A5032501502- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory Biomarkers in Disease Prognosis
- Gastric Cancer Management and Outcomes
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Colorectal Cancer Screening and Detection
- Cancer-related molecular mechanisms research
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related Molecular Pathways
- Surgical Simulation and Training
- Diverticular Disease and Complications
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Anorectal Disease Treatments and Outcomes
- Autophagy in Disease and Therapy
Fudan University
2016-2025
Zhongshan Hospital
2016-2025
Sun Yat-sen University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Ningbo University
2025
Shanghai Cancer Institute
2018-2024
Shanxi Medical University
2023
Hôpital Cochin
2023
Jiangsu Agri-animal Husbandry Vocational College
2017-2021
Zero to Three
2018-2020
For stage II colon cancer, the efficacy of postoperative adjuvant chemotherapy remains controversial. It is well known that tumor-associated macrophages (TAMs) are important in tumor progression. In this study, TAMs were investigated as prognostic and predictive biomarkers for cancer after radical resection.This study enrolled two independent cohorts consecutive patients from one medical center with pathologic resections. Macrophages detected using IHC staining CD68 CD206. Infiltration...
Tumor purity is defined as the proportion of cancer cells in tumor tissue. The impact on colon (CC) prognosis, genetic profile, and microenvironment has not been thoroughly accessed.Clinical transcriptomic data from three public datasets, GSE17536/17537, GSE39582, TCGA, were retrospectively collected (n=1,248). each sample was inferred by a computational method based data. Survival-related analyses performed microarray dataset containing GSE17536/17537 GSE39582 (n=794), whereas TCGA utilized...
Aim: Colorectal cancer (CRC) is the leading cause of associated death worldwide and immune checkpoint blockade therapy only benefit a small set CRC patients. Tumor ferroptosis reflected immune-activation in our previous findings. Understanding mechanisms underlying how to bolster CD8+ T cells function through tumor microenvironment (TME) will greatly immunotherapy. Methods: Genes between cell were screened Cox, WGCNA differential expression analysis. Immunohistochemistry Immunofluorescence...
The role of mast cells (MCs) in colorectal cancer (CRC) progression was controversial. Thus, our study designed to evaluate the prognostic value MCs as well their correlation with immune microenvironment. A retrospective cohort CRC patients stages I–IV enrolled study. Consecutive (854) were divided into training set (427 patients) and validation randomly. findings further validated a GEO cohort, GSE39582 (556 patients). cell density (MCD) measured by immunohistochemical staining tryptase or...
Abstract The tumor-derived factors involved in the expansion and accumulation of myeloid-derived suppressor cells (MDSCs) metastatic dissemination colorectal cancer (CRC) to liver has not been studied. Immunohistochemistry was used detect sphingosine-1-phosphate receptor 1 (S1PR1) signal transducer activator transcription-3 (STAT3) human tumors. IL-6 interferon-γ were detected by enzyme-linked immunosorbent assay (ELISA). Tumor growth, invasion, migration evaluated MTT, transwell, wound...
In recent years, goose gout, a severe infectious disease, has affected the development of industry in China. Two different genotypes astrovirus (GAstV), named as GAstV-1 and GAstV-2, were identified. GAstV-2 viruses are known to be causative agent gout; however, not been isolated, relationship between gout is unknown. One full genome sequence, designated GAstV/CHN/TZ03/2019 (TZ03), was determined from clinical tissue samples diseased gosling using next-generation sequencing. The complete...
Siglec9 has been identified as an immune checkpoint molecule on tumor-associated macrophages (TAMs). Nevertheless, the expression profile and clinical significance of + TAMs in colon cancer (CC) are still not fully understood. Two cohorts from distinct medical centers were retrospectively enrolled. Immunohistochemistry immunofluorescence conducted to evaluate infiltration cells. Single-cell RNA sequencing flow cytometry utilized identify impact tumor environment, which was subsequently...
Homeobox C6 (HOXC6), a member of the homeobox family that encodes highly conserved transcription factors, plays vital role in various carcinomas. In this study, we used tissue microarray (TMA) consisting 462 CRC samples to demonstrate HOXC6 is more abundantly expressed colorectal cancer (CRC) tissues than adjacent normal mucosa. Clinicopathological data indicated higher expression correlated with poor overall survival and was associated primary tumor location right colon, (pT) stage 3/4 node...
Abstract E3 ligase is widely reported to exert fundamental functions in cancers. Through rigorous bioinformatic analysis concentrating ligases based on data from Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA), HERC3 was indicated be downregulated colorectal cancer (CRC) downregulation showed poor overall survival (OS) disease-free (DFS). qRT-PCR, western blotting Immunohistochemistry (IHC), analytical results were validated tissues Zhongshan hospital. Functionally,...
Ribosomal protein S15A (RPS15A), which has been identified as a highly conserved 40S ribosomal protein, is essential for cell survival and proliferation. The present study evaluated the functional role of RPS15A in colorectal cancer (CRC), our investigation found that was expressed cohort human CRC. High expression associated with older age (P=0.035), not receiving preoperative neoadjuvant treatment (P=0.048), higher primary pN stage (P=0.007) slightly more synchronous distant metastases...
