A5039050542- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Prostate Cancer Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Cancer Cells and Metastasis
- Prostate Cancer Treatment and Research
- Gastrointestinal Tumor Research and Treatment
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Organ Transplantation Techniques and Outcomes
- Lipoproteins and Cardiovascular Health
- Intraperitoneal and Appendiceal Malignancies
- Cervical Cancer and HPV Research
- Radiomics and Machine Learning in Medical Imaging
- Digestive system and related health
- Ovarian cancer diagnosis and treatment
- Pancreatic and Hepatic Oncology Research
- HIV Research and Treatment
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- MRI in cancer diagnosis
- Urologic and reproductive health conditions
- Neuroendocrine Tumor Research Advances
- Cancer, Hypoxia, and Metabolism
- Endometriosis Research and Treatment
Sapienza University of Rome
2013-2024
Policlinico Umberto I
2012-2024
Weatherford College
2019-2020
Gleason (United States)
2020
Pathological Society
2017
Association for Symbolic Logic
2016
META Group
2016
Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Frascati
2006
Ospedale San Carlo
2002
Istituto di Fisiologia Clinica
1997-2000
Small, noncoding RNAs are short untranslated RNA molecules, some of which have been associated with cancer development. Recently we showed that a class small generated during the maturation process tRNAs (tRNA-derived RNAs, hereafter "tsRNAs") is dysregulated in cancer. Specifically, uncovered tsRNA signatures chronic lymphocytic leukemia and lung demonstrated ts-4521/3676 cluster (now called "ts-101" "ts-53," respectively), ts-46, ts-47 down-regulated these malignancies. Furthermore, tsRNAs...
Because of scarce data from larger series and nonhomogeneous selection criteria, further information is needed on peritonectomy with hyperthermic intraperitoneal chemotherapy (HIPEC) in managing patients ovarian peritoneal carcinomatosis.In an open, prospective, single-center nonrandomized phase 2 study conducted November 2000 to April 2007, 47 primary advanced or recurrent cancer diffuse carcinomatosis were enrolled; 22 underwent 25 secondary cytoreduction plus immediate HIPEC followed by...
MicroRNAs are being exploited for diagnosis, prognosis and monitoring of cancer other diseases. Their high tissue specificity critical role in oncogenesis provide new biomarkers the diagnosis classification as well predicting patients' outcomes. signatures have been identified many human tumors, including colorectal (CRC). In most cases, metastatic disease is difficult to predict prevent with adequate therapies. The aim our study was identify a microRNA signature CRC that could differentiate...
Quiescent/slow cycling cells have been identified in several tumors and correlated with therapy resistance. However, the features of chemoresistant populations molecular factors linking quiescence to chemoresistance are largely unknown.A population quiescent/slow was isolated through PKH26 staining (which allows separate on basis their proliferation rate) from colorectal cancer (CRC) xenografts subjected global gene expression pathway activation analyses. Factors expressed by were analyzed...
Circulating tumor cells (CTCs) are responsible for the metastatic dissemination of colorectal cancer (CRC) to liver, lungs and lymph nodes. CTCs rarity heterogeneity strongly limit elucidation their biological features, as well preclinical drug sensitivity studies aimed at metastasis prevention.
Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally, in human colorectal cancer (CRC), are thought exert beneficial roles controlling pro-tumor chronic inflammation. The goal of our study was characterize CRC-infiltrating at multiple levels, phenotypical, molecular and functional evaluation from the site, compared non-tumoral mucosa peripheral blood CRC patients. frequency higher than blood, further significantly increased tumor. Ex vivo, those...
An increased risk of small bowel carcinoma [SBC] has been reported in coeliac disease [CD] and Crohn's [CrD]. We explored clinico-pathological, molecular, prognostic features CD-associated SBC [CD-SBC] CrD-associated [CrD-SBC] comparison with sporadic [spo-SBC].A total 76 patients undergoing surgical resection for non-familial [26 CD-SBC, 25 CrD-SBC, spo-SBC] were retrospectively enrolled to investigate patients' survival histological molecular including microsatellite instability [MSI]...
To evaluate MRI diagnostic performance in detecting clinically significant prostate cancer (csPCa) peripheral-zone PI-RADS 4 lesions, comparing those with clearly restricted diffusion (DWI-score 4), and equivocal pattern 3) positive dynamic contrast-enhanced (DCE) MRI.This observational prospective study enrolled 389 men referred to and, if (PI-RADS 3 PSA-density [PSAD] ≥ 0.15 ng/mL/mL, 5), MRI-directed biopsy. Lesions DWI-score DCE were classified as "PI-RADS 3up," instead of 4. Univariable...
Background Hypercholesterolemia is associated with endothelial dysfunction. On the basis of hypothesis that high plasma cholesterol per se may be a sufficient stimulus to upregulate adhesiveness and this phenomenon might reversible, soluble leukocyte adhesion molecules (sELAMs) were studied in patients familial hypercholesterolemia undergoing LDL apheresis. Methods Results Selective absorption by dextran sulfate columns was used treat volumes 6.5 9.2 L; after apheresis, total cholesterol,...
In 15 elderly individuals lyophilized Bifidobacterium bifidum (BB) and Lactobacillus acidophilus (LA) (Infloran®) were administered in capsules (two 4 times per day) for 28 days, while 10 controls placebo given the same posology an equal period of time. The effects this treatment on immune system both at periphery or intestinal level investigated. Results show that BB LA significantly reduced colonic inflammatory infiltration, without altering T, B Leu7+ cell percentage. At time, a...
The stage of HIV infection at which the virus enters nervous system remains poorly understood. Examination brains HIV-positive non-AIDS patients often shows lymphocytic meningitis, myelin pallor and gliosis, but no immunohistochemical (IHC) evidence virus. In this study we have examined a number from with (23) without (8) AIDS as well 5 HIV-negative controls by morphological, morphometric, IHC polymerase chain reaction (PCR) methods in an attempt to establish what can be detected brain...
Osteo-odonto-keratoprosthesis is a technique designed for patients with severe corneal opacification who would be at high risk of graft rejection should donor tissue transplantation performed. Because the isolation prosthetic implant from tissues that provides, authors are opinion it only viable option in such patients. The visual outcome and complications procedure series 85 cases presented.
Study Type – Prognosis (case series) Level of Evidence 4 What's known on the subject? and What does study add? Primary renal synovial sarcoma is a very rare neoplasm. Since 2000, when this tumour was first described, only case reports have been published in medical literature. This to describe clinical pathological features primary it found relationship between these characteristics. Median overall disease‐free survival were reported, risk relapse for patients with non‐metastatic disease at...