A5088306943- Colorectal Cancer Surgical Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Diverticular Disease and Complications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Anorectal Disease Treatments and Outcomes
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- Trauma and Emergency Care Studies
- Helicobacter pylori-related gastroenterology studies
- Nutrition and Health in Aging
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Blood disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Colorectal and Anal Carcinomas
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Blood transfusion and management
- Signaling Pathways in Disease
- Enhanced Recovery After Surgery
- Lymphatic Disorders and Treatments
Yuhuangding Hospital
2022-2025
Qingdao University
2022-2025
Vancouver Coastal Health
2023-2025
Fudan University
2017-2023
The First Affiliated Hospital, Sun Yat-sen University
2017-2023
Zhongshan Hospital
2017-2023
Sun Yat-sen University
2017-2023
University of Maryland, Baltimore
2023
Yeda Research and Development (Israel)
2023
Vancouver General Hospital
2020
Abstract: An increasing number of studies have demonstrated that circular RNAs (circRNAs) can regulate gene expression through interacting with microRNAs. In this study, we analyzed the antisense to CDR1as in colorectal cancer (CRC). had a higher CRC tissues compared adjacent, normal mucosa and was positively associated tumor size, T stage, lymph node metastasis, poor overall survival (OS). Downregulation suppressed cell proliferation invasion increased microRNA-7 (miR-7) expression....
Cancer-related mortality in patients with colorectal cancer (CRC) is predominantly caused by development of liver metastases (CLMs). How to screen the sensitive chemotherapy and targeted therapy key element improve prognosis CLMs patients. The study aims develop patient-derived organoids-based xenografted (PDOX-LM) model CRC, recapitulate clinical drug response.We transplanted human CRC primary tumor derived organoids murine spleen obtain liver. Immunohistochemistry (IHC) staining,...
Abstract The tumor-derived factors involved in the expansion and accumulation of myeloid-derived suppressor cells (MDSCs) metastatic dissemination colorectal cancer (CRC) to liver has not been studied. Immunohistochemistry was used detect sphingosine-1-phosphate receptor 1 (S1PR1) signal transducer activator transcription-3 (STAT3) human tumors. IL-6 interferon-γ were detected by enzyme-linked immunosorbent assay (ELISA). Tumor growth, invasion, migration evaluated MTT, transwell, wound...
Abstract Background The calculation of the tumor burden score (TBS) is not perfect because bilobar spread colorectal liver metastasis (CRLM) neglected. identification an ideal prognostic scoring system for CRLM remains controversial. Materials and Methods Patients who underwent curative intent resection from one medical center were enrolled in cohort 1 (787 patients) 2 (162 patients). Tumor relapse-free survival (RFS) was main outcome. A Cox regression model used to identify independent...
Abstract Objectives Trauma‐induced coagulopathy (TIC) can be fatal but preventable if recognised early. With emerging uses of rotational thromboelastometry (ROTEM) to guide transfusions in trauma, patient outcomes with TIC‐defined by initial ROTEM and conventional coagulation tests (CCTs) during massive haemorrhage protocol (MHP) activations were evaluated at a primary trauma centre British Columbia. Methods This retrospective observational study included adult patients requiring MHP from...
Leucine-rich repeat containing 25 (LRRC25) is distinguishingly expressed in different tumor types, but the relationship with immune cell infiltration gastric cancer stills unclear. We analyzed LRRC25 expression using pan-cancer data from The Cancer Genome Atlas and gene Gene Expression Omnibus. clinical significance was further evaluated tissues derived trials (no. NCT04208347). Through bioinformatics analysis of TCGA database UCSC Xena database, we found correlation between LRRC15, cancer,...
Patients with gastrointestinal surgery have a higher incidence of infection-related complications than the rest those who undergo clean cut surgery. It can lead to worse prognosis for patients. This study aimed assess association between glycemic variability (GV) and postoperative cancer A total 438 patients were included in this study. Using univariate multivariate regression analyses, risk factors determined. And nomogram prediction models constructed through machine learning. The...
Background Gastric cancer with a high level of serum alpha fetoprotein (AFP) is uncommon and has unique clinicopathological features poorer prognosis. The aim this research was to elucidate the prognostic gastric AFP. Methods sera from 1,286 patients treated at Qilu Hospital Shandong University January 2004 December 2008 were analyzed preoperatively for AFP, CEA CA19-9 levels after excluding active or chronic hepatitis, liver cirrhosis hepatocellular carcinoma as well preoperative distant...
