A5072283957- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Lung Cancer Treatments and Mutations
- Gastroesophageal reflux and treatments
- Pancreatic and Hepatic Oncology Research
- Tracheal and airway disorders
- Colorectal Cancer Surgical Treatments
- Eosinophilic Esophagitis
- Cancer-related gene regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal and Anal Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Helicobacter pylori-related gastroenterology studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Bariatric Surgery and Outcomes
- Peptidase Inhibition and Analysis
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Dysphagia Assessment and Management
University of Cologne
2010-2024
Elisabeth-Krankenhaus Essen
2020-2024
St. Elisabethen-Krankenhaus Frankfurt
2022
Klinikum rechts der Isar
1989-2020
University Hospital Cologne
2010-2020
Agaplesion Markus Hospital
2018-2019
Klinik und Poliklinik für Psychosomatik und Psychotherapie
2001-2015
Centrum für Integrierte Onkologie
2010-2014
Weatherford College
2013
Technical University of Munich
1988-2008
Background and study aims: The application of endoscopic mucosectomy in early esophageal cancer is limited by the presence lymph-node metastasis. aim this prospective was to analyze rate involvement relative depth mucosal or submucosal tumor penetration, comparing squamous-cell carcinomas adenocarcinomas. Patients methods: A total 60 patients with pT1 - 24 (SCCs) 36 adenocarcinomas were treated transthoracic en-bloc esophagectomy two-field lymphadenectomy (n = 50) transhiatal resection 10)....
To evaluate 5-year survival of patients with locally advanced esophageal cancer (LAEC) who have undergone multimodality treatment complete histopathologic response.Patients LAEC may obtain excellent local-regional response to therapy. The overall benefit a response, when no viable tumor is present in the surgical specimen, incompletely understood and existing data are limited single-center studies relatively few patients. aim this multicenter study was define outcome after therapy for...
Abstract Background and Objectives New potential prognostic indicators aside from the TNM classification have been proposed. The aim of this study was to analyze relevance tumor length as well number involved regional lymph nodes (LNM) in patients with esophageal carcinoma. Methods Two hundred thirteen carcinoma (116 squamous cell‐ 97 adenocarcinoma) were included study. Treatment choice subtotal en bloc esophagectomy including “2‐field” lymphadenectomy. median examined (LNs) 28. Eighty...
The purpose of this study was to evaluate the frequency lymph node metastasis according depth tumor infiltration mucosa and submucosa.Currently some endoscopists extend indication for endoscopic mucosal resection in gastric cancer submucosa. However, decision between mucosectomy or gastrectomy with lymphadenectomy early depends especially on probability metastasis.One hundred twenty-six patients either had subtotal (n = 29) total 97) T1 cancer. median number resected nodes 21 (1-63). In...
Controversies exist about the management of esophageal perforation in order to eliminate septic focus. The aim this study was assess etiology, management, and outcome over a 12-year period, characterize optimal treatment options severe disease. Between May 1996 2008, 44 patients (30 men, 14 women; median age 67 years) with were treated our department. Etiology, diagnostic procedures, time interval between clinical presentation treatment, therapeutic analyzed retro- or prospectively for each...
Esophageal perforations and postoperative leakage of esophagogastrostomy are considered to be life-threatening conditions due the development mediastinitis consecutive sepsis. Vacuum-assisted closure (VAC), a well-established treatment method for superficial infected wounds, is based on negative pressure applied wound via vacuum-sealed sponge. Endoluminal VAC (E-VAC) therapy novel method, experience with its esophageal application limited.This retrospective study summarizes center high...
To identify differences in survival of patients with pT1 esophageal cancer relating to depth wall infiltration.Histologic analysis mucosal and submucosal infiltration thirds has shown an increasing rate lymph node metastases (LNM) according the cancer.One hundred seventy-one had transthoracic en bloc (n = 161) or transhiatal esophagectomy 10) for [121 adenocarcinomas (AC), 50 squamous cell carcinomas (SCC)]. The histologic specimen comprised penetration carcinoma pT1a mucosa (m1, m2, m3)...
