A5007365295- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Gastrointestinal Tumor Research and Treatment
- Eosinophilic Esophagitis
- Colorectal and Anal Carcinomas
- Immunotherapy and Immune Responses
- Metastasis and carcinoma case studies
- Nitric Oxide and Endothelin Effects
- Glycosylation and Glycoproteins Research
- Microscopic Colitis
- Angiogenesis and VEGF in Cancer
- Antioxidant Activity and Oxidative Stress
- Monoclonal and Polyclonal Antibodies Research
- Colorectal Cancer Surgical Treatments
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Prostate Cancer Treatment and Research
- Birth, Development, and Health
- Spondyloarthritis Studies and Treatments
- Pregnancy and preeclampsia studies
- Lipoproteins and Cardiovascular Health
University of Naples Federico II
2010-2021
University of Campania "Luigi Vanvitelli"
2013-2019
Federico II University Hospital
1998-2018
Istituti di Ricovero e Cura a Carattere Scientifico
2013
Istituto Pasteur
2013
Sapienza University of Rome
2013
University of Salerno
2013
National Cancer Institute
2013
Anthrologica
2011
Mayo Clinic
2002-2005
To determine whether oxidized LDL enhances atherogenesis by promoting monocyte recruitment into the vascular intima, we investigated accumulation and oxidation precede intimal of monocytes in human fetal aortas (from spontaneous abortions premature newborns who died within 12 h; age 6.2+/-1.3 mo). For this purpose, a systematic assessment fatty streak formation was carried out from normocholesterolemic mothers (n = 22), hypercholesterolemic 33), were only during pregnancy 27). Fetal plasma...
Maternal hypercholesterolemia during pregnancy is associated with enhanced fatty streak formation in human fetuses and faster progression of atherosclerosis childhood even under normocholesterolemic conditions. A causal role maternal lesion fetal development has previously been established rabbits. The same experimental model now used to establish that or ensuing pathogenic events arteries enhance atherogenesis later life. Five groups rabbit mothers were fed chow, cholesterol-enriched chow...
Atherosclerotic lesions in intracranial arteries occur later and are less extensive than extracranial arteries. To investigate potential mechanisms responsible for this difference, particular the atherogenic response to hypercholesterolemia LDL oxidation, we compared extent of fatty streak formation composition these very early human fetuses from normocholesterolemic hypercholesterolemic mothers with those arteries.Lesions were quantified by computer-assisted image analysis 30 oil red...
Atherosclerosis is enhanced in arterial segments exposed to disturbed flow. Perturbed shear stress increases the expression of oxidation-sensitive responsive genes (such as ELK-1 and p -JUN) endothelium. Evidence suggests that polyphenolic antioxidants contained juice derived from pomegranate can contribute reduction oxidative atherogenesis. The aim present study was evaluate effects intervention with (PJ) on endothelial NO synthase (eNOS) induced by high vitro vivo . Cultured human coronary...
Thirty two consecutive patients (age range 6 months-13.4 years) with severe reflux oesophagitis were randomised to a therapeutic trial for eight weeks during which they received either standard doses of omeprazole (40 mg/day/1.73 m2 surface area) or high ranitidine (20 mg/kg/day). Twenty five completed the (12 on omeprazole, 13 ranitidine). At entry and at end underwent symptomatic score assessment, endoscopic histological evaluation oesophagus, simultaneous oesophageal gastric pH...
In the central nervous system glial-derived S100B protein has been associated with inflammation via nitric oxide (NO) production. As role of enteroglial cells in inflammatory bowel disease poorly investigated humans, we evaluated association and NO production ulcerative colitis (UC). mRNA expression, inducible synthase (iNOS) were rectal biopsies from 30 controls 35 UC patients. To verify correlation between production, exposed to S100B, presence or absence specific receptor for advanced...