To evaluate the causal relationship between 1,400 metabolites and colorectal gastric cancer. Mendelian randomisation study. Place Duration of Study: The Affiliated Yantai Yuhuangding Hospital Qingdao University, Yantai, China, from July to August 2024. Metabolite genome-wide association study (GWAS) data genetic Canadian Longitudinal Study on Aging (CLSA) as well expensive FinnGen project, respectively, were sourced. Suitable instrumental variables chosen based their with at a significance...
Liver metastasis is the main reason for poor prognosis of colorectal cancer, and identifying molecules involved in liver metastases cancer may provide effective therapeutic targets. Zinc-α2-glycoprotein 1(AZGP1) a candidate biomarker diagnosis cancer. However, its function molecular mechanism metastatic remains largely unknown. We previously found that up-regulated AZGP1 promotes proliferation, migration invasion cell line, here we elucidated regulating metastasis. In this article, was also...
Abstract Background Due to a limited patient sample size, substantial data on robotic rectal resection (RRR) is lacking. Here, we reported large consecutive cases from the real word assess safety and efficacy of RRR. Methods From September 2010 June 2017, total 1145 RRR procedures were performed in patients with stage I–IV disease. We conducted an analysis based information prospectively designed database evaluate surgical outcomes, urogenital function, long-term oncological outcomes....
Abstract Background This study investigated the effect on mortality of transfusing ABO‐incompatible plasma from all sources during trauma resuscitation. Methods Demographic, transfusion, and survival data were retrospectively extracted civilian patients. Patients divided by receipt any quantity blood product (incompatible group) or solely ABO‐compatible (compatible group). The primary outcome was 30‐day mortality, while other outcomes included 6‐ 24‐hour mortality. Mixed‐effects logistic...
We aimed to identify new predictive biomarkers for cetuximab in first-line treatment patients with RAS wild-type metastatic colorectal cancer (mCRC). The study included KRAS unresectable liver-limited mCRC treated chemotherapy or without cetuximab. Next-generation sequencing was done single nucleotide polymorphism according custom panel. Potential were identified and integrated into a model within training cohort. validated validation Thirty-one of 247(12.6%) harbored mutations. In cohort...
To investigate differences in clinical characteristics and mutational patterns between synchronous metachronous colorectal liver metastases (CLMs).From June 2008 to December 2014, patients with RAS wild-type CLMs treated at Zhongshan Hospital, Fudan University were included. DNA extracted from formalin-fixed paraffin-embedded tissue of primary tumors was sequenced next-generation sequencing for single-nucleotide polymorphism 96 genes according custom panel. Mutations compared correlated...
This case describes the benefits of perioperative chemo-immunotherapy for advanced gastric cancer and incomplete pyloric obstruction, supplemented with nutritional support. Early parenteral nutrition to stabilize status mitigate impact symptoms, in addition, throughout period also maintained oral support a tailored dietary plan. Above patient’s physical condition during immunotherapy. Eventually, this combination therapy plan leads partial response. On other hand, therapies that focus more...
Questions persist about the safety of switching non-group O recipients group uncrossmatched red blood cells (RBC) or low titer whole (LTOWB) to ABO-identical RBCs during their resuscitation.The database an earlier nine-center study transfusing incompatible plasma trauma patients was reanalyzed. The were divided into three groups based on 24-h RBC transfusion: (1) who received RBC/LTOWB units (control group, n = 1203), (2) only (n 646), (3) at least one unit and 562). Fixed marginal effect...
To evaluate the role of hepatic steatosis (HS) in patients with synchronous colorectal liver-limited metastases (CLLMs) undergoing conversion therapy.From March 2013 to 2017, a total 406 initially unresectable CLLMs accepted therapy multidisciplinary team (MDT). Before implementation therapy, all underwent CT scan assess presence and divided into HS group (n = 124) non-HS 282). After using propensity score matching (PSM) eliminate potential confounding bias two groups, hepatectomy rate...
Purpose To identify risk factors associated with short-term postoperative complications in patients gastrointestinal cancer and develop validate prediction models to predict the probability of complications. Methods A total 335 enrolled primary cohort this study were divided into training validation sets a chronological order. Using univariate multivariate logistic regression analyses, for determined, nomogram constructed. The performance was assessed respect receiver operator characteristic...
Immunoglobulin (Ig) usage has ongoing shortage concerns. Secondary immunodeficiencies (SIDs) account for a major proportion of Igs in Canada. We audited Ig patients with SID at three British Columbia hospitals to determine whether more stringent local guidelines are necessary.A retrospective chart review was performed who had ordered between 1 January 2018 and 31 December 2019 any indication. Cohorts were stratified into chronic new users, the Australian BloodSTAR used as benchmark time...