Costantino Leonardo

ORCID: 0000-0003-1407-0424
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About
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Research Areas
  • Bladder and Urothelial Cancer Treatments
  • Renal cell carcinoma treatment
  • Prostate Cancer Diagnosis and Treatment
  • Urinary and Genital Oncology Studies
  • Renal and Vascular Pathologies
  • Urological Disorders and Treatments
  • Prostate Cancer Treatment and Research
  • Pediatric Urology and Nephrology Studies
  • Urinary Bladder and Prostate Research
  • Renal and related cancers
  • Urologic and reproductive health conditions
  • Pelvic floor disorders treatments
  • Ureteral procedures and complications
  • Organ Donation and Transplantation
  • Genital Health and Disease
  • Radiomics and Machine Learning in Medical Imaging
  • MRI in cancer diagnosis
  • Sperm and Testicular Function
  • Testicular diseases and treatments
  • Hormonal and reproductive studies
  • Epigenetics and DNA Methylation
  • Cardiac, Anesthesia and Surgical Outcomes
  • Sexual Differentiation and Disorders
  • Multiple and Secondary Primary Cancers
  • Cancer Immunotherapy and Biomarkers

Sapienza University of Rome
2014-2024

National Cancer Institute
2009-2024

Policlinico Umberto I
2002-2024

Istituti di Ricovero e Cura a Carattere Scientifico
2023-2024

University of Campania "Luigi Vanvitelli"
2024

Rush University
2024

Azienda Ospedaliera Universitaria Integrata Verona
2024

Rush University Medical Center
2024

Istituti Fisioterapici Ospitalieri
2024

Sir Charles Gairdner Hospital
2024

Background: Current cross-sectional imaging modalities exhibit heterogenous diagnostic performances for the detection of a lymph node invasion (LNI) in bladder cancer (BCa) patients. Recently, Node-RADS score was introduced to provide standardized comprehensive evaluation LNI, based on five-item Likert scale accounting both size and configuration criteria. In current study, we hypothesized that accurately predicts LNI tested its performance. Methods: We retrospectively reviewed BCa patients...

10.3390/cancers15030580 article EN Cancers 2023-01-18

Prostate cancer (PCa) management is moving towards patient-tailored strategies. Advances in molecular and genetic profiling of tumor tissues, integrated with clinical risk assessments, provide deeper insights into disease aggressiveness. This study aims to offer a comprehensive overview the pivotal genomic tests supporting PCa treatment decisions, analyzing-through real-world data-trends their use growth literature evidence.

10.3390/clinpract14020039 article EN cc-by Clinics and Practice 2024-03-19

We evaluated the accuracy of detrusor wall thickness and intravesical prostatic protrusion, association each test to diagnose bladder obstruction in patients with lower urinary tract symptoms.We enrolled study 100 consecutive symptoms due benign hyperplasia. Baseline parameters were International Prostate Symptom Score, prostate volume, flow rate, thickness, Schaefer class, minimal urethral opening pressure resistance algorithm outlet index. A ROC curve was produced calculate AUC evaluate...

10.1016/j.juro.2010.02.019 article EN The Journal of Urology 2010-04-19

(I) To determine Vesical Imaging-Reporting and Data System (VI-RADS) score 5 accuracy in predicting locally advanced bladder cancer (BCa), so as to potentially identify those patients who could avoid the morbidity of deep transurethral resection tumour (TURBT) favour histological sampling-TUR prior radical cystectomy (RC). (II) explore predictive value VI-RADS on time-to-cystectomy (TTC) outcomes.We retrospectively reviewed patients' ineligible or refusing cisplatin-based combination...

10.1111/bju.15188 article EN BJU International 2020-07-23

To determine the clinical, pathological, and radiological features, including Vesical Imaging-Reporting Data System (VI-RADS) score, independently correlating with muscle-invasive bladder cancer (BCa), in a multicentric national setting.

10.1007/s11547-022-01513-5 article EN cc-by La radiologia medica 2022-06-28

To evaluate MRI diagnostic performance in detecting clinically significant prostate cancer (csPCa) peripheral-zone PI-RADS 4 lesions, comparing those with clearly restricted diffusion (DWI-score 4), and equivocal pattern 3) positive dynamic contrast-enhanced (DCE) MRI.This observational prospective study enrolled 389 men referred to and, if (PI-RADS 3 PSA-density [PSAD] ≥ 0.15 ng/mL/mL, 5), MRI-directed biopsy. Lesions DWI-score DCE were classified as "PI-RADS 3up," instead of 4. Univariable...

10.1007/s00330-023-09605-0 article EN cc-by European Radiology 2023-04-13

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Feb 2003The Evolution Detrusor Overactivity After Watchful Waiting, Medical Therapy and Surgery in Patients with Bladder Outlet Obstruction COSIMO de NUNZIO, GIORGIO FRANCO, ANDREA ROCCHEGIANI, FRANCESCO IORI, COSTANTINO LEONARDO, CESARE LAURENTI NUNZIOCOSIMO NUNZIO More articles by this author , FRANCOGIORGIO FRANCO ROCCHEGIANIANDREA ROCCHEGIANI IORIFRANCESCO IORI LEONARDOCOSTANTINO LEONARDO LAURENTICESARE View All Author...

10.1016/s0022-5347(05)63949-3 article EN The Journal of Urology 2003-02-01

The purpose of the study was to investigate whether micro-TESE can improve sperm retrieval rate (SRR) compared conventional single TESE biopsy on same testicle or contralateral multiple TESE, by employing a novel stepwise approach in population poor prognosis patients with non-obstructive azoospermia (NOA).Sixty-four NOA men undergoing surgical testicular for ICSI, from March 2007 April 2013, were included this study. Patients inclusion criteria a) previous unsuccessful b) unfavorable...

10.1186/s12894-016-0138-6 article EN cc-by BMC Urology 2016-05-12

Objectives To compare long‐term functional outcomes of off‐clamp or on‐clamp partial nephrectomy patients two high‐volume centers with cT1–2/N0 M0 renal tumors and baseline estimated glomerular filtration rate >60 mL/min. Methods A 3:1 propensity score‐matched analysis was used to select homogeneous cohorts versus nephrectomy. Joinpoint regression the 2–8‐year probabilities modifications in both selected cohorts. The Kaplan–Meier method assessed risk developing a stage ≥3b chronic kidney...

10.1111/iju.14079 article EN International Journal of Urology 2019-07-24

We evaluated possible factors predicting testicular cancer in patients undergoing testis sparing surgery.We retrospectively analyzed the records of all who underwent surgery for a small mass at total 5 centers. All with 1 solitary lesion 2 cm or less on preoperative ultrasound were enrolled study. Testis consisted tumor enucleation frozen section examination. Immediate radical orchiectomy was performed cases malignancy examination but otherwise testes spared. Univariate and multivariate...

10.1097/ju.0000000000000579 article EN The Journal of Urology 2019-10-03

Objective To describe the trend in surgical volume urology Italy during coronavirus disease 2019 (COVID-19) outbreak, as a result of abrupt reorganisation Italian national health system to augment care provision symptomatic patients with COVID-19. Methods A total 33 urological units physicians affiliated AGILE consortium (Italian Group for Advanced Laparo-Endoscopic Surgery; www.agilegroup.it) were surveyed. Urologists asked report amount elective procedures week-by-week, from beginning...

10.1111/bju.15149 article EN BJU International 2020-06-18
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