A5091749593- Pregnancy and preeclampsia studies
- Maternal Mental Health During Pregnancy and Postpartum
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Birth, Development, and Health
- Peripheral Artery Disease Management
- Genetic Syndromes and Imprinting
- Breastfeeding Practices and Influences
- Atherosclerosis and Cardiovascular Diseases
- Pregnancy and Medication Impact
- Adipokines, Inflammation, and Metabolic Diseases
- Retinal Imaging and Analysis
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Cardiovascular Disease and Adiposity
- Endometriosis Research and Treatment
- Electrolyte and hormonal disorders
- Blood Coagulation and Thrombosis Mechanisms
- Retinal and Optic Conditions
- Nutritional Studies and Diet
- Sodium Intake and Health
- Nuts composition and effects
- Milk Quality and Mastitis in Dairy Cows
- Cardiovascular and Diving-Related Complications
- Italian Fascism and Post-war Society
ASST Fatebenefratelli Sacco
2016-2022
University of Milan
2006-2022
University of Brescia
2015-2018
Clínica MEDS (Chile)
2018
Luigi Sacco Hospital
2010-2016
Genomic imprinting, resulting in parent-of-origin-dependent gene expression, is mainly achieved by DNA methylation. IGF2 and H19, belonging to the same cluster of imprinted genes regulated ICR1, DMR2 H19 promoter elements, play a major role fetal/placental growth. Using quantitative approaches, we explored epigenetic modulation IGF2/H19 during human development 60 normal 66 idiopathic IUGR (Intrauterine Growth Restriction) pregnancies, studying embryonic (cord blood) extraembryonic (placenta...
It has been previously demonstrated that T lymphocytes may be involved in the development of hypertension and microvascular remodeling, circulating effector increased hypertension. In particular, Th1 Th 17 contribute to progression damage while T-regulatory (Treg) seem protective this regard. However, no data is available about patients with severe obesity, which pronounced alterations were observed.We have investigated 32 severely obese undergoing bariatric surgery, as well 24 normotensive...
Amino acid placental delivery is reduced in human intrauterine growth–restricted (IUGR) fetuses, and the activity of amino transporters has been consistently shown to be decreased vitro studies. We hypothesized lower expression localization sodium-coupled neutral transporter 2 (SNAT2 (also known as SLC38A2)), altered levels intron-1 methylation, distribution single-nucleotide polymorphisms IUGR vs. normal pregnancies. studied 88 84 control placentas from singleton pregnancies at elective...
The evaluation of the morphological characteristics small resistance arteries in humans is challenging. gold standard method generally considered to be measurement by wire or pressure micromyography media-to-lumen ratio subcutaneous vessels obtained local biopsies. However, noninvasive techniques for retinal arterioles were recently proposed; particular, two approaches, scanning laser Doppler flowmetry (SLDF) and adaptive optics, seem provide useful information; both them an estimation...
Breastfeeding women are at risk of developing mastitis during the lactation period. Staphylococcus aureus has emerged as community-acquired pathogen responsible for virulence (methicillin resistance and Panton-Valentine leukocidin toxin producing).The aim was to compare microorganisms breast abscesses breastfeeding.This observational study conducted with a sample (N = 60) admitted our hospital between 2016 2018. Participants affected by abscess were studied cared multidisciplinary working...
Objective: Trophoblast expression of Human Leukocyte Antigene-G (HLA-G) is essential for feto-maternal immune tolerance and successful placentation. There contradicting evidence on the relationship between HLA-G polymorphisms preeclampsia (PE), intrauterine growth restriction (IUGR) pregnancy-induced hypertension (PIH). Here, we investigate association both maternal fetal 14 bp insertion/deletion polymorphism obstetrical complications.Methods: Clinical genetic data 282 women/fetuses (31...