The aim of this study was to describe anastomotic techniques used for total minimally invasive transthoracic esophagectomy (ttMIE) and analyze the associated morbidity.ttMIE faces increasing application in surgical treatment esophageal cancer. For esophagogastric reconstruction, different are currently used, but their effect on postoperative leakage morbidity has not been investigated.Patients were selected from a basic dataset, collected during 5-year period 13 international high-volume...
Background. The purpose of this study was to compare the prognosis patients with T1 squamous cell carcinoma (SCC) those Tl adenocarcinoma esophagus and explain prognostic differences by an analysis clinicopathologic characteristics. Methods. Seventy-seven early esophageal cancer who underwent esophagectomy lymphadenectomy from 1982 1993 were included in study. Clinical histopathologic characteristics, patterns lymph node metastasis, results surgery, long term 47 SCC compared 30...
The results of surgical treatment in 41 patients with early adenocarcinoma the oesophagus were analysed retrospectively.The choice was transhiatal radical subtotal oesophagectomy (n = 38); three mid or upper thoracic portion oesophagus, right transthoracic en bloc performed.One patient died within 30 days and another 90 (4.8 per cent). All tumours resected completely. Multicentricity Barrett's detected six cases high-grade dysplasia 28. Some 31 had infiltration submucosa, whereas ten,...
The indication for surgical resection of colorectal liver metastases should be guided by technical feasibility and expected prognostic benefit. aim the present study was to analyse frequency significance lymph node involvement hepatoduodenal ligament in metastases.A series 126 prospectively documented patients who underwent hepatectomy carcinoma analysed. factors with complete (R0) were studied multivariate analysis.R0 achieved 94 per cent. 30-day mortality rate 2 In all patients, nodes...
Abstract Background The outcome after oesophagectomy depends not only on the surgical procedure itself but can be improved by selection of patients based a preoperative risk score. Methods In order to compare for different histological subtypes oesophageal carcinoma, 221 with squamous cell carcinoma (SCC) and 104 an adenocarcinoma (AC) were enrolled in prospective study. assessment included socioeconomic status, alcohol tobacco consumption, general nutritional pulmonary, cardiovascular,...
In Brief Objective: To evaluate the potential of [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) after completion neoadjuvant chemoradiation for assessment histopathologic response and prognosis in multimodality treatment patients with esophageal cancer. Background: Combined without surgery are widely accepted options locally advanced Evidence suggests that to have no additional benefit from compared definitive chemoradiation. However, there is still a great lack noninvasive...
Objectives Detection rates of gastric cancer in 18F-fluorodeoxyglucose (FDG)-PET depend on the histopathological characteristics primary tumor. To clarify this observation, FDG uptake carcinoma was analyzed by focusing histopathology and expression glucose transporter (GLUT-1) Methods Thirty-five patients with diagnosis underwent FDG-PET visual image analysis measurement maximum standardized value (SUVmax) before surgical treatment. Resected tumor samples were categorized according to Union...
Background: Esophagectomy is a technically challenging procedure, associated with significant morbidity. The introduction of minimally invasive esophagectomy (MIE) has reduced postoperative Objective: Although the short-term effect on complications increasingly being recognized, impact long-term survival remains unclear. This study aims to investigate association between following MIE and survival. Methods: Data were collected from EsoBenchmark Collaborative composed by 13 high-volume,...
Utilizing a standardized dataset based on newly developed list of 27 univocally defined complications, this study analyzed data to assess the incidence and grading complications evaluate outcomes associated with gastrectomy for cancer in Europe.The absence system recording gastrectomy-associated makes it difficult compare results from different hospitals countries.Using secure online platform (www.gastrodata.org), referral centers gastric 11 European countries belonging Gastrectomy...
Transhiatal esophagectomy (THE), mostly performed in patients with adenocarcinoma of the esophagus, bears risk damage to mediastinal structures because physician's vision is poor during esophageal dissection. The authors report a new endoscopic technique, which enables microsurgical dissection esophagus under visual control, that can be simultaneously abdominal approach. clinical results unselected malignant disease were compared those undergoing conventional THE.Thirty (24 men and 6 women;...