A5090187022- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Surgical Treatments
- Delphi Technique in Research
- Medical Imaging Techniques and Applications
- Intraperitoneal and Appendiceal Malignancies
- Cancer survivorship and care
- Diversity and Career in Medicine
- Surgical Simulation and Training
- Advanced Radiotherapy Techniques
- Enhanced Recovery After Surgery
- Clinical practice guidelines implementation
- Global Health Workforce Issues
- Stoma care and complications
- Radiopharmaceutical Chemistry and Applications
- COVID-19 and healthcare impacts
- Global Health and Surgery
- Intestinal and Peritoneal Adhesions
- Lung Cancer Treatments and Mutations
- Effects of Radiation Exposure
- Advanced Optical Imaging Technologies
- Diagnosis and Treatment of Venous Diseases
Ghent University Hospital
2015-2024
Radboud University Medical Center
2022
Leiden University Medical Center
2022
Radboud University Nijmegen
2022
Creative Research Enterprises (United States)
2019
Ghent University
2019
University of Turin
2019
Onze Lieve Vrouwziekenhuis Hospital
2010
OBJECTIVESOesophageal carcinoma (EC) remains an aggressive disease. Despite extensive changes in therapeutic modalities, surgical resection the first choice therapy for curable oesophageal cancer patients. Anastomotic sites are prone to serious complications such as leakage, fistula, bleeding and stricture. Leakage of anastomosis (AL) one main causes postoperative morbidity mortality. The purpose this study was identify predictors associated with leakage after Ivor Lewis oesophagectomy its...
Background: Esophagectomy is a technically challenging procedure, associated with significant morbidity. The introduction of minimally invasive esophagectomy (MIE) has reduced postoperative Objective: Although the short-term effect on complications increasingly being recognized, impact long-term survival remains unclear. This study aims to investigate association between following MIE and survival. Methods: Data were collected from EsoBenchmark Collaborative composed by 13 high-volume,...
Background: Surgical resection, for the most part after neoadjuvant therapy, remains primary curative option esophageal cancer, yet cancer recurrence poses a significant challenge to patient outcomes. Previous literature has shown that various anesthetic drugs could potentially influence oncological outcomes surgical resection of malignant tumors. This retrospective cohort study investigates patient-controlled epidural analgesia (PCEA) compared intravenous (PCIA) on following minimally...
Cancer patients treated with radiotherapy (RT) could develop severe late side effects that affect their quality of life. Long-term bowel complications after RT are mainly characterized by a transmural fibrosis lead to intestinal obstruction. Today, surgical resection is the only effective treatment. However, preoperative increases risk anastomotic leakage. In this study, we attempted use mesenchymal stromal cells from adipose tissue (Ad-MSCs) improve colonic anastomosis high-dose...
Little is known on functional outcome after Ivor Lewis esophagectomy (ILE) with intrathoracic anastomosis.Patients who underwent ILE were identified from a prospective database. Clinicopathological data retrieved and compared based patient self-assessment by standard questionnaire. Predictive factors for selected complaints logistic regression analyses.Three hundred twenty-two patients (80.4% male, mean age 62 years) studied. Indications surgery adenocarcinoma (62.4%), squamous cell...
Approximately 10–12% of patients with oesophageal or gastric cancer (OGC) present oligometastatic disease at diagnosis. It remains unclear if there is a role for radical surgery in these patients. We aimed to assess the outcomes OGC who underwent simultaneous treatment primary tumour and synchronous liver metastases. Patients surgical between 2008 2020 up five metastases aiming complete removal ablation (i.e., no residual tumour) were identified from four institutional databases. The outcome...
Anastomotic leak (AL) is a severe complication after esophagectomy. Clinical presentation of AL diverse and there large practice variation regarding treatment AL. This study aimed to explore different strategies their underlying rationale. mixed-methods consisted an international survey among upper gastro-intestinal (GI) surgeons focus groups with expert GI surgeons. The included 10 case vignettes data sources were integrated separate analysis. was completed by 188 respondents (completion...
Anastomotic leakage (AL) remains the main cause of post-esophagectomy morbidity and mortality. Early detection can avoid sepsis reduce This study evaluates diagnostic accuracy Nun score its components as early detectors AL. single-center observational cohort included all esophagectomies from 2010 to 2020. C-reactive protein (CRP), albumin (Alb), white cell count (WCC) were analyzed NUn scores calculated. The area under curve statistic (AUC) was used assess their predictive accuracy. A total...
Esophageal cancer (EC) remains an aggressive disease with a poor survival. Management of metastatic EC is limited to palliative chemotherapy (CT). Scientific contributions regarding the role surgery are scarce and controversial. We analysed outcome surgically treated patients.We retrospectively identified patients from our esophagectomy database. The aim this study was evaluate surgical complications, pathological response, oncological mean survival these aggressively stage IV...
SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. This is a cross-sectional study reported in compliance with CHERRIES guidelines conducted through an online platform from June 14th July 15th, 2020. The primary outcome was burden burnout during indicated by validated Shirom-Melamed Burnout Measure. Nine hundred fifty-four completed survey. median length practice 10...
Purpose: To explore whether a higher neoadjuvant radiation dose increases the probability of pathological complete response (pCR) or major (pMR) in oesophageal cancer patients.Material and methods: Between 2000 2017, 1048 patients from four institutions were stratified according to prescribed doses 36.0 Gy (13.3%), 40.0 (7.4%), 41.4 (20.1%), 45.0 (25.5%) 50.4 (33.7%) 1.8–2.0 fractions. Endpoints pCR (tumour regression grade (TRG) 1) pMR (TRG 1 + 2). Multivariable binary 2 vs. TRG > 2)...
Introduction: The main cause of anastomotic leakage (AL) is tissue hypoxia, which results from impaired perfusion the pedicle stomach graft after esophageal reconstruction. Clinical judgment unreliable in determining perfusion. Therefore, an objective, validated, and reproducible method urgently needed. Near infrared fluorescence imaging using indocyanine green (ICG) emerging promising modality. This study's objectives are to evaluate feasibility quantification ICG angiography (ICGA) assess...
Summary Background: In recent years, minimally invasive Ivor Lewis (IL) esophagectomy with high intrathoracic anastomosis has emerged as surgical standard of care for esophageal cancer in expert centers. Alongside this process, many divergent technical aspects procedure have been devised different This study aims at achieving international consensus on the steps IL reconstruction using Delphi methodology. Methods: The panel consisted specialized surgeons from 8 European countries. During a...
Anastomotic Leakage (AL) remains the main cause of post-esophagectomy morbidity and mortality. Early detection can avoid sepsis reduce This study evaluates diagnostic accuracy NUn-score its components as early detectors AL. single centre observational cohort included all esophagectomies from 2010-2020. C-reactive Protein (CRP), Albumin (Alb) White cell count (WCC) were analyzed Nun-scores calculated. Area under curves (AUC) used to assess their predictive accuracy. Seventy-four 668 patients...