A5066234551- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Digestive system and related health
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Genetic factors in colorectal cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Retinoids in leukemia and cellular processes
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- Cytokine Signaling Pathways and Interactions
- Cancer-related Molecular Pathways
- Signaling Pathways in Disease
- Circular RNAs in diseases
- HER2/EGFR in Cancer Research
- Acute Myeloid Leukemia Research
Università Cattolica del Sacro Cuore
2018-2020
Molecular Oncology (United States)
2014
Istituto di Sessuologia Clinica
2009
Quiescent/slow cycling cells have been identified in several tumors and correlated with therapy resistance. However, the features of chemoresistant populations molecular factors linking quiescence to chemoresistance are largely unknown.A population quiescent/slow was isolated through PKH26 staining (which allows separate on basis their proliferation rate) from colorectal cancer (CRC) xenografts subjected global gene expression pathway activation analyses. Factors expressed by were analyzed...
MicroRNAs (miRs) are 21- to 23-nucleo-tide RNA molecules that regulate the stability or trans-lational efficiency of target messenger RNAs proteins involved in cell growth and apoptosis. miR-92 is part mir-17-92 cluster, which comprises members with an effect on proliferation. However, role unknown, its targets have not been identified. Here, we describe a mechanism through contributes Using synthetic double-strand oligonucleotide, demonstrate increases 32D myeloid proliferation...
Let-7c, an intronic microRNA (miRNA) embedded in the long non-coding gene LINC00478, can act as a tumor suppressor by targeting oncogenes. Previous studies indicated that acute promyelocytic leukemia (APL), subtype of myelogenous (AML) bearing promoting PML/RARα fusion protein, let-7c expression seems to be controlled host promoter, which canonical Retinoic Acid Responsive Elements (RAREs) are bound all transretinoic acid (ATRA)-sensitive manner. Here, transcriptional regulation was further...
<div>Abstract<p>Let-7c, an intronic microRNA (miRNA) embedded in the long non-coding gene <i>LINC00478</i>, can act as a tumor suppressor by targeting oncogenes. Previous studies indicated that acute promyelocytic leukemia (APL), subtype of myelogenous (AML) bearing promoting PML/RARα fusion protein, let-7c expression seems to be controlled host promoter, which canonical Retinoic Acid Responsive Elements (RAREs) are bound all transretinoic acid (ATRA)–sensitive...
<p>PDF file - 77KB</p>
<p>PDF file - 549KB, S1. Cartoon of the promoter region both host gene (LINC00478) and intronic let-7c with elements all primers used.</p>
<p>PDF file - 725KB, S2. Expression of the primary transcript miR-99a and miR-125b in cell lines from different solid tumors. S3. UCSC track.</p>
<p>PDF file - 549KB, S1. Cartoon of the promoter region both host gene (LINC00478) and intronic let-7c with elements all primers used.</p>
<p>PDF file - 77KB</p>
<p>PDF file - 725KB, S2. Expression of the primary transcript miR-99a and miR-125b in cell lines from different solid tumors. S3. UCSC track.</p>
<div>Abstract<p>Let-7c, an intronic microRNA (miRNA) embedded in the long non-coding gene <i>LINC00478</i>, can act as a tumor suppressor by targeting oncogenes. Previous studies indicated that acute promyelocytic leukemia (APL), subtype of myelogenous (AML) bearing promoting PML/RARα fusion protein, let-7c expression seems to be controlled host promoter, which canonical Retinoic Acid Responsive Elements (RAREs) are bound all transretinoic acid (ATRA)–sensitive...