A5102853414- Neuroendocrine Tumor Research Advances
- HIV Research and Treatment
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal Tumor Research and Treatment
- HIV/AIDS drug development and treatment
- T-cell and B-cell Immunology
- Ultrasound and Hyperthermia Applications
- Gastrointestinal disorders and treatments
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Advanced MRI Techniques and Applications
- Intraperitoneal and Appendiceal Malignancies
- Alcohol Consumption and Health Effects
- Immunodeficiency and Autoimmune Disorders
- Liver Disease and Transplantation
- Trace Elements in Health
- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
- Myasthenia Gravis and Thymoma
The Royal Free Hospital
2014-2025
University College London
2014-2025
Sparrow Hospital
2023
Michigan State University
2023
Roland Hill (United Kingdom)
2021
Royal Free London NHS Foundation Trust
2010-2021
Institute for Liver Health
2020
Monash Health
2016
Brønnøysund Register Centre
2016
Science Oxford
2016
Introduction: Differentiation between steatosis and non-alcoholic steatohepatitis (NASH) in fatty liver disease (NAFLD) is important as NASH progress to cirrhosis. No specific laboratory/imaging technique exists either diagnose or select patients for biopsy. Patients methods: We evaluated serum ferritin the features of metabolic syndrome with respect histological inflammation and/or fibrosis NAFLD patients. The Kleiner scoring system was used classify consecutive biopsies. One hundred eleven...
The aim of this study was to compare mitotic count (MC) and Ki-67 proliferation index as prognostic markers in pancreatic midgut neuroendocrine neoplasms (NENs). Two hundred eighty-five patients with metastatic NENs were recruited. Concordance between histological grade according either or MC defined by the European Neuroendocrine Tumour Society guidelines assessed significance evaluated. There a discrepancy 44 38% assignment when using NENs, respectively. In multivariate analysis, Ki-67,...
Although passive immunization with anti-HIV-1 Env IgG1 neutralizing monoclonal antibodies (nmAbs) prevented simian-human immunodeficiency virus (SHIV) infection in rhesus monkeys, IgA nmAbs have not been tested. Here, we sought to determine whether human dimeric (d)IgA1, dIgA2, and differ their ability prevent mucosal R5 SHIV acquisition monkeys.DIgA1, versions of nmAb HGN194 were applied intrarectally three monkey groups 30 min before intrarectal challenge.After a control pharmacokinetic...
Human immunodeficiency virus (HIV) infection and the progression to AIDS are characterized by depletion of CD4(+) T-cells. HIV-1 leads apoptosis uninfected bystander cells direct killing HIV-infected cells. This is mediated, in part, Tat protein, which secreted virally infected taken up We chemically synthesized two 86-residue subtype D proteins, Ug05RP Ug11LTS, from Ugandan patients who were clinically categorized as either rapid progressor or long-term survivor, with non-conservative...
Somatostatin and dopamine receptors are both G-protein-coupled receptors. receptor (SSTR) expression in neuroendocrine tumours has been well characterised, there is evidence of tumours. In this study, we examined D2R, SSTR-2 SSTR-5 using immunohistochemistry patients with tumours.Consecutive samples formalin-fixed paraffin-embedded tumour tissue were available from 56 a histologically confirmed diagnosis (NET). The study population was divided into low-grade (n = 29), intermediate-grade 18)...
Neutralizing antibodies have been shown to protect macaques against SHIV challenge. However, genetically diverse HIV-1 clades evolved, and a key question left unanswered is whether neutralizing can confer cross-clade protection in vivo. The novel human monoclonal antibody HGN194 was isolated from an individual infected with clade AG recombinant circulating form (CRF). targets epitope the third hypervariable loop (V3) of gp120 neutralizes range relatively neutralization-sensitive resistant...
Background HIV-1 clade C (HIV-C) predominates worldwide, and anti-HIV-C vaccines are urgently needed. Neutralizing antibody (nAb) responses considered important but have proved difficult to elicit. Although some current immunogens elicit antibodies that neutralize highly neutralization-sensitive (tier 1) HIV strains, most circulating HIVs exhibiting a less sensitive 2) phenotype not neutralized. Thus, both tier 1 2 viruses needed for vaccine discovery in nonhuman primate models....
