A5026908211- Genomics, phytochemicals, and oxidative stress
- Biochemical Acid Research Studies
- Muscle metabolism and nutrition
- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
- Protein Hydrolysis and Bioactive Peptides
- Exercise and Physiological Responses
- Nuts composition and effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Free Radicals and Antioxidants
- Nuclear Receptors and Signaling
- Coenzyme Q10 studies and effects
- Horticultural and Viticultural Research
- Adenosine and Purinergic Signaling
- Synthesis and biological activity
- Selenium in Biological Systems
- Glutathione Transferases and Polymorphisms
- Genetics, Aging, and Longevity in Model Organisms
- Fatty Acid Research and Health
- Tea Polyphenols and Effects
- Garlic and Onion Studies
- Diet and metabolism studies
- Educational and Social Studies
- Plant Physiology and Cultivation Studies
University of Bologna
2016-2025
Polytechnic University of Turin
2024
SummaryObjectivesTo assess the impact of a personalized diet, with or without addition VSL#3 preparation, on biomarkers inflammation, nutrition, oxidative stress and intestinal microbiota in 62 healthy persons aged 65–85 years.DesignOpen label, randomized, multicenter study. Primary endpoint: High-sensitivity C-reactive protein.SettingCommunity.InterventionsEight week web-based dietary advice (RISTOMED platform) alone supplementation (2 capsules per day). The RISTOMED diet was optimized to...
The multifactorial nature of Alzheimer's disease (AD) is a reason for the lack effective drugs as well basis development "multi-target-directed ligands" (MTDLs). As cases increase in developing countries, there need new that are not only but also accessible. With this motivation, we report first sustainable MTDLs, derived from cashew nutshell liquid (CNSL), an inexpensive food waste with anti-inflammatory properties. We applied framework combination functionalized CNSL components and...
Background: There is a growing awareness that nutritional habits may influence risk of several inflammatory and immune-mediated disorders, including autoimmune diseases, through various mechanisms. The aim the present study was to investigate dietary their relationship with redox homeostasis in setting thyroid autoimmunity. Materials Methods: Two hundred subjects (173 females 27 males; median age, 37 years) were enrolled. None under any pharmacological treatment. Exclusion criteria...
Oxidative stress plays a major role in the pathophysiology of cardiac disorders, but experimental data on protective effects exogenous antioxidants are controversial. A promising cardioprotective strategy may be through induction endogenous and phase II enzymes by chemical inducers. Sulforaphane is an isothiocyanate derived from cruciferous vegetables, it has gained attention mainly as potential chemopreventive agent part detoxifying enzymes. Accordingly, this study was undertaken to...
An original analytical method has been developed for the determination of antioxidants trans-resveratrol (t-RSV) and cis-resveratrol (c-RSV) melatonin (MLT) in red white wine. The is based on HPLC coupled to fluorescence detection. Separation was obtained by using a RP column (C8, 150 mm x 4.6 id, 5 mum) mobile phase composed 79% aqueous phosphate buffer at pH 3.0 21% ACN. Fluorescence intensity monitored lambda = 386 nm while exciting 298 nm, mirtazapine used as internal standard. A careful...
Glycation, an endogenous process that leads to the production of advanced glycation end products (AGEs), plays a role in etiopathogenesis different neurodegenerative diseases, such as Alzheimer's disease (AD). Methylglyoxal is most potent precursor AGEs, and high levels methylglyoxal have been found cerebrospinal fluid AD patients. may contribute both inducing extensive protein cross-linking mediating oxidative stress. The aim this study was investigate sulforaphane, isothiocyanate...
Among health-promoting phytochemicals in whole grains, phenolic compounds have gained attention as they strong antioxidant properties and can protect against many degenerative diseases. Aim of this study was to profile grain extracts one modern five old common wheat (Triticum aestivum L.) varieties evaluate their potential antiproliferative or cytoprotective effect different cell culture systems.Wheat were characterized terms activity composition (HPLC/ESI-TOF-MS profile, polyphenol...
Sulforaphane (SF), one of the most important isothiocyanates in human diet, present cruciferous vegetables, is known to have chemopreventive activities different tissues. No data are available on its effects prevention skeletal muscle damage. In this study, we investigated potential protective SF treatment damage and oxidative stress induced by an acute bout exhaustive exercise rats. Male Wistar rats were treated with (25 mg/kg body wt ip) for 3 days before undergoing protocol a treadmill...
A reduction in IGF-I signaling has been found to increase lifespan multiple organisms despite the fact that is a trophic factor for many cell types and have protective effects against forms of damage acute settings. The longevity seen response reduced suggests there may be differences between chronic impact signaling. We examined possibility long-term stimulation with negative at cellular level using quiescent human fibroblasts. find fibroblast cells exposed 14 days viability as judged by...
This work was aimed at evaluating the cardioprotective effects of Castanea sativa Mill. (CSM) bark extract characterized in its phenolic composition by HPLC-DAD-MS analysis. The study performed using primary cultures neonatal rat cardiomyocytes to investigate antioxidant and cytoprotective CSM isolated guinea pig left right atria, papillary muscle, aorta evaluate direct effect on cholinergic adrenergic response. In cultured reduced intracellular reactive oxygen species formation improved...
The purpose of this study was the development multifunctional liposomes for nasal administration tacrine hydrochloride. Liposomes were prepared using traditional excipients (cholesterol and phosphatidylcholine), partly enriched with α-tocopherol and/or Omega3 fatty acids. This approach chosen in order to obtain at same time two positive results: an enhanced drug permeation through mucosa a concomitant neuroprotective effect. Several liposome formulations Reverse Phase Evaporation technique...