A5018505271- Gastrointestinal Tumor Research and Treatment
- Sarcoma Diagnosis and Treatment
- Carcinogens and Genotoxicity Assessment
- Chronic Myeloid Leukemia Treatments
- Gastric Cancer Management and Outcomes
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- DNA Repair Mechanisms
- Gastrointestinal disorders and treatments
- Chromatin Remodeling and Cancer
- Cancer Genomics and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Genetic factors in colorectal cancer
- Circular RNAs in diseases
- Genomics, phytochemicals, and oxidative stress
- Melanoma and MAPK Pathways
- Neurofibromatosis and Schwannoma Cases
- Radiation Therapy and Dosimetry
- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Effects of Radiation Exposure
- Cutaneous Melanoma Detection and Management
- Electric Motor Design and Analysis
- Cancer-related molecular mechanisms research
- Radiation Effects and Dosimetry
University of Bologna
2016-2025
Azienda USL di Bologna
2025
Policlinico S.Orsola-Malpighi
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Roche (Italy)
2015
German Cancer Research Center
2005-2010
Heidelberg University
2005-2010
Karolinska Institutet
2001-2010
Hôpital Tenon
1997
Sorbonne Université
1997
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered field. Our knowledge base relevant new technologies also been expanding. Thus, it is important to formulate on a regular basis updated monitoring autophagy different organisms. Despite numerous reviews, there continues be confusion regarding acceptable methods evaluate autophagy, especially multicellular...
Aging | doi:10.18632/aging.100693. Fabiola Olivieri, Massimiliano Bonafè, Liana Spazzafumo, Mirko Gobbi, Francesco Prattichizzo, Rina Recchioni, Fiorella Marcheselli, Lucia La Sala, Roberta Galeazzi, Maria Rita Rippo, Gianluca Fulgenzi, Sabrina Angelini, Raffaella Lazzarini, Anna Bonfigli, Francesca Brugè, Luca Tiano, Stefano Genovese, Antonio Ceriello, Massimo Boemi, Claudio Franceschi, Domenico Procopio, Roberto Testa
Imatinib has so far been the first-choice treatment in chronic myeloid leukemia with excellent results. However, only a proportion of patients achieve major molecular response – hence need to find biological predictors outcome select optimal therapeutic strategy now that more potent inhibitors are available. We investigated panel 20 polymorphisms seven genes, potentially associated pharmacogenetics imatinib, subset 189 newly diagnosed enrolled TOPS trial. The analysis included transporters...
Oxidative stress plays a major role in the pathophysiology of cardiac disorders, but experimental data on protective effects exogenous antioxidants are controversial. A promising cardioprotective strategy may be through induction endogenous and phase II enzymes by chemical inducers. Sulforaphane is an isothiocyanate derived from cruciferous vegetables, it has gained attention mainly as potential chemopreventive agent part detoxifying enzymes. Accordingly, this study was undertaken to...
The collaborative Cancer Genome Atlas (TCGA) project identified four distinct prognostic groups of endometrial carcinoma (EC) based on molecular alterations: (i) the ultramutated subtype that encompasses POLE mutated (POLE) cases; (ii) hypermutated subtype, characterized by MisMatch Repair deficiency (MMRd); (iii) copy-number high with p53 abnormal/mutated features (p53abn); (iv) low known as No Specific Molecular Profile (NSMP). Although value TCGA classification, NSMP carcinomas present a...
Quadruple wild-type (WT) gastrointestinal stromal tumor (GIST) is a genomic subgroup lacking KIT/PDGFRA/RAS pathway mutations, with an intact succinate dehydrogenase (SDH) complex. The aim of this work to perform wide comprehensive study on quadruple WT GIST improve the characterization these patients. We selected 14 clinical cases GIST, which nine showed sufficient DNA quality for whole exome sequencing (WES). NF1 alterations were identified directly by WES. Gene expression from...
Forty-four Finnish volunteers who were previously studied with regard to the repair rate of UV-specific cyclobutane pyrimidine dimers in skin genotyped for XPD polymorphisms at codons 312 (exon 10 G-->A, Asp-->Asn) and 751 23 A-->C, Lys-->Gln). The was measured 24 h two different dimers. data did not show consistent genotype-specific differences DNA rates among all subjects. combined exon AA CC genotype associated an approximately 50% depression but this borderline statistical significance....
Variation within the melanocortin receptor 1 (MC1R) gene, that influences phenotypic traits and susceptibility to melanoma, is abundant across populations. We assessed compared risk of melanoma in 2 European populations, German Spanish, by genotyping MC1R variants through direct DNA sequencing from 1,185 cases 1,582 controls. The presence any variant both populations was associated with a significantly increased (odds ratio OR = 1.67, 95% confidence interval CI 1.40-1.99). population...
Gastric cancer (GC) is the fifth most prevalent worldwide and third leading cause of global mortality. With advances omic studies, a heterogeneous GC landscape has been revealed, with significant molecular diversity. Given multifaceted nature GC, identification different patient subsets prognostic and/or predictive outcomes key aspect to allow tailoring specific treatments. Recently, involvement microbiota in gastric carcinogenesis described. To deepen this aspect, we compared composition...