Abstract Background Existing studies for ferroptosis and prognosis in colorectal cancer (CRC) were limited. In this study, we aim to investigate the prognostic role of markers patients with CRC exploration its micro‐environmental distributions. Methods Immunohistochemical staining was performed patients’ tissue microarray. Selection validation based on mRNA data from genome atlas (TCGA) database. Gene Set Enrichment Analysis (GSEA) indicate relative immune landmarks hallmarks. Ferroptosis...
Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors in Southern China, especially Guangdong area. To demonstrate a comprehensive profile loss heterozygosity (LOH) NPC, we applied large panel 382 microsatellite polymorphism markers covering all 22 autosomes 98 cases sporadic primary NPC. Of 335 informative markers, 83 loci showed high level LOH (presence equal to or more than 30% cases) and frequent were clustered chromosome 1p36 1p34, 3p14-p21, 3p24-p26, 3q25-q26 3q27,...
Background It remains unclear which patients can benefit from simultaneous resection of synchronous colorectal liver metastases (SCRLMs). This study aimed to examine the prognostic value patient- and tumor-related factors in predicting long-term outcomes undergoing SCRLMs help select a suitable therapeutic regimen proper surveillance. Methods Clinicopathological outcome data 154 consecutive SCRLM who underwent between July 2003 2013 were collected our prospectively established analyzed with...
Aims: Colorectal cancer (CRC) has high mortality and morbidity rates; however, the mechanism of CRC cells uncontrolled proliferation is unclarified, E3 ligases are widely reported to have crucial functions in cancers.HERC3 was once recognized as an important role CRC, however its effects on cell cycle blank.Methods: Correlation between HERC3 clinical characteristics analyzed.Coimmunoprecipitation, mass spectrometry analysis GST-pull down were performed identify interacting-proteins...
177 Background: Surgery is standard of care for pMMR early distal rectal cancer (RC), which can be partially exempted by totally neoadjuvant chemoradiotherapy (TNT) followed watch and wait. But long-term data showed that 1/3 patients had local growth( mostly in the wall)in two years. This study investigates efficacy safety TNT excision( LE) carcinoma (cT1-3N0M0) order to preserve organs. Methods: In this single-arm, phase 2 prospective trial, were eligible if they aged 18 years or older,...
<title>Abstract</title> Neoadjuvant radio-chemotherapy (nCRT) plus immune checkpoint inhibitors (ICIs) have emerged as an effective antitumor regimen for locally advanced rectal cancer. Yet, few biomarkers are developed to monitor the therapy response. Herein, we investigate longitudinal plasma proteome and metabolites profiling including 117 samples from 50 patients who received nCRT PDL1 blockade therapy. Notably, cholesterol metabolism is activated in disease non-response group during...
Background The beneficial influence of nursing interventions upon the mother during natural childbirth is profound, though it has, as yet, not been tangibly identified. This particularly important and clinical relevance in regulation pain levels experienced by such an life event. Aims study aims to evaluate effects intervention delivery on relief labor progression vaginal women. Methods A total 86 women from July 2023 August 2024 were included divided into two groups through a table random...
Robotic surgery for rectal cancer is widely used, but data on long-term oncological outcomes are still lacking. To compare the 3-year locoregional recurrence rates of middle and low in patients who underwent robotic vs conventional laparoscopic surgery. In this multicenter, superiority, randomized clinical trial, with or adenocarcinoma (cT1-T3, N0-N1, ycT1-T3 Nx) no distant metastasis were enrolled at 11 centers across 8 provinces China from July 2016 to December 2020. Among 1742 consecutive...
The tumor microenvironment (TME) plays a crucial role in progression and metastasis. However, the immune phenotypes of colorectal cancer (CRC) underlying escape mechanism have not been studied sufficiently. A total 1802 619 CRC samples from microarray TCGA cohorts were enrolled, respectively. ssGSEA algorithm unsupervised clustering used for TME cell infiltration speculation phenotype recognition above cohorts. 447 Zhongshan Hospital collected validation. Immunohistochemistry was performed...
Currently, no published studies have compared the clinical outcomes of medial-to-lateral approach (MA) and lateral-to-medial (LA) for open right hemicolectomy. Thus, present study aimed to assess whether one these approaches has any potential benefits over other.A retrospective was performed all patients who underwent hemicolectomy with pathologically confirmed disease met eligibility criteria between June 2008 2012. The population divided into an MA group LA by propensity scoring. We...
In this paper, we aim to explore clinical value of skeletal muscle index (SMI) and prognostic nutrition (PNI) on resected colorectal cancer liver metastasis (CRLM).Among the 539 patients, 355 were males. Baseline lower SMI was associated with smaller BMI, PNI, pre-albumin longer hospitalization days (P<0.05). Patients PNI had significantly shorter duration PFS OS can reflect postoperative treatment response. Postoperative 6-month's 12-month's indicate overall prognosis. When combined AUC ROC...