A5103021185- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA Research and Splicing
- RNA modifications and cancer
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Histone Deacetylase Inhibitors Research
- CRISPR and Genetic Engineering
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- Chemokine receptors and signaling
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Glioma Diagnosis and Treatment
- MRI in cancer diagnosis
Zhongshan Hospital
2014-2025
Fudan University
2014-2025
The First Affiliated Hospital, Sun Yat-sen University
2014-2025
Sun Yat-sen University
2014-2025
Wenzhou Medical University
2014-2022
First Affiliated Hospital of Wenzhou Medical University
2014-2022
Shanghai Clinical Research Center
2020
Purpose: Circular RNAs (circRNAs) are recently identified new noncoding and play an important role in tumorigenesis. Previous studies have indicated that hsa_circRNA_102958 is a potential diagnostic indicator gastric cancer. However, its colorectal cancer (CRC) poorly understood. Methods: qRT-PCR ISH were used to test gene expression tissues. Survival rate was analzyed by Kaplan-Meier curve. Luciferase reporter assay determine the interaction between circRNA miRNA or mRNA. Western blotting...
The molecular mechanisms underlying colorectal cancer (CRC) tumorigenesis remain incompletely understood, partially contributing to the mortality of CRC. Advances in identification novel are therefore an urgent need fill gap our knowledge CRC development. Here, we performed both vitro and vivo experiments along with silico analysis identify a new regulatory circuit that stimulated tumorigenesis. In this report, we, for first time, analyzed correlation FIH-1 level clinicopathological features...
Colorectal cancer (CRC) is the most common gastrointestinal malignancy, and 5-Fluorouracil (5-FU) principal chemotherapeutic drug used for its treatment. However, 5-FU resistance remains a significant challenge. Under stress conditions, tumor metabolic reprogramming influences resistance. Serine metabolism plasticity one of crucial pathways influencing in CRC. mechanisms by which CRC modulates serine under serine-deprived conditions remain unknown. We found that exogenous deprivation...
177 Background: Surgery is standard of care for pMMR early distal rectal cancer (RC), which can be partially exempted by totally neoadjuvant chemoradiotherapy (TNT) followed watch and wait. But long-term data showed that 1/3 patients had local growth( mostly in the wall)in two years. This study investigates efficacy safety TNT excision( LE) carcinoma (cT1-3N0M0) order to preserve organs. Methods: In this single-arm, phase 2 prospective trial, were eligible if they aged 18 years or older,...
// Le-chi Ye 1, 2 , Tao Chen 1 De-xiang Zhu Shi-xu Lv Jun-jun Qiu 3 Jianmin Xu Feng-Lai Yuan 4, * Wei Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, P.R. China Oncological The First Affiliated Hospital Wenzhou Medical Wenzhou, Gynecology, Obstetrics and Gynecology 4 Third to Nantong Nantong, These authors contributed equally this work Correspondence to: Wei, email: 13818661815@126.com Yuan, bjjq88@163.com Keywords: colorectal cancer, long non-coding RNA,...
Cetuximab is an effective antibody to treat colorectal cancer (CRC) by targeting the epidermal growth factor receptor (EGFR). However, mechanisms of acquired resistance cetuximab therapy, especially in patients without identifiable gene mutations, are not fully understood.Our study investigated role pumilio RNA-binding family member 1 (PUM1) resistance. We established cetuximab-resistant colon cell lines SW480R and Caco-2R knocked out PUM1 DEAD-box helicase 5 (DDX5) with clustered regularly...
Abstract Colorectal cancer (CRC) is a common malignant tumor in digestive tract with highly invasive and metastatic capacity. Drug sensitivity remains significant obstacle to successful chemotherapy CRC patients. The present study aimed explore genes related cetuximab (CTX) by clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9. Celigo image cytometer was used detect suitable cells optimal dosage of CTX. Inhibition rate CTX on Caco-2 evaluated cell counting kit-8 (CCK-8)...
Background: Long noncoding RNAs (lncRNAs) play essential functions in the development of several cancers, including colorectal cancer (CRC). Nevertheless, how PCAT18 regulates CRC tumorigenesis remains unclear. In this research, we aimed to investigate roles CRC. Materials and Methods: qRT-PCR Western blot were used analyze RNA protein levels. CCK8, colony formation, transwell wound healing assays utilized proliferation, migration invasion. Luciferase reporter assay was interactions....
Background: In a previous study, we showed that IFN-γ and TNF-α induce bone marrow mesenchymal stem cell (BMMSC) apoptosis absorption of tissue-engineered cartilage, but the induced regulatory T cells (iTreg) inhibit function TNF-α. this investigated effect iTreg on cartilage caused by endogenous Methods: We transfected TGF-β1 gene into BMMSCs co-cultured with CD4+ lymphocytes. Then, assessed expression markers (Foxp3, CD25 CD 39) level BMMSCs. addition, characterized chondrogenic-committed...
Abstract Purpose This study analyzed the oncologic outcomes of patients with low rectal cancer undergoing intersphincteric resection (ISR) compared those underwent APR to evaluate safety ISR. Methods enrolled 149 ISR and 166 receiving for LRC from January 2010 December 2020. The exclusion criterion included neoadjuvant therapy or other malignant tumors. Moreover, this used propensity score matching reduce possible confounding factors. Results After comparing 123 each group, comparable...