A5004158910- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Genetic factors in colorectal cancer
- Neuroblastoma Research and Treatments
- Breast Cancer Treatment Studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Gastrointestinal Tumor Research and Treatment
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- Esophageal Cancer Research and Treatment
- Estrogen and related hormone effects
- Eosinophilic Esophagitis
- Colorectal and Anal Carcinomas
- Immune cells in cancer
- HER2/EGFR in Cancer Research
- Liver Disease and Transplantation
- Cancer Genomics and Diagnostics
- Hepatitis C virus research
- Chromatin Remodeling and Cancer
- Radiomics and Machine Learning in Medical Imaging
Ospedale Policlinico San Martino
2016-2025
University of Genoa
2016-2025
Azienda Ospedaliera Sant'Andrea
2022
Sapienza University of Rome
2022
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2020-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2019
National Cancer Research Institute
2015
Martin University
2012
The Royal Free Hospital
2008-2012
University College London
2008-2012
Next-generation sequencing (NGS) was applied to 148 lung neuroendocrine tumours (LNETs) comprising the four World Health Organization classification categories: 53 typical carcinoid (TCs), 35 atypical (ACs), 27 large-cell carcinomas, and 33 small-cell carcinomas. A discovery screen conducted on 46 samples by use of whole-exome high-coverage targeted 418 genes. Eighty-eight recurrently mutated genes from both current literature were verified in cases screen, validated additional 102 LNETs...
Background Modulation of adaptive immunity may underscore the efficacy trans-arterial chemoembolization (TACE). We evaluated influence TACE on T-cell function by phenotypic lymphocyte characterization in samples patients undergoing surgery with (T+) or without (T-) prior-TACE treatment. Methods profiled intratumoral (IT), peritumoral (PT) and non-tumoral (NT) background tissue to evaluate regulatory CD4+/FOXP3+ (T-reg) immune-exhausted CD8+/PD-1+ T-cells across T+ (n=58) T− (n=61). performed...
Abstract Histopathological scoring of disease stage uses descriptive categories without measuring the amount fibrosis. Collagen, major component fibrous tissue, can be quantified by computer-assisted digital image analysis (DIA) using histological sections. We determined relationships between DIA, Ishak stage, and hepatic venous pressure gradient (HVPG) reflecting severity One hundred fifteen patients with hepatitis C virus (HCV) who had undergone transplantation 250 consecutive transjugular...
Abstract We describe a modified method of precipitating low- and very-low-density lipoproteins with polyethylene glycol, for quantitation high-density lipoprotein cholesterol. A 100 g/L concentration glycol 6000 in buffered (pH 10) solution is used. Under these conditions precipitation beta-lipoproteins complete. Values HDL cholesterol as measured this fully correspond to those obtained on separating the by ultracentrifugation or heparin-Mn2+, 46 mmol/L; are slightly higher than 92...
The role of chemotherapy for neuroendocrine tumours remains controversial and there is no standard regimen. We report the outcome a consecutive series chemonaive patients with metastatic or locally advanced treated combination 5-fluorouracil (500 mg m−2), cisplatin (70 m−2) streptozocin (1000 (FCiSt) administered three weekly up to six cycles. Patients were assessed radiological response, toxicity survival. In 79 assessable treatment FCiSt was associated an overall response rate 33% (38%...
Introduction: Differentiation between steatosis and non-alcoholic steatohepatitis (NASH) in fatty liver disease (NAFLD) is important as NASH progress to cirrhosis. No specific laboratory/imaging technique exists either diagnose or select patients for biopsy. Patients methods: We evaluated serum ferritin the features of metabolic syndrome with respect histological inflammation and/or fibrosis NAFLD patients. The Kleiner scoring system was used classify consecutive biopsies. One hundred eleven...
Background: Several types of neuroendocrine neoplasms (NENs) have been described in the duodenal tract, from low-grade tumors (NETs) to high-grade carcinomas (NECs). A comprehensive analysis histology, hormonal profile and prognostic parameters a sufficiently large NEN series cover all main kinds is however lacking. Methods: We collected retrospective 203 wall ampullary region NENs, six specialized endocrine pathology centers. All were characterized histopathologically histochemically, 190...
Few studies have focused on antigen preservation in formalin-fixed and paraffin-embedded (FFPE) tissue old archival material additional are required, especially considering that these samples an irreplaceable resource for scientific clinical research. The purpose of this study is to verify FFPE stored several decades. From the pathology archives, blocks were selected dating back 1960s, 1970s, 1980s, 1990s, 2000s 2010. A panel 12 antibodies was applied immunoreactivities compared. While...
Mixed adenoneuroendocrine carcinomas (MANECs) are composed of a poorly differentiated neuroendocrine carcinoma (NEC) and non-neuroendocrine (non-NEC) neoplastic epithelial component, each representing at least 30% the tumor. At present, prognostic factors for MANECs remain largely unexplored. We investigated clinical-pathologic features large multicenter series digestive system MANECs. Surgical specimens 200 MANEC candidates were centrally reviewed; diagnosis was confirmed in 160 cases....
DNA mutational profiling showed that atypical carcinoids (ACs) share alterations with large cell neuroendocrine carcinomas (LCNECs). Transcriptomic studies suggested LCNECs are composed of two subtypes, one which shares molecular anomalies SCLC. The missing piece information is the transcriptomic relationship between ACs and LCNECs, as a direct comparison lacking in literature.Transcriptomic genomic were investigated by next-generation sequencing discovery set 14 validated on 21 18 using...
Abstract Data on the pathology of COVID-19 are scarce; available studies show diffuse alveolar damage; however, there is scarce information chronologic evolution lung lesions. The primary aim study to describe chronology pathologic changes in by using a post-mortem transbronchial cryobiopsy approach. Our secondary correlate histologic findings with computed tomography patterns. SARS-CoV-2-positive patients, who died while intubated and mechanically ventilated, were enrolled. procedure was...
Portal vein embolisation (PVE) is used to increase the remnant liver volume before major resection for colorectal metastases. The rate after PVE 60-70%, mainly limited by disease progression. effect of on tumour growth has not been investigated. objective this study was compare characteristics resected metastases in patients undergoing pre-operative with those matched controls who had undergone PVE. There were 22 preoperative and 20 controls. Tumour calculated change (CT/MRI volumetric...
<b><i>Background/Aim:</i></b> The neuroendocrine tumor (NET) proliferation-based grading system (ENETS/WHO) for gastroenteropancreatic (GEP) tumors has proved reliable prognostic stratification. To date, concerns exist regarding Ki-67 heterogeneity within the and little is known on whether grade varies between primary secondary sites. As may have a significant impact clinical management, our aim was to retrospectively evaluate series of GEP NETs in order establish...
An increased risk of small bowel carcinoma [SBC] has been reported in coeliac disease [CD] and Crohn's [CrD]. We explored clinico-pathological, molecular, prognostic features CD-associated SBC [CD-SBC] CrD-associated [CrD-SBC] comparison with sporadic [spo-SBC].A total 76 patients undergoing surgical resection for non-familial [26 CD-SBC, 25 CrD-SBC, spo-SBC] were retrospectively enrolled to investigate patients' survival histological molecular including microsatellite instability [MSI]...