A5101704595- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood properties and coagulation
- Complement system in diseases
- CAR-T cell therapy research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Platelet Disorders and Treatments
- Hematological disorders and diagnostics
- Immune Cell Function and Interaction
- Renal Diseases and Glomerulopathies
- Byzantine Studies and History
- Blood transfusion and management
- Atrial Fibrillation Management and Outcomes
- Classical Antiquity Studies
- Neuroblastoma Research and Treatments
- Renal and Vascular Pathologies
- Knowledge Management and Sharing
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nursing Roles and Practices
- Shoulder Injury and Treatment
- Cystic Fibrosis Research Advances
- Blood groups and transfusion
- Neutropenia and Cancer Infections
- Sepsis Diagnosis and Treatment
University of British Columbia
2012-2025
Vancouver Coastal Health
2024-2025
Vancouver General Hospital
2020-2023
Northwestern University
2022
University of Utah
2022
Physician Assistant Education Association
2021
Abstract Objectives Trauma‐induced coagulopathy (TIC) can be fatal but preventable if recognised early. With emerging uses of rotational thromboelastometry (ROTEM) to guide transfusions in trauma, patient outcomes with TIC‐defined by initial ROTEM and conventional coagulation tests (CCTs) during massive haemorrhage protocol (MHP) activations were evaluated at a primary trauma centre British Columbia. Methods This retrospective observational study included adult patients requiring MHP from...
Prior studies have suggested that immune thrombotic thrombocytopenic purpura (iTTP) may display seasonal variation; however, methodologic limitations and sample sizes diminished the ability to perform a rigorous assessment. This 5-year retrospective study assessed epidemiology of iTTP determined whether it displays pattern. Patients with both initial relapsed (defined as disintegrin metalloprotease thrombospondin type motifs 13 activity <10%) from 24 tertiary centers in Australia, Canada,...
Abstract Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare complication after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adenoviral vector vaccination. In British Columbia (BC), Canada, provincial clinical care pathway was developed to guide clinicians in evaluating for VITT among patients who present with or thrombosis symptoms within 4 28 days vaccine exposure. All had enzyme-linked immunosorbent assay (ELISA) testing platelet factor (PF4) antibodies,...
Abstract Negative‐pressure wound therapy (NPWT) is commonly utilized to treat traumatic injuries sustained on the modern battlefield. However, NPWT has failed decrease incidence of deep tissue infections experienced by Wounded Warriors, despite attempts integrate common antimicrobials, like Ag+ nanoparticles, into dressing. The purpose this study was incorporate a unique antibiofilm compound (CZ‐01179) polyurethane matrix foam via lyophilized hydrogel scaffolding. Foam samples with 2.5%,...
An elderly woman presented in shock with a 1-day history of progressive abdominal pain, nausea and vomiting. She had severe lactic acidosis increased liver enzymes (aspartate transaminase 5613 units/l; alanine 3958 units/l) was treated broad-spectrum antibiotics fluid resuscitation. Imaging demonstrated portal vein thrombosis ischaemic necrosis. Her blood film showed neutrophilia left shift striking toxic changes, together spherocytosis (top left; all panels Wright–Giemsa stained, ×100...
Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy (TMA) caused by ADAMTS13 deficiency with mortality of up to 90% in the absence treatment, typically therapeutic plasma exchange (TPE). TTP presents similarly other TMAs which TPE ineffective and associated morbidity additional costs. Thus, we sought assess clinical laboratory parameters differentiating from our institution's catchment population.We reviewed 8 years data Canadian provincial apheresis center,...
Biceps tendinopathy and superior labrum anterior posterior lesions are a common source of shoulder pain disability can be effectively treated with biceps tenodesis. There variety open arthroscopic tenodesis techniques, but no one technique has demonstrated superiority. Arthroscopic techniques often disregard the extra-articular portions tendon as potential pain. Open address this concern; however, they associated wound complications, increased blood loss, nerve injury, disruptions to...
Abstract Introduction Activated partial thromboplastin time (PTT) coagulation waveforms produced by optical detection system analyzers provide additional potentially useful and routinely underutilized information for the evaluation of a patient's system. We aimed to identify features PTT waveforms, available all assays performed in our hospital laboratories, that may prove directing early investigations patients with unexplained prolonged PTT. Methods retrospectively reviewed 211 from...
A 20-year-old male presented with a 4-week history of dry cough, night sweats, weight loss, and fever. Blood tests showed normocytic anemia (hemoglobin 71 g/L) severe thrombocytopenia (platelets 17 × 109/L). His blood film demonstrated leukoerythroblastosis, occasional red cell fragments, giant cells in the feathered edge (Figure 1, panel A; Wright–Giemsa stain, original magnification ×400). Imaging revealed large anterior mediastinal mass. Bone marrow biopsy hypercellular extensive...