metastasis and carcinoma case studies
- Liver physiology and pathology
- Liver Disease and Transplantation
- Pancreatitis Pathology and Treatment
- Organ Transplantation Techniques and Outcomes
- Esophageal and GI Pathology
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Abdominal vascular conditions and treatments
- Abdominal Surgery and Complications
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2006-2024
University of Brescia
2015-2024
Universität Hamburg
2024
University Medical Center Hamburg-Eppendorf
2024
Brescia University
2000-2022
University of Amsterdam
2022
Amsterdam University Medical Centers
2022
Kanazawa University
1990
To evaluate the predictive factors, therapy, and prognosis of intrahepatic recurrence (IR) after surgery for hepatocellular carcinoma (HCC).The factors IR are debated. class according to modality presentation may help find a correlation select right therapy recurrence.A total 213 patients were evaluated. Risk related time (<2 years >2 years) type (marginal, nodular, diffuse). Prognosis studied in each group patients.IR was observed 143 patients; 109 early (group 1) 34 late recurrences 2)....
<h3>Importance</h3> There are limited data on mortality and complications rates in patients with coronavirus disease 2019 (COVID-19) who undergo surgery. <h3>Objective</h3> To evaluate early surgical outcomes of COVID-19 different subspecialties. <h3>Design, Setting, Participants</h3> This matched cohort study conducted the general, vascular thoracic surgery, orthopedic, neurosurgery units Spedali Civili Hospital (Brescia, Italy) included underwent treatment from February 23 to April 1,...
Objective: To develop and update evidence- consensus-based guidelines on laparoscopic robotic pancreatic surgery. Summary Background Data: Minimally invasive surgery (MIPS), including surgery, is complex technically demanding. Minimizing the risk for patients requires stringent, evidence-based guidelines. Since International Miami Guidelines MIPS in 2019, new developments key publications have been reported, necessitating an update. Methods: Evidence-based 22 topics 8 domains were proposed:...
Urokinase‐type plasminogen activator (uPA) and c‐met play a major role in cancer invasion metastasis. Evidence has suggested that uPA overexpression may be coordinated human hepatocellular carcinoma (HCC). In the present study, to understand whether expression of these genes might coregulated by specific microRNAs (miRs) cells, we predicted Homo sapiens microRNA‐23b could recognize two sites 3′‐UTR four algorithm pictar . The miR‐23b analysis tumor normal cells revealed an inverse trend with...
Hepatocellular carcinoma (HCC) is the most common liver cancer and second leading cause of related death worldwide. Most HCCs occur in a damaged cirrhotic background it may be difficult to discriminate between regenerative nodules early HCCs. No dependable molecular biomarker exists for detection HCC. MicroRNAs (miRNAs) have attracted attention as potential blood-based biomarkers. To identify circulating miRNAs with diagnostic HCC, we performed preliminary RNAseq studies on plasma samples...
To reach global expert consensus on the definition of TOLS in minimally invasive and open liver resection among renowned international surgeons using a modified Delphi method.Textbook outcome is novel composite measure combining most desirable postoperative outcomes into one single representing ideal course. Despite recently developed Textbook Outcome Liver Surgery (TOLS), standardized consensus-based lacking.This international, consensus-based, qualitative study used process to achieve...
Abstract Hepatocellular carcinoma (HCC) is one of most malignant and aggressive human tumors. Transforming growth factor-β1 (TGF-β1) its coreceptor CD105 have been shown to contribute HCC progression. TGF-β1 also implicated in angiogenesis, but their role the vascularization has not investigated. To fill this gap, we studied effect on HCC-derived endothelium. By using immunomagnetic beads, isolated cultured endothelial cells (ECs) from (HCC-EC) adjacent nonneoplastic tissue (nNL-ECs)...
Abstract Background Hepatocellular carcinoma (HCC) is a challenging malignancy of global importance, it the third most common cause cancer-related mortality worldwide. In last years multikinase inhibitor sorafenib has been used for advanced HCC, but some patients do not benefit from this therapy; thus, novel therapeutic options based on molecular approaches are urgently needed. microRNAs short non coding RNAs involved in several physiological and pathological conditions including HCC...
BACKGROUNDMediastinal leakage (ML) is one of the most feared complications esophagectomy.A standard strategy for its diagnosis and treatment has been
Abstract Background This study compared patients undergoing colorectal cancer surgery in 20 hospitals of northern Italy 2019 versus 2020, order to evaluate whether COVID-19-related delays screening resulted more advanced cancers at diagnosis and worse clinical outcomes. Method was a retrospective multicentre cohort analysis March December 2020. Independent predictors disease stage (oncological stage, associated symptoms, T4 metastasis) outcome (surgical complications, palliative surgery,...
Hepatocyte growth factor/scatter factor (HGF/SF) is one of the most important humoral mediators liver regeneration. It potentially related to molecular mechanisms hepatocarcinogenesis via a paracrine system involving its cellular receptor, c-met. In this study, expression patterns HGF and c-met were evidenced by multiplex RT-PCR in different specimens human hepatic tissues (n = 71). A significant increase mRNA was detected hepatitis (P 0.001), cirrhosis 0.006), hepatocellular carcinoma (HCC)...
To correlate the appearance of hepatocellular carcinoma on delayed (60 minutes) postcontrast T1-weighted gradient echo images with mode action gadobenate dimeglumine (Gd-BOPTA) and anatomic pathologic characteristics lesions.A total 34 patients varying degrees diffuse liver disease were studied. T2-weighted spin acquired before 60 minutes after intravenous administration 0.1 mmol/kg Gd-BOPTA. Qualitative quantitative evaluations performed correlated histologic findings. The evaluation,...
microRNAs (miRs) are 18-25 nucleotide non-coding RNAs that regulate gene expression in several physiological and pathological conditions. To gather more knowledge on human hepatocellular carcinoma (HCC) we generated a small RNA library the HCC cell line HA22T/VGH by cloning sequencing cDNA obtained following size selection of 18-24 RNAs. We determined levels most frequently cloned qPCR tissues their peritumoral counterparts from biopsy specimens 41 patients. The miRs were miR-24, miR-27a...
It has been previously demonstrated that T lymphocytes may be involved in the development of hypertension and microvascular remodeling, circulating effector increased hypertension. In particular, Th1 Th 17 contribute to progression damage while T-regulatory (Treg) seem protective this regard. However, no data is available about patients with severe obesity, which pronounced alterations were observed.We have investigated 32 severely obese undergoing bariatric surgery, as well 24 normotensive...