Background SSRIs (Selective Serotonin Reuptake Inhibitors) are the most useful drugs to treat depression during pregnancy. Intrauterine exposure may increase risk of growth restriction, preterm birth and neonatal complications. However, advantages in treating seem exceed potential drug side effects respect not treated depression. undergo extensive hepatic first-pass metabolism with involvement several cytochrome P450 (CYPs) enzymes. Genetic polymorphisms influence expression activity CYPs...
An involvement of selective serotonin reuptake inhibitors (SSRIs) in increasing the risk malformations, neonatal withdrawal syndrome, has been suggested recently. Here, we aimed to investigate contribution individual pharmacogenetics SSRI on infants' outcome. We also estimated umbilical/maternal plasma concentration ratio pregnant women still therapy at time delivery.Thirty-four women, referred our hospital from January 2011 July 2015, who were given SSRIs third trimester, and related...
Objective: Selective serotonin reuptake inhibitors are commonly used for the treatment of pregnancy-related and postnatal depression. However, only a few studies have evaluated passage these drugs into human milk, often with conflicting results. Here, we sought to evaluate selective milk in first days after delivery their potential association neonatal outcomes.Study design: The was expressed both as percentage milk-to-plasma ratio drug concentrations relative infant dose (RID). were...
(1) Background: Breast abscess (BA) is a condition leading in the majority of cases to breastfeeding interruption. Abscesses are commonly treated with antibiotics, needle aspiration or incision and drainage (I&D), but there still no consensus on optimal treatment. Since well-defined clinical guidelines for management, we conducted retrospective, observational study aim assessing ultrasound (US)-guided management BA without surgery, regardless size. The secondary objective was microbiologic...
Some studies have linked the use of selective serotonin reuptake inhibitors and noradrenaline (SSRIs/SNRIs) to risk perinatal complications. This study explored relationship between pharmacokinetics pharmacogenetics, SSRIs/SNRIs tolerability effectiveness maternal newborn outcomes.Fifty-five pregnant women with Diagnostic Statistical Manual Mental Disorders, 5th Edition (DSM-5) diagnoses affective disorders, treated SSRIs/SNRIs, were recruited and, during third trimester, their blood samples...
Background: Breastfeeding has effects on health throughout the lives of mothers and babies. In 2014 in Italy, 10,976 babies were born through ART (assisted reproductive technology), accounting for 2.2% annual births. The study aims to assess how both social biological variables mode conception influence breastfeeding. Methods: This observational involves 161 pregnancies from three different modes conception: homologous vitro fertilization, ovum donation, spontaneous pregnancies. Neonatal...
Objective: It was proposed that early vascular ageing may be an important mechanism of damage in large conductance arteries. However it is not known whether aging also affect small resistance artery morphology. Design and method: For this reason, we investigated 100 patients with essential hypertension. Secondary forms hypertension were excluded according to standard clinical evaluations biochemical or instrumental assessments. In all patients, evaluation arteries morphology performed by a...
Objective: The evaluation of the morphological characteristics small resistance arteries in human beings not easy. gold standard is generally considered to be media lumen ratio subcutaneous vessels obtained by local biopsies and measured wire or pressure micromyiography. However, non-invasive techniques for retinal arterioles were recently proposed, particular two approaches seem provide interesting information: scanning laser Doppler flowmetry adaptive optics; both them an estimation wall...
Objective: The evaluation of the morphological characteristics small resistance arteries in human beings not easy. gold standard is generally considered to be media lumen ratio (M/L) subcutaneous vessels obtained by local biopsies and evaluated wire or pressure micromyiography. However, non-invasive techniques for retinal arterioles were recently proposed, particular two approaches seem provide interesting information: scanning laser Doppler flowmetry (SLDF) adaptive optics (AO); both them...
Background: It is was suggested that, in resistant hypertension, the presence of particularly pronounced microvascular alterations may contribute to explain relative lack response treatment Patients and Methods: We investigated a population 94 treated essential hypertensive patients. Secondary forms hypertension were excluded, all patients 24-hour blood pressure monitoring performed order exclude white coat effect. In patients, we evaluated small resistance arteries morphology by wire...