A5048080949- Blood groups and transfusion
- Blood transfusion and management
- Hemoglobinopathies and Related Disorders
- Telomeres, Telomerase, and Senescence
- Blood donation and transfusion practices
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Complement system in diseases
- Schizophrenia research and treatment
- Iron Metabolism and Disorders
- Trauma and Emergency Care Studies
- Erythrocyte Function and Pathophysiology
- Platelet Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Prenatal Screening and Diagnostics
- COVID-19 Clinical Research Studies
- Hemoglobin structure and function
- Healthcare Decision-Making and Restraints
- Endoplasmic Reticulum Stress and Disease
- Substance Abuse Treatment and Outcomes
- Autoimmune Neurological Disorders and Treatments
- Cardiac Arrest and Resuscitation
- SARS-CoV-2 and COVID-19 Research
- Injury Epidemiology and Prevention
- Neurogenesis and neuroplasticity mechanisms
Johns Hopkins Medicine
2021-2025
Johns Hopkins University
2021-2025
Johns Hopkins Hospital
2020-2024
Institute for Transfusion Medicine
2024
Centre for Chronic Disease Control
2023
University of Baltimore
2022
New York Hospital Queens
2019-2021
Weill Cornell Medicine
2019-2021
Cornell University
2018-2021
NewYork–Presbyterian Hospital
2019-2021
Aging is the main risk factor for Alzheimer's disease (AD); however, aspects of aging process that predispose brain to development AD are largely unknown. Astrocytes perform a myriad functions in central nervous system maintain homeostasis and support neuronal function. In vitro, human astrocytes highly sensitive oxidative stress trigger senescence program when faced with multiple types stress. order determine whether senescent appear vivo, tissue from aged individuals patients was examined...
<h3>Context</h3>There is a 30% higher case fatality rate from cancer in psychiatric patients even though their incidence of no greater than the general population. The reasons are unclear, but if increased mortality were due to lifestyle only, should be similarly increased. Other hypotheses include delays presentation, leading more advanced staging at diagnosis, and difficulties treatment access following diagnosis.<h3>Objective</h3>To assess why likely population develop die it.<h3>Design,...
<b>Objective</b> To measure the effectiveness of quadrivalent human papillomavirus (HPV) vaccine against cervical abnormalities four years after implementation a nationally funded vaccination programme in Queensland, Australia. <b>Design</b> Case-control analysis linked administrative health datasets. <b>Setting</b> <b>Participants</b> Women eligible for free (aged 12-26 2007) and attending their first smear test between April 2007 March 2011. High grade cases were women with histologically...
Aging is a major risk factor for many neurodegenerative disorders. A key feature of aging biology that may underlie these diseases cellular senescence. Senescent cells accumulate in tissues with age, undergo widespread changes gene expression, and typically demonstrate altered, pro-inflammatory profiles. Astrocyte senescence has been implicated disease, to better understand senescence-associated astrocytes, we investigated their transcriptome using RNA sequencing. Senescence was induced...
<h3>Background:</h3> Among patients with psychiatric disorders, there are 10 times as many preventable deaths from physical disorders suicide. We investigated whether compulsory community treatment, such treatment orders, could reduce all-cause mortality among disorders. <h3>Methods:</h3> conducted a population-based survival analysis of an inception cohort using record linking. The study period extended November 1997 to December 2008. included all community-based and inpatient services in...
Racial disproportionality has been a longstanding issue within child welfare. The continued overrepresentation of black children in the foster care system is troubling. authors this article conducted case study two counties New York State that have steadily decreased number an effort to identify what aspects their welfare practice impacted decline. employed document analysis, in-depth interviews, and focus groups with removal decision makers. Utilizing grounded theory approach content...
While preoperative anemia is associated with adverse perioperative outcomes, the benefits of treatment iron replacement versus red blood cell (RBC) transfusion remain uncertain. We used a national database to establish trends in iron-deficiency (IDA) and test hypothesis that may be superior RBC transfusion.
Blood transfusions are among the most common therapeutic procedures performed in hospitalized patients. This study evaluates contemporary national trends red blood cell (RBC), plasma, platelet, and cryoprecipitate transfusions. National Inpatient Sample, largest all-payer inpatient database representing 94% to 97% of US population, was evaluated from fourth quarter (Q4) 2015 through 2018. Quarterly for percentage hospitalizations with a transfusion procedure were separately examined each...
Firearm injury (FI) is the leading cause of death in children and adolescents United States (US). We describe epidemiology pediatric FI-associated emergency department (ED) visits hospitalizations US stratified by race ethnicity.
Abstract There is compelling evidence that the physical health of people with severe mental illness poor. Health‐promotion guidelines have been recommended as a mechanism for improving this population. However, there are significant barriers to adoption evidence‐based in practice. The purpose research was apply existing implementation theories examine capability system integrate promotion into service delivery. Data were collected within regional city Q ueensland, A ustralia. Fifty...
Prior studies have suggested that immune thrombotic thrombocytopenic purpura (iTTP) may display seasonal variation; however, methodologic limitations and sample sizes diminished the ability to perform a rigorous assessment. This 5-year retrospective study assessed epidemiology of iTTP determined whether it displays pattern. Patients with both initial relapsed (defined as disintegrin metalloprotease thrombospondin type motifs 13 activity <10%) from 24 tertiary centers in Australia, Canada,...
Abstract Background The Association for the Advancement of Blood and Biotherapies guidelines recommend use high‐titer COVID‐19 convalescent plasma (CCP) patients with SARS‐CoV‐2 at high risk disease progression, including those who are immunocompromised. We hypothesized that conventional units have comparable neutralizing antibody levels to CCP. Study Design Methods Conventional CCP were obtained from blood suppliers. Quantitatively measured antibodies assessed using MesoScale Discovery...
ABSTRACT Immune thrombotic thrombocytopenic purpura (iTTP) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and microvascular occlusion secondary to acquired ADAMTS13 deficiency. Contemporary data regarding iTTP treatment practices in the US, including use of caplacizumab, are lacking. We aimed characterize demographics therapies, medications apheresis practices, patients with US. retrospectively analyzed cases at 15 sites US that provide comprehensive care for iTTP....
Background: Stiff person syndrome spectrum disorders (SPSD) are a rare group of disabling neuroimmunological disorders. SPSD often requires immune therapies, especially in the setting inadequate response to symptomatic treatments. The safety and efficacy therapeutic plasma exchange (TPE) remains uncertain. Objectives: To describe safety, tolerability, TPE patients with SPSD. Design: A retrospective observational study. Methods: review seen at Johns Hopkins Hospital (JHH) from 1997 2021 was...