The aim of this study was to compare the accuracy and clinical impact hybrid positron emission tomography [PET]/magnetic resonance-enterography [MR-E] PET/computed tomography-enterography [CT-E] in patients with Crohn's disease [CD]. A total 35 symptomatic small-bowel CD who were scheduled undergo operation evaluated before by same-day PET/CT-E PET/MR-E. PET/MR-E also compared MR-E alone. Imaging for detecting pathological sites discriminating between fibrotic inflammatory strictures...
Although increasingly strong evidence suggests a role of maternal total cholesterol and low-density lipoprotein (LDLC) levels during pregnancy as risk factor for atherosclerotic disease in the offspring, underlying mechanisms need to be clarified future clinical applications.To test whether epigenetic signatures characterize early fetal atherogenesis associated with hypercholesterolemia provide quantitative estimate contribution level lesion size.This autopsy study analyzed 78 human aorta...
An increased risk of small bowel carcinoma [SBC] has been reported in coeliac disease [CD] and Crohn's [CrD]. We explored clinico-pathological, molecular, prognostic features CD-associated SBC [CD-SBC] CrD-associated [CrD-SBC] comparison with sporadic [spo-SBC].A total 76 patients undergoing surgical resection for non-familial [26 CD-SBC, 25 CrD-SBC, spo-SBC] were retrospectively enrolled to investigate patients' survival histological molecular including microsatellite instability [MSI]...
Helicobacter pylori, the main cause of chronic gastritis, is a class I gastric carcinogen. Chronic gastritis progresses to cancer through atrophy, metaplasia, and dysplasia. Precancerous phenotypic expression generally associated with acquired genomic instability.To evaluate effect H pylori infection its eradication on histology, cell proliferation, DNA status, oncogene expression.Morphometric immunohistochemical techniques were used examine mucosal biopsy specimens from eight controls, 10...
Background: Atherosclerosis is enhanced in arterial segments exposed to disturbed flow. Perturbed shear stress increases the expression of oxidation-sensitive responsive genes (such as ELK-1 and p-CREB). Polyphenolic antioxidants contained juice derived from pomegranate contribute reduction oxidative atherogenesis during stress. Aim study: To evaluate effects intervention with Pomegranate Fruit Extract (PFE) rich polyphones (punicalagin, which a potent antioxidant) on ELK-1, p-CREB,...
Abstract Purpose: Immunostimulating Toll-like receptor 9 (TLR9) agonists cause antitumor activity interfering also with cancer proliferation and angiogenesis by mechanisms still incompletely understood. We hypothesized that modified TLR9 could impair epidermal growth factor (EGFR) signaling and, this means, greatly enhance EGFR inhibitors effect, acting on both the targeting immunologic arm. Experimental Design: used a novel second-generation, modified, immunomodulatory agonist (IMO), alone...
Emerging evidence suggests that tumors contain and are driven by a cellular component displays stem cell properties, the so-called cancer cells (CSCs). CSCs have been identified in several solid human cancers; however, there no data about primary gastric (GC). By using CD133 CD44 surface markers we investigated whether GCs subset expressing stem-like properties this subpopulation has tumor-initiating xenograft transplantation experiments. We examined tissues from 44 patients who underwent...
Non-familial small bowel carcinomas are relatively rare and have a poor prognosis. Two carcinoma subsets may arise in distinct immune-inflammatory diseases (celiac disease Crohn's disease) been recently suggested to differ prognosis, celiac disease-associated cases showing better outcome, possibly due their higher DNA microsatellite instability tumor-infiltrating T lymphocytes. In this study, we investigated the histological structure (glandular vs diffuse/poorly cohesive, mixed or solid),...
Restenosis after percutaneous transluminal coronary angioplasty is caused by neointimal hyperplasia, which involves impairment of nitric oxide (NO)-dependent pathways, and may be further exacerbated a concomitant aging process. We compared the effects NO-releasing-aspirin (NCX-4016) aspirin (ASA) on experimental restenosis in both adult elderly rats. Moreover, to ascertain efficacy NCX-4016 during vascular aging, we fully characterized release bioactive NO drug. Sprague–Dawley rats aged 6 24...