Francesco Puccetti
A5070559876- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Enhanced Recovery After Surgery
- Metastasis and carcinoma case studies
- Colorectal Cancer Screening and Detection
- Electrolyte and hormonal disorders
- Renal function and acid-base balance
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Dysphagia Assessment and Management
- Immunotherapy and Immune Responses
- Tracheal and airway disorders
- Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Syncope and Autonomic Disorders
- COVID-19 and healthcare impacts
- Pancreatic and Hepatic Oncology Research
- Eicosanoids and Hypertension Pharmacology
- Hormonal Regulation and Hypertension
Vita-Salute San Raffaele University
2018-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2020-2025
IRCCS Ospedale San Raffaele
2017-2024
University of L'Aquila
2024
University of Tübingen
2024
Agostino Gemelli University Polyclinic
2023
Università Cattolica del Sacro Cuore
2023
San Raffaele University of Rome
2023
Virginia Mason Medical Center
2021-2022
Delays in screening programs and the reluctance of patients to seek medical attention because outbreak SARS-CoV-2 could be associated with risk more advanced colorectal cancers at diagnosis.To evaluate whether pandemic was oncologic stage change clinical presentation for cancer.This retrospective, multicenter cohort study included all 17 938 adult who underwent surgery cancer from March 1, 2020, December 31, 2021 (pandemic period), January 2018, February 29, 2020 (prepandemic 81...
Extending the interval between end of neoadjuvant chemoradiotherapy (CRT) and surgery may enhance tumor response in patients with locally advanced rectal cancer. However, data on association delaying long-term outcome who had a minor or poor are lacking.To assess large series no to CRT shorter longer waiting times short- outcomes.This is multicenter retrospective cohort study. Data from 1701 consecutive cancer treated 12 Italian referral centers were analyzed for colorectal January 2000...
Abstract Background This study compared patients undergoing colorectal cancer surgery in 20 hospitals of northern Italy 2019 versus 2020, order to evaluate whether COVID-19-related delays screening resulted more advanced cancers at diagnosis and worse clinical outcomes. Method was a retrospective multicentre cohort analysis March December 2020. Independent predictors disease stage (oncological stage, associated symptoms, T4 metastasis) outcome (surgical complications, palliative surgery,...
Achalasia is a neurodegenerative motility disorder of the esophagus; dysphagia, weight loss, chest pain, and regurgitation are its main symptoms. Surgical myotomy (HM) considered gold standard treatment. However, peroral endoscopic (POEM) seems to be safe effective alternative option. The aim this study compare safety efficacy these techniques. From March 2012 June 2015, 74 patients with symptomatic primary achalasia underwent myotomy. two groups were compared in terms intraoperative...
Current treatment for patients with locally advanced esophageal adenocarcinoma (EAC) is neoadjuvant chemotherapy (nCT), alone or combined radiotherapy, before surgery. However, fewer than 30% of treated show a pathologic complete response to nCT, which correlates increased 5-year survival compared nonresponders. Understanding the mechanisms nCT pivotal better stratify and inform more efficacious therapies. Here, we investigated immune involved in by multidimensional profiling pretreatment...
Abstract Medical decisions driving the clinical management of octogenarians who require either major or urgent surgery still depend on patient's age rather than individual functions. This report created privileged opportunity to illustrate effectiveness a comprehensive function‐based assessment. was case an 83‐year‐old gentleman presenting with severe malnutrition and debility due esophageal cancer. Multidimensional assessments were systematically performed design best‐tailored therapeutic...
Inadvertent intraoperative hypothermia is a common occurrence during major surgery, and some preclinical studies have reported its association with postoperative anastomotic leakage (AL). In the present study, we demonstrated correlation between outcomes after Ivor Lewis (IL) esophagectomy for cancer. Retrospectively, patients were divided into three groups on basis of their time-weighted average temperatures (TWA): normothermia (N-TWA 36-37.5 °C), mild (M-TWA 35-36 severe (S-TWA < 35 °C)....
To assess whether perioperative variables or deviation from enhanced recovery after surgery (ERAS) items could be associated with delayed discharge esophagectomy, and to convert them into a scoring system predict it.ERAS pathways have been recently applied esophageal resections. However, low adherence ERAS high rates of protocol deviations are often reported.All patients who underwent esophagectomy between April 2012 March 2017 were managed standardized pathway according principles. The...
The aim of the present study is to assess effectiveness indocyanine-green (ICG)-guided lymphography (ICG-Lg) in reducing incidence chyle leak (CL) after esophagectomy.
Abstract Background The association between volume, complications and pathological outcomes is still under debate regarding colorectal cancer surgery. aim of the study was to assess centre volume severe complications, mortality, less-than-radical oncologic surgery, indications for neoadjuvant therapy. Methods Retrospective analysis 16,883 cases from 80 centres (2018–2021). Outcomes: 30-day mortality; Clavien-Dindo grade &gt;2 complications; removal ≥ 12 lymph nodes; non-radical...
Summary This study seeks to define long-term variation in body composition patients undergoing esophagectomy for cancer and associate those changes with survival. Assessment of skeletal muscle, visceral (VAT) subcutaneous adipose tissue (SAT) was performed using computed tomography (CT) images routinely acquired: at diagnosis; after neoadjuvant therapy, and; &gt;6 months esophagectomy. In cases where multiple CT scans were surgery, all available assessed. Ninty-seven met inclusion...
Abstract Background Current evidence concerning bowel preparation before elective colorectal surgery is still controversial. This study aimed to compare the incidence of anastomotic leakage (AL), surgical site infections (SSIs), and overall morbidity (any adverse event, OM) after using four different types preparation. Methods A prospective database gathered among 78 Italian centers in two studies, including 6241 patients who underwent resection with anastomosis for malignant or benign...
Esophageal cancer surgery has historically been associated with high levels of postoperative morbidity and mortality. Post-esophagectomy diaphragmatic hernia (PEDH) represents a potentially life-threatening surgical complication, incidence risk factors not clearly demonstrated. This study evaluates presenting characteristics repair outcomes in PEDH after Ivor Lewis esophagectomy for cancer.All consecutive patients who underwent esophageal between March 1997 April 2018 at two high-volume...