Abstract Background HIV infection and progression to AIDS is characterized by the depletion of T cells, which could be due, in part, apoptosis mediated extra-cellular HIV-encoded Tat protein as a consequence binding tubulin. Microtubules are tubulin polymers that essential for cell structure division. Molecules target microtubules induce potent anti-cancer drugs. We studied effect on polymerization three variants: HxB2 Eli from patients who rapid progressors (RP) Oyi highly exposed but...
ABSTRACT Over 50% of all human immunodeficiency virus type 1 (HIV-1) infections worldwide are caused by subtype C strains, yet most research to date focuses on B, the commonly found in North America and Europe. The HIV-1 trans - a c t ing regulatory protein (Tat) is essential for regulating productive replication HIV-1. Tat secreted HIV-infected cells alters several functions uninfected bystander cells. One such function that, acting at cell membrane, B stimulates production tumor necrosis...
Small intestinal neuroendocrine tumours (SI NETs) represent 30-50% of small bowel neoplasms and often present at an advanced stage. To date, there is relatively limited literature regarding prognostic factors affecting overall survival (OS) in stage IV disease. In addition, the prevalence mesenteric fibrosis (MF) SI NETs its effect on OS have not been sufficiently explored literature.The primary aim this study was to perform a large-scale analysis institutional cohort 387 patients with...
Appendiceal neuroendocrine neoplasms (ANEN) are uncommon entities, which run mostly an indolent course. Appendicectomy alone is usually curative, except for in a selected group of patients that deemed to be at risk loco-regional metastases, whom completion right hemicolectomy (RHC) recommended. The current "Guidelines" criteria the latter have been controversial, and may result overtreatment, concerning young patient population.The aim this study evaluate prognostic value identifying more...
Patients with encapsulated colorectal liver metastases (CRLM) have a better prognosis than those without capsule. The reason for the encapsulation is unknown. Hypoxia inducible factor-1α (HIF-1α) increases tumor angiogenesis and tissue expression associated reduced survival. Our aim was to determine whether good of CRLM HIF-1α by cancer. study selected only patients who had not undergone neoadjuvant chemotherapy prior potentially curative hepatectomy CRLM. From 30 patients, serial sections...
Chemotherapy (CT) is widely used for neuroendocrine tumours (NETs), but there are no validated biomarkers to predict response. The Ki-67 proliferation index has been proposed as a means of selecting patients CT, robust data lacking. aim this study was investigate the relationship between response chemotherapy and in NET. We reviewed from 222 NET treated with CT. Tumours were graded according index: G1 ≤2%, G2 3–20% G3 >20%. Response assessed RECIST survival calculated start death. To...
Abstract Diarrhea is the commonest gastrointestinal symptom in patients with common variable immunodeficiency (CVID). Different pathologies patients’ bowel biopsies have been described and links infections demonstrated. The aim of this study was to analyze histology CVID Royal-Free-Hospital (RFH) London cohort. Ninety-five samples from 44 adult were reviewed grouped by histological patterns. Reasons for endoscopy possible causative recorded. Lymphocyte phenotyping results compared between...
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is considered to be a rare condition associated with lung tumours (NET), and its natural history poorly described. We aimed assess the prevalence clinicopathologic characteristics of DIPNECH in NET population, investigate predictors time-to-progression (TTP) overall survival (OS).We retrospectively identified patients diagnosed between April 2005 December 2020. Clinical data were collected from medical records. The...
HIV infection and the progression to AIDS are characterized by depletion of CD4(+) T cells through apoptosis uninfected bystander direct killing HIV-infected cells. This is mediated in part human immunodeficiency virus, type 1 Tat protein, which secreted virally infected taken up CD178 gene expression, critically involved cell apoptosis. The differing ability strains induce death may play a role clinical biological differences displayed strains. We chemically synthesized 86-residue truncated...
Identification of broadly cross-reactive HIV-1-neutralizing antibodies (bnAbs) may assist vaccine immunogen design. Here we report a novel human monoclonal antibody (mAb), designated m43, which co-targets the gp120 and gp41 subunits HIV-1 envelope glycoprotein (Env). M43 bound to recombinant gp140 s from various primary isolates, membrane-associated Envs on transfected cells infected cells, as well fusion intermediate structures containing N-trimer structure, but did not bind denatured CD4...