A5000315784- Bariatric Surgery and Outcomes
- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- COVID-19 and healthcare impacts
- Esophageal and GI Pathology
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Body Contouring and Surgery
- Adrenal and Paraganglionic Tumors
- Cardiac, Anesthesia and Surgical Outcomes
- Head and Neck Anomalies
- Adrenal Hormones and Disorders
- Gastroesophageal reflux and treatments
- COVID-19 Clinical Research Studies
- Trauma and Emergency Care Studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Endometrial and Cervical Cancer Treatments
- Parathyroid Disorders and Treatments
- Intestinal and Peritoneal Adhesions
- Obesity and Health Practices
- Long-Term Effects of COVID-19
- Renal and Vascular Pathologies
- Adipose Tissue and Metabolism
- Thyroid Disorders and Treatments
Policlinico S.Orsola-Malpighi
2020-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Azienda USL di Bologna
2021-2024
University of Bologna
2019-2024
Winterthur Museum Garden and Library
2023
University of Birmingham
2020-2022
Institut de Virologie
2020-2021
AstraZeneca (Brazil)
2020
Stryker (United Kingdom)
2020
Pfizer (United Kingdom)
2020
The endogenous cannabinoid system participates in the regulation of energy balance, and its dysregulation may be implicated pathogenesis obesity. Adipose tissue endocannabinoids produce metabolic endocrine effects, but very few data are available human adipose primary fat cells.We measured expression type 1 2 receptors (CNR), enzymes cannabinoids synthesis degradation omental, sc abdominal, gluteal from lean obese subjects. Furthermore, we assessed effect CNR1 stimulation on glucose uptake...
Adrenal vein sampling is crucial for identifying the primary aldosteronism subtypes, but cutoff values ascertaining selectivity of catheterization and lateralization aldosterone secretion remain controversial.To investigate safety adrenal sampling, indexes, effect adrenocorticotropic hormone stimulation on index performance.We assessed proportion selective at different in 151 consecutive patients with undergoing bilaterally simultaneous sampling. Aldosterone-producing adenoma was diagnosed...
Specific comorbidities and old age create a greater vulnerability to severe Coronavirus Disease 19 (COVID-19). While obesity seems aggravate the course of disease, actual impact BMI cutoff which increases illness severity are still under investigation. The aim study was analyze whether represented risk factor for respiratory failure, admission intensive care unit (ICU) death.
Delays in screening programs and the reluctance of patients to seek medical attention because outbreak SARS-CoV-2 could be associated with risk more advanced colorectal cancers at diagnosis.To evaluate whether pandemic was oncologic stage change clinical presentation for cancer.This retrospective, multicenter cohort study included all 17 938 adult who underwent surgery cancer from March 1, 2020, December 31, 2021 (pandemic period), January 2018, February 29, 2020 (prepandemic 81...
The clinical and histopathological records of 149 consecutive patients with papillary thyroid microcarcinoma (PTMC), homogeneously studied operated on by the same surgeon in period 1990 to 2001, were reviewed. After a mean 6.5-year follow-up, three cases loco-regional recurrence (2%) observed. These had all undergone partial thyroidectomy only tumour relapse occurred residual tissue. No was observed treated total I. At variance other reported series, no lymph node our particular group 23...
Abstract Background This study compared patients undergoing colorectal cancer surgery in 20 hospitals of northern Italy 2019 versus 2020, order to evaluate whether COVID-19-related delays screening resulted more advanced cancers at diagnosis and worse clinical outcomes. Method was a retrospective multicentre cohort analysis March December 2020. Independent predictors disease stage (oncological stage, associated symptoms, T4 metastasis) outcome (surgical complications, palliative surgery,...
To evaluate the expression of 11beta-hydrxysteroid dehydrogenase type 1 (11beta-HSD1) in omental adipose tissue patients with Cushing's syndrome and simple obesity, compared normal weight controls.We have performed a case-control study studied from total 24 subjects (eight obese subjects, ten due to adrenal adenoma, six controls). Body mass index, blood pressure, plasma glucose, insulin, cortisol, urinary free cortisol post dexamethasone were measured standard methods. 11beta-HSD1 mRNA...
Aldosterone-producing adenomas (APAs) are a common cause of arterial hypertension, but the underlying molecular mechanisms unknown, although transcriptional modulation aldosterone synthase (CYP11B2) has been suggested. Aldosterone synthesis involves 2 main rate-limiting steps: cholesterol transport into mitochondria and CYP11B2 gene transcription. Evidence supports role Ca(2+)/calmodulin-dependent protein kinases (CAMKs) in regulation angiotensin II- potassium-stimulated production. CAMK-I...
Endometrial cancer is the most common gynecological tumor, with approximately 10 200 new cases in 2022 Italy.[1][1] Its incidence on rise, possibly linked to undefined factors, many attributing it increasing rates of obesity high-income countries. This not an
Expression analysis by reverse transcriptase (RT)-PCR indicates that human adipose tissue is not likely to perform de novo synthesis of steroid hormones from cholesterol because the mRNAs cytochromes P450scc and P450c17, steroidogenic-related proteins, steroidogenic acute regulatory protein factor 1, were detected. Instead, our data support an intracrine role tissue, in which adrenal dehydroepiandrosterone sulfate (DHEA-S), most abundant circulating androgen man, selectively uptaken,...
We set up a modified technetium-99m (Tc-99m) pertechnetate/Tc-99m MIBI (Tc-MIBI) subtraction scintigraphy for parathyroid imaging by introducing the use of potassium perchlorate (KCLO4). Initially, effect KCLO4 on technetium thyroid wash-out was evaluated in five healthy volunteers: 40-minute dynamic studies were obtained 20 minutes after injection 150 MBq (4 mCi), both baseline conditions and oral administration 400 mg KCLO4. After an average latency time 10.5 minutes, resulted fast...
Adiponectin is an adipocyte-derived circulating peptide that plays important role in adipose tissue metabolism, insulin sensitivity and cardiovascular disease. The adrenal gland, by secreting glucorticoid mineralocorticoid hormones, intervenes glucose metabolism regulation surrounded tissue. Hence, we investigated the hypothesis adiponectin receptor types 1 2 (adipo-R1 adipo-R2) are expressed human gland adrenocortical zona glomerulosa cell-derived aldosterone-producing adenoma (APA) We used...
Abstract Introduction As robotic surgery increases its reach, novel platforms are being released. We present the first 17 consecutive cases of alimentary tract performed with Hugo TM RAS (Medtronic). Methods patients were selected to undergo from February through April 2023. Exclusion criteria age <16 years, BMI>60, ASA IV. Results underwent ileocaecal resection for Chrons disease (2 M and 1 F) pseudo‐obstruction terminal ileum (1 M), cholecystectomy (3 5 F), subtotal gastrectomy D2...
Abstract Endometrial cancer (EC) is the most prevalent gynecological in high‐income countries. Its incidence skyrocketing due to increase risk factors such as obesity, which represents a true pandemic. This study aimed evaluate microRNA (miRNA) expression obesity‐related EC identify potential associations between this specific type and obesity. miRNA levels were analyzed 84 patients stratified based on body mass index (BMI; ≥30 or <30) nine noncancer women with The data